Patents by Inventor Xiaochen Wei
Xiaochen Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12194099Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.Type: GrantFiled: January 20, 2023Date of Patent: January 14, 2025Assignee: Bexion Pharmaceuticals Inc.Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
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Publication number: 20230226188Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.Type: ApplicationFiled: January 20, 2023Publication date: July 20, 2023Applicant: Bexion Pharmaceuticals Inc.Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
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Publication number: 20200384112Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.Type: ApplicationFiled: May 1, 2020Publication date: December 10, 2020Applicant: Bexion Pharmaceuticals Inc.Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
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Patent number: 10682411Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.Type: GrantFiled: November 2, 2018Date of Patent: June 16, 2020Assignee: Bexion Pharmaceuticals Inc.Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
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Publication number: 20190290764Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.Type: ApplicationFiled: November 2, 2018Publication date: September 26, 2019Applicant: Bexion Pharmaceuticals Inc.Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
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Publication number: 20190231790Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 membered rinType: ApplicationFiled: April 8, 2019Publication date: August 1, 2019Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Patent number: 10251890Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: GrantFiled: September 19, 2016Date of Patent: April 9, 2019Assignee: University of KentuckyInventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Patent number: 9926263Abstract: A solvent medium for diazotization reaction includes a mixed solution of polyethylene glycol and water. The molecular weight of polyethylene glycol is 200-600, and the volume ratio of polyethylene glycol and water is 1:0.4-1.5. The mixed solution also includes hydrochloric acid or sulfuric acid, and the concentration of H+ in the mixed solution is 0.32-1.72 mol L?1.Type: GrantFiled: June 25, 2014Date of Patent: March 27, 2018Assignee: NANTONG TEXTILE & SILK INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiajie Long, Xiaochen Wei, Ming Shen
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Patent number: 9920473Abstract: A device for color-fixing processing on textiles includes a supercritical carbon dioxide fluid unit, a fixing liquid storage tank (2) and a fixing reactor (9). The fixing liquid storage tank (2) is below the fixing reactor (9) and sealed connected by a connecting device (6). The fixing liquid storage tank (2) has a cylindrical cavity in which a fluid distributor (4) is mounted. The fluid distributor (4) is composed of several interconnected pipes which bend down with the nozzles downward, and one of the pipes is used as circulated fluid inlet (1) connected with the supercritical carbon dioxide fluid unit, and the rest of the pipes are used as circulated fluid outlets.Type: GrantFiled: September 3, 2013Date of Patent: March 20, 2018Assignee: SOOCHOW UNIVERSITYInventors: Jiajie Long, Chuanglong Cui, Hongmei Xu, Xiaochen Wei, Feng Chen
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Patent number: 9739010Abstract: A phase-transfer catalytic color fixation processing method for textile includes the following steps: (1) dry-dyeing a textile with disperse reactive dyes in supercritical carbon dioxide fluid under waterless condition; (2) putting the textile in a phase-transfer catalytic fixation device, taking phase-transfer catalyst as the carrier of circulated supercritical carbon dioxide fluid, transporting the ionized fixing catalytic alkaline substance from aqueous phase to hydrophobic supercritical carbon dioxide fluid phase, getting full contact with functional groups on fibers, resulting in the fixing catalytic reaction with disperse reactive dyes.Type: GrantFiled: September 3, 2013Date of Patent: August 22, 2017Assignee: Soochow UniversityInventors: Jiajie Long, Hongmei Xu, Chuanglong Cui, Feng Chen, Xiaochen Wei
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Publication number: 20170224698Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R3, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: ApplicationFiled: September 19, 2016Publication date: August 10, 2017Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Publication number: 20170073303Abstract: A solvent medium for diazotization reaction includes a mixed solution of polyethylene glycol and water. The molecular weight of polyethylene glycol is 200-600, and the volume ratio of polyethylene glycol and water is 1:0.4-1.5. The mixed solution also includes hydrochloric acid or sulfuric acid, and the concentration of H+ in the mixed solution is 0.32-1.72 mol L?1.Type: ApplicationFiled: June 25, 2014Publication date: March 16, 2017Inventors: Jiajie LONG, Xiaochen WEI, Ming SHEN
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Patent number: 9447112Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: GrantFiled: June 1, 2015Date of Patent: September 20, 2016Assignee: University of KentuckyInventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Publication number: 20160230335Abstract: The present invention relates to a phase-transfer catalytic colour fixation processing method for a textile. The processing method comprises the following steps: dyeing a natural fibre textile in a supercritical carbon dioxide fluid waterless dyeing system using a disperse reactive dye, and then realizing a reaction fixation of the dye on the fibres using a phase transfer catalyst in the supercritical carbon dioxide fluid. Since the method utilizes the action of the phase-transfer catalyst in the colour fixation stage, an ionized colour fixation reaction accelerator and the like is effectively transferred to the supercritical carbon dioxide colour fixation fluid and solid-phase fibres, thus improving the nucleophilic reactivity of the functional group on the fibres, achieving the colour fixation reaction between the fibres and the dye in the supercritical carbon dioxide fluid conditions, and improving the colour fixation efficiency of the dye on the fibres.Type: ApplicationFiled: September 3, 2013Publication date: August 11, 2016Inventors: Jiajie LONG, Hongmei XU, Chuanglong CUI, Feng CHEN, Xiaochen WEI
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Publication number: 20160194825Abstract: A device for colour-fixing processing on textiles includes a system of supercritical carbon dioxide fluid, a fixing liquid storage tank (2) and a fixing reactor (9). The fixing liquid storage tank (2) is below the fixing reactor (9) and sealed connected by a connecting device (6). The fixing liquid storage tank (2) has a cylindrical cavity in which a fluid distributor (4) is mounted. The fluid distributor (4) is composed of several interconnected pipes which bending down with the nozzles downward, and one of the pipes is used as circulated fluid inlet (1) connected with the supercritical carbon dioxide fluid system, and the rest pipes are used as circulated fluid outlets.Type: ApplicationFiled: September 3, 2013Publication date: July 7, 2016Inventors: Jiajie LONG, Chuanglong CUI, Hongmei XU, Xiaochen WEI, Feng CHEN
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Publication number: 20150259356Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: ApplicationFiled: June 1, 2015Publication date: September 17, 2015Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Patent number: 9045490Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: GrantFiled: May 5, 2014Date of Patent: June 2, 2015Assignee: University of KentuckyInventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Publication number: 20150099731Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: ApplicationFiled: May 5, 2014Publication date: April 9, 2015Applicant: University of KentuckyInventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Patent number: 8716329Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: GrantFiled: June 24, 2013Date of Patent: May 6, 2014Assignee: University of KentuckyInventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
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Publication number: 20130288371Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 meType: ApplicationFiled: June 24, 2013Publication date: October 31, 2013Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei