Patents by Inventor Xiaochen Xie

Xiaochen Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PfAgo mutant protein mesophilic target nucleic acid cleavage activity and application thereof
    Patent number: 12054757
    Abstract: A Pyrococcus furiosus Argonaute (PfAgo) mutant protein with mesophilic target nucleic acid cleavage activity and an application thereof are provided. The PfAgo mutant protein has an amino acid mutation on at least one of a 617th position and a 618th position relative to the sequence shown in SEQ ID NO: 1, specifically, K617E/G and/or L618Y/F/W/G. Compared with a wild-type PfAgo protein, the provided PfAgo mutant protein has activity in the temperature range of 30-95 Celsius degree (° C.), effectively expanding application range of prokaryotic Argonaute (pAgo) protein.
    Type: Grant
    Filed: January 27, 2024
    Date of Patent: August 6, 2024
    Assignee: HUBEI UNIVERSITY
    Inventors: Lixin Ma, Longyu Wang, Fei Wang, Xiaochen Xie, Wanping Chen, Fuyong Huang