Patents by Inventor Xiaochen Wei

Xiaochen Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12194099
    Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.
    Type: Grant
    Filed: January 20, 2023
    Date of Patent: January 14, 2025
    Assignee: Bexion Pharmaceuticals Inc.
    Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
  • Publication number: 20230226188
    Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 20, 2023
    Applicant: Bexion Pharmaceuticals Inc.
    Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
  • Publication number: 20200384112
    Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.
    Type: Application
    Filed: May 1, 2020
    Publication date: December 10, 2020
    Applicant: Bexion Pharmaceuticals Inc.
    Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
  • Patent number: 10682411
    Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: June 16, 2020
    Assignee: Bexion Pharmaceuticals Inc.
    Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
  • Publication number: 20190290764
    Abstract: Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.
    Type: Application
    Filed: November 2, 2018
    Publication date: September 26, 2019
    Applicant: Bexion Pharmaceuticals Inc.
    Inventors: Ellen K. Monson, Xiaochen Wei, Ray Takigiku, Charles A. Cruze, III, Joseph W. Wyse
  • Publication number: 20190231790
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 membered rin
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Patent number: 10251890
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: April 9, 2019
    Assignee: University of Kentucky
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Patent number: 9926263
    Abstract: A solvent medium for diazotization reaction includes a mixed solution of polyethylene glycol and water. The molecular weight of polyethylene glycol is 200-600, and the volume ratio of polyethylene glycol and water is 1:0.4-1.5. The mixed solution also includes hydrochloric acid or sulfuric acid, and the concentration of H+ in the mixed solution is 0.32-1.72 mol L?1.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: March 27, 2018
    Assignee: NANTONG TEXTILE & SILK INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiajie Long, Xiaochen Wei, Ming Shen
  • Patent number: 9920473
    Abstract: A device for color-fixing processing on textiles includes a supercritical carbon dioxide fluid unit, a fixing liquid storage tank (2) and a fixing reactor (9). The fixing liquid storage tank (2) is below the fixing reactor (9) and sealed connected by a connecting device (6). The fixing liquid storage tank (2) has a cylindrical cavity in which a fluid distributor (4) is mounted. The fluid distributor (4) is composed of several interconnected pipes which bend down with the nozzles downward, and one of the pipes is used as circulated fluid inlet (1) connected with the supercritical carbon dioxide fluid unit, and the rest of the pipes are used as circulated fluid outlets.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: March 20, 2018
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Jiajie Long, Chuanglong Cui, Hongmei Xu, Xiaochen Wei, Feng Chen
  • Patent number: 9739010
    Abstract: A phase-transfer catalytic color fixation processing method for textile includes the following steps: (1) dry-dyeing a textile with disperse reactive dyes in supercritical carbon dioxide fluid under waterless condition; (2) putting the textile in a phase-transfer catalytic fixation device, taking phase-transfer catalyst as the carrier of circulated supercritical carbon dioxide fluid, transporting the ionized fixing catalytic alkaline substance from aqueous phase to hydrophobic supercritical carbon dioxide fluid phase, getting full contact with functional groups on fibers, resulting in the fixing catalytic reaction with disperse reactive dyes.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: August 22, 2017
    Assignee: Soochow University
    Inventors: Jiajie Long, Hongmei Xu, Chuanglong Cui, Feng Chen, Xiaochen Wei
  • Publication number: 20170224698
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R3, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Application
    Filed: September 19, 2016
    Publication date: August 10, 2017
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Publication number: 20170073303
    Abstract: A solvent medium for diazotization reaction includes a mixed solution of polyethylene glycol and water. The molecular weight of polyethylene glycol is 200-600, and the volume ratio of polyethylene glycol and water is 1:0.4-1.5. The mixed solution also includes hydrochloric acid or sulfuric acid, and the concentration of H+ in the mixed solution is 0.32-1.72 mol L?1.
    Type: Application
    Filed: June 25, 2014
    Publication date: March 16, 2017
    Inventors: Jiajie LONG, Xiaochen WEI, Ming SHEN
  • Patent number: 9447112
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: September 20, 2016
    Assignee: University of Kentucky
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Publication number: 20160230335
    Abstract: The present invention relates to a phase-transfer catalytic colour fixation processing method for a textile. The processing method comprises the following steps: dyeing a natural fibre textile in a supercritical carbon dioxide fluid waterless dyeing system using a disperse reactive dye, and then realizing a reaction fixation of the dye on the fibres using a phase transfer catalyst in the supercritical carbon dioxide fluid. Since the method utilizes the action of the phase-transfer catalyst in the colour fixation stage, an ionized colour fixation reaction accelerator and the like is effectively transferred to the supercritical carbon dioxide colour fixation fluid and solid-phase fibres, thus improving the nucleophilic reactivity of the functional group on the fibres, achieving the colour fixation reaction between the fibres and the dye in the supercritical carbon dioxide fluid conditions, and improving the colour fixation efficiency of the dye on the fibres.
    Type: Application
    Filed: September 3, 2013
    Publication date: August 11, 2016
    Inventors: Jiajie LONG, Hongmei XU, Chuanglong CUI, Feng CHEN, Xiaochen WEI
  • Publication number: 20160194825
    Abstract: A device for colour-fixing processing on textiles includes a system of supercritical carbon dioxide fluid, a fixing liquid storage tank (2) and a fixing reactor (9). The fixing liquid storage tank (2) is below the fixing reactor (9) and sealed connected by a connecting device (6). The fixing liquid storage tank (2) has a cylindrical cavity in which a fluid distributor (4) is mounted. The fluid distributor (4) is composed of several interconnected pipes which bending down with the nozzles downward, and one of the pipes is used as circulated fluid inlet (1) connected with the supercritical carbon dioxide fluid system, and the rest pipes are used as circulated fluid outlets.
    Type: Application
    Filed: September 3, 2013
    Publication date: July 7, 2016
    Inventors: Jiajie LONG, Chuanglong CUI, Hongmei XU, Xiaochen WEI, Feng CHEN
  • Publication number: 20150259356
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Application
    Filed: June 1, 2015
    Publication date: September 17, 2015
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Patent number: 9045490
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: June 2, 2015
    Assignee: University of Kentucky
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Publication number: 20150099731
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Application
    Filed: May 5, 2014
    Publication date: April 9, 2015
    Applicant: University of Kentucky
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Patent number: 8716329
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: May 6, 2014
    Assignee: University of Kentucky
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Publication number: 20130288371
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Application
    Filed: June 24, 2013
    Publication date: October 31, 2013
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei