Patents by Inventor Xiaochen ZHAO

Xiaochen ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260158138
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Application
    Filed: October 1, 2025
    Publication date: June 11, 2026
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Publication number: 20260141579
    Abstract: According to an embodiment of the disclosure, a method, apparatus, device and storage medium for generating an image are provided. The method includes: generating, by a motion encoder, a motion feature of a driving image; determining a transformation feature of a first object in the driving image relative to a second object in a reference image, the transformation feature indicating a position change and/or a size change; updating the motion feature based on the transformation feature; and providing the updated motion feature and an appearance feature of the reference image to a diffusion model to generate a target image, where the target image retains a motion characteristic of the first object in the driving image, and the target image retains an identity characteristic of the second object in the reference image.
    Type: Application
    Filed: November 21, 2025
    Publication date: May 21, 2026
    Inventors: Xiaochen ZHAO, Hongyi XU, Guoxian SONG, You XIE, Chenxu ZHANG, Xiu LI, Linjie LUO, Jinli SUO, Yebin LIU
  • Publication number: 20260097118
    Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.
    Type: Application
    Filed: September 29, 2025
    Publication date: April 9, 2026
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Patent number: 12582713
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Grant
    Filed: January 25, 2024
    Date of Patent: March 24, 2026
    Assignees: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano Huang, Thomas Arthur Haby, Mehrnaz Khossravi, Scott Aaron Hart, Rao Venkatramana Mantri, Heather Elizabeth Vezina, Amit Roy, Bindu Purnima Murthy, Urvi Ashish Aras, Kinjal Sanghavi, Xiaochen Zhao, Akintunde Bello
  • Publication number: 20260034212
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-LI antibody.
    Type: Application
    Filed: October 14, 2025
    Publication date: February 5, 2026
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Publication number: 20250252233
    Abstract: A neural network-based method for predicting aerodynamic performance of a compressor of modeling design and a system therefor are provided. The method includes: constructing a data set; constructing a loss function, wherein the loss function is constructed based on a similarity modeling criterion; training a momentum-optimized neural network model according to the data set and the loss function to obtain an aerodynamic performance prediction model of the compressor of modeling design; predicting an aerodynamic performance of the compressor of modeling design by using the aerodynamic performance prediction model of the compressor of modeling design. According to the method, the momentum-optimized neural network model is trained by using the constructed data set and the loss function constructed based on the similarity modeling criterion, and the deep learning technology is applied to the aerodynamic performance prediction of the compressor of modeling design.
    Type: Application
    Filed: September 10, 2024
    Publication date: August 7, 2025
    Inventors: Chen LIU, Zexi WU, Yipeng CAO, Chenqi YU, Xu ZHAN, Jie YANG, Xiaochen ZHAO
  • Publication number: 20250205334
    Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.
    Type: Application
    Filed: August 22, 2024
    Publication date: June 26, 2025
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Patent number: 12297847
    Abstract: A noise-reducing and nonuniform tip clearance structure of centrifugal compressor is provided, which includes a compressor impeller body and a compressor impeller shroud. The compressor impeller shroud is circumferentially wrapped outside the compressor impeller body, and multiple impeller blade bodies are uniformly arranged in a circumferential direction of the compressor impeller body. A clearance between an impeller tip meridian line of the impeller blade body and an impeller shroud meridian line on the compressor impeller shroud is an impeller tip clearance. The impeller tip clearance gradually decreases in a direction from a leading edge to a trailing edge of the impeller blade body, and a change rate of the impeller tip clearance in the direction from the leading edge to the trailing edge of the impeller blade body also gradually decreases.
