Patents by Inventor Xiaobo Nie

Xiaobo Nie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240053245
    Abstract: Aspects of the subject technology relate to systems, methods, and computer-readable media for identifying a relative permeability of a core sample through a computerized representation of a pore structure of the sample. Specifically, a computerized representation of a three-dimensional (3D) pore structure of a core sample can be accessed. A relative permeability of oil through the 3D pore structure can be determined in three dimensions. Further, a relative permeability of water through the 3D pore structure can be determined in the three dimensions. Average relative permeabilities of oil and water of the 3D pore structure can be identified based on the relative permeability of the oil in the three dimensions and the relative permeability of the water in the three dimensions.
    Type: Application
    Filed: March 22, 2023
    Publication date: February 15, 2024
    Applicant: Halliburton Energy Services, Inc.
    Inventors: Xiaobo NIE, Jonas TOELKE, Qian FANG
  • Patent number: 11746623
    Abstract: A method is provided. Cells of a digital model of a formation are classified corresponding with one or more classes based on minerals and/or pore sizes. Wettability of the formation in the digital model is calibrated based on imbibition and/or drainage curves from physical experimentation for a rock sample and the one or more classes of the cells of the digital model.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: September 5, 2023
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Santiago Gabriel Drexler, Rafael March Castaneda Neto, Xiaobo Nie, Jonas Toelke, Milena Ferreira De Siqueira Lima
  • Publication number: 20230235649
    Abstract: A method is provided. Cells of a digital model of a formation are classified corresponding with one or more classes based on minerals and/or pore sizes. Wettability of the formation in the digital model is calibrated based on imbibition and/or drainage curves from physical experimentation for a rock sample and the one or more classes of the cells of the digital model.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 27, 2023
    Applicant: HALLIBURTON ENERGY SERVICES, INC.
    Inventors: Santiago Gabriel DREXLER, Rafael March CASTANEDA NETO, Xiaobo NIE, Jonas TOELKE, Milena FERREIRA DE SIQUEIRA LIMA
  • Publication number: 20230088599
    Abstract: MicroRNA, including one of or a combination of the following components: (a) a pri-miRNA of miR-149-3p; (b) a pre-miRNA of miR-149-3p; (c) a mature miRNA of miR-149-3p; (d) a miR-149-3p derivative; (e) a 18-26 nucleotides miRNA having a sequence of 5?-AGGGAGG-3?; and (f) a derivative of the 18-26 nucleotides miRNA of (e). Also provided is a method for treating a metabolic disease. The method includes preparing a pharmaceutical composition comprising a mimic of miR-149-3p, or an expression vector of the miR-149-3p, and administering an effective amount of the pharmaceutical composition to a patient in need thereof.
    Type: Application
    Filed: August 29, 2022
    Publication date: March 23, 2023
    Inventors: Weidong CHEN, Xiaobo NIE, Yandong WANG, Yun ZHOU, Xinrui LYU
  • Patent number: 11561215
    Abstract: Overlapping pores in a multiscale model of heterogeneous core formation contributes errors during flow simulations. A scale-coupled multiscale modeling that corrects for contributions of overlapping pores may be used to determine capillary pressure and relative permeability of the heterogenous core formation more accurately. The effects of overlapping pores may be removed by converting pores that have a certain radius or are filled with certain fluids into solid regions. The effects of overlapping pores may also be removed by running flow simulations on a modified model and correcting various fluid properties of the core formation with the results.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: January 24, 2023
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Xiaobo Nie, Jonas Toelke
  • Patent number: 11249002
    Abstract: A method may comprise obtaining a formation sample, scanning the formation sample to form a data packet, loading the data packet on an information handling machine, performing a digital porous plate experiment with the data packet, and determining geometry of a pore throat in the formation sample. A system may comprise a computer tomographic machine configured to scan a formation sample and create a data packet from the scan and an information handling system. The information handling system may be configured to configured to perform a digital porous plate experiment with the data packet and determine geometry of a pore throat in the formation sample.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: February 15, 2022
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Xiaobo Nie, Jonas Toelke
  • Patent number: 11118449
    Abstract: This description relates to computer simulation of physical processes, such as computer simulation of multi-species flow through porous media including the determination/estimation of relative permeabilities for the multi-species flow through the porous media.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: September 14, 2021
    Assignee: Dassault Systemes Simulia Corp.
