Abstract: Disclosed is a genetically modified mouse having an immunoglobulin heavy chain locus engineered to insert a gene segment of a human immunoglobulin heavy chain variable region. The mouse is able to reproduce normally and produce a human-mouse chimeric antibody comprising a human heavy chain variable region and a mouse constant region. Also provided is a method for preparing the genetically modified mouse and use of the mouse.

Abstract: The present disclosure refers to a device and a method for the addition of liquid additives in the form of a spray during a jet milling step in a process for the manufacture of sintered NdFeB alloy magnets. The device includes: a storage barrel for the liquid additive; a weighing bucket which is in fluid communication with the storage barrel and is adapted for weighing a predetermined amount of the liquid additive; a powder container to accommodate NdFeB alloy material prior to or after jet milling, wherein the powder container includes an opening that is plugged with a blind flange; a connecting pipe, which is in fluid communication with the weighing bucket and passes through an opening of the blind flange into the interior of the powder container; and a fluid atomization nozzle located at the end of the connection pipe.

Abstract: The present disclosure refers to a device and a method for the addition of liquid additives in the form of a spray during a jet milling step in a process for the manufacture of sintered NdFeB alloy magnets. The device includes: a storage barrel for the liquid additive; a weighing bucket which is in fluid communication with the storage barrel and is adapted for weighing a predetermined amount of the liquid additive; a powder container to accommodate NdFeB alloy material prior to or after jet milling, wherein the powder container includes an opening that is plugged with a blind flange; a connecting pipe, which is in fluid communication with the weighing bucket and passes through an opening of the blind flange into the interior of the powder container; and a fluid atomization nozzle located at the end of the connection pipe.

Abstract: The disclosure provides a method for preparing a radiation-oriented sintered arc-shaped Nd—Fe—B magnet. The method comprises: providing a Nd—Fe—B powder and a molding device; performing a first sub-step of align pressing including filling the arc-shaped cavity of the molding device with a first powder loading of the Nd—Fe—B powder, performing a first magnetization of the Nd—Fe—B powder, and mold pressing the Nd—Fe—B powder to form a first green body; performing a second sub-step of align pressing including filling the arc-shaped cavity of the molding device with a second powder loading of the Nd—Fe—B powder, performing a second magnetization of the Nd—Fe—B powder, and mold pressing the Nd—Fe—B powder to form a second green body; and sintering and annealing the second green body to obtain an arc-shaped Nd—Fe—B magnet. Further aspects of the disclosure are a molding device useful for the preparation method and a radiation-oriented sintered arc-shaped Nd—Fe—B magnet obtained by the method.