    Inventors: Bernd Crouse, Xiaobo Nie, Raoyang Zhang, Yong Li, Hiroshi Otomo, Hudong Chen, Andrew Fager
  • Publication number: 20210132026
    Abstract: Overlapping pores in a multiscale model of heterogeneous core formation contributes errors during flow simulations. A scale-coupled multiscale modeling that corrects for contributions of overlapping pores may be used to determine capillary pressure and relative permeability of the heterogenous core formation more accurately. The effects of overlapping pores may be removed by converting pores that have a certain radius or are filled with certain fluids into solid regions. The effects of overlapping pores may also be removed by running flow simulations on a modified model and correcting various fluid properties of the core formation with the results.
    Type: Application
    Filed: October 31, 2019
    Publication date: May 6, 2021
    Inventors: Xiaobo Nie, Jonas Toelke
  • Publication number: 20200309667
    Abstract: A method may comprise obtaining a formation sample, scanning the formation sample to form a data packet, loading the data packet on an information handling machine, performing a digital porous plate experiment with the data packet, and determining geometry of a pore throat in the formation sample. A system may comprise a computer tomographic machine configured to scan a formation sample and create a data packet from the scan and an information handling system. The information handling system may be configured to configured to perform a digital porous plate experiment with the data packet and determine geometry of a pore throat in the formation sample.
    Type: Application
    Filed: October 17, 2019
    Publication date: October 1, 2020
    Applicant: Halliburton Energy Services, Inc.
    Inventors: Xiaobo Nie, Jonas Toelke
  • Patent number: 10550690
    Abstract: This description relates to computer simulation of physical processes, such as computer simulation of multi-species flow through porous media including the determination/estimation of relative permeabilities for the multi-species flow through the porous media.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: February 4, 2020
    Assignee: Dassault Systemes Simulia Corp.
    Inventors: Bernd Crouse, Xiaobo Nie, Raoyang Zhang, Yong Li, Hiroshi Otomo, Hudong Chen, Andrew Fager, David M. Feed
  • Publication number: 20190368344
    Abstract: This description relates to computer simulation of physical processes, such as computer simulation of multi-species flow through porous media including the determination/estimation of relative permeabilities for the multi-species flow through the porous media.
    Type: Application
    Filed: July 15, 2019
    Publication date: December 5, 2019
    Inventors: Bernd Crouse, Xiaobo Nie, Raoyang Zhang, Yong Li, Hiroshi Otomo, Hudong Chen, Andrew Fager
  • Publication number: 20190153446
    Abstract: MicroRNA, including one of or a combination of the following components: (a) a pri-miRNA of miR-149-3p; (b) a pre-miRNA of miR-149-3p; (c) a mature miRNA of miR-149-3p; (d) a miR-149-3p derivative; (e) a 18-26 nucleotides miRNA having a sequence of 5?-AGGGAGG-3?; and (f) a derivative of the 18-26 nucleotides miRNA of (e). Also provided is a method for treating a metabolic disease. The method includes employing a DNA sequence encoding miR-149-3p as a target gene, constructing an overexpression vector of the miR-149-3p, preparing a pharmaceutical composition including the overexpression vector of the miR-149-3p, and administering the pharmaceutical composition to a patient in need thereof.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 23, 2019
    Inventors: Weidong CHEN, Xiaobo NIE, Yandong WANG, Yun ZHOU, Xinrui LV
  • Publication number: 20140343858
    Abstract: This description relates to computer simulation of physical processes, such as computer simulation of multi-species flow through porous media including the determination/estimation of relative permeabilities for the multi-species flow through the porous media.
    Type: Application
    Filed: May 15, 2014
    Publication date: November 20, 2014
    Applicant: Exa Corporation
    Inventors: Bernd Crouse, Xiaobo Nie, Raoyang Zhang, Yong Li, Hiroshi Otomo, Hudong Chen, Andrew Fager