    Type: Grant
    Filed: November 8, 2024
    Date of Patent: May 13, 2025
    Assignee: Harbin Engineering University
    Inventors: Yipeng Cao, Shaoran Du, Chen Liu, Yao Song, Jie Yang, Xiaochen Zhao, Jie Guo, Xinyu Zhang
  • Patent number: 12276242
    Abstract: Provided is an intake bypass recirculation structure capable of silencing, including: an intake bypass recirculation structure body and a structure-conducted silencing device. An intake bypass recirculation cavity is provided on the intake bypass recirculation structure body. An inlet of the intake bypass recirculation structure and an outlet of the intake bypass recirculation structure that are provided on the intake bypass recirculation structure body are each connected to the intake bypass recirculation cavity. The structure-conducted silencing device is disposed inside the intake bypass recirculation cavity. In this application, during working, noise generated by a compressor is transmitted into the intake bypass recirculation cavity via an inlet of the intake bypass recirculation structure, and transmitted outside via the outlet of the intake bypass recirculation structure.
    Type: Grant
    Filed: December 18, 2024
    Date of Patent: April 15, 2025
    Assignee: Harbin Engineering University
    Inventors: Yipeng Cao, Yao Song, Chen Liu, Xiaochen Zhao, Jiaxuan Lin, Shaoran Du, Jie Yang, Jie Guo, Xinyu Zhang
  • Publication number: 20250057948
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Application
    Filed: June 6, 2024
    Publication date: February 20, 2025
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Publication number: 20240252629
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Application
    Filed: January 25, 2024
    Publication date: August 1, 2024
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Patent number: 11946485
    Abstract: Some embodiments of the disclosure provide an air intake bypass recirculation structure with adjustable air entraining amount and controllable broadband noise which includes main body of the air intake bypass recirculation structure and an air entraining amount adjusting structure. In some examples, an air intake bypass recirculation cavity is formed in the main body of the air intake bypass recirculation structure. An air inlet of an air intake pipe and an air outlet of the air intake pipe are formed in two ends of the main body of the air intake bypass recirculation structure respectively. An airflow inlet of the air intake bypass recirculation structure and an airflow outlet of the air intake bypass recirculation structure are formed in the inner side of the main body of the air intake bypass recirculation structure. The air entraining amount adjusting structure is arranged in the air intake bypass recirculation cavity.
    Type: Grant
    Filed: August 14, 2023
    Date of Patent: April 2, 2024
    Assignee: Harbin Engineering University
    Inventors: Chen Liu, Zequn Ma, Yipeng Cao, Runze Zhang, Xinyu Zhang, Wenping Zhang, Jie Yang, Changhong Sun, Jie Guo, Xiaochen Zhao, Gongmin Liu
  • Patent number: 11905916
    Abstract: A turbocharger air intake silencer with adjustable cavity space structures is provided. The turbocharger air intake silencer comprises a silencer connecting flange and a first resonator device. The first resonator device comprises a first silencer sealing plate, a first annular sound absorption cavity body, a first rotary table, a first rotary steering gear and a first valve. A first sound absorption cavity is enclosed by the first silencer sealing plate, the first annular sound absorption cavity body, the first valve and the first rotary table. A first sound absorption cavity inlet pipe is arranged beside the first sound absorption cavity. The first sound absorption cavity and the first sound absorption cavity inlet pipe form a Helmholtz resonator. The first rotary steering gear is mounted on the silencer connecting flange. The rotary steering gear is connected with a first rotary rack.
    Type: Grant
    Filed: August 1, 2023
    Date of Patent: February 20, 2024
    Assignee: HARBIN ENGINEERING UNIVERSITY
    Inventors: Yipeng Cao, Zequn Ma, Chen Liu, Runze Zhang, Xinyu Zhang, Wenping Zhang, Zhuoyan Feng, Yuan Gao, Xiaochen Zhao, Gongmin Liu
  • Publication number: 20240052849
    Abstract: Some embodiments of the disclosure provide an air intake bypass recirculation structure with adjustable air entraining amount and controllable broadband noise which includes main body of the air intake bypass recirculation structure and an air entraining amount adjusting structure. In some examples, an air intake bypass recirculation cavity is formed in the main body of the air intake bypass recirculation structure. An air inlet of an air intake pipe and an air outlet of the air intake pipe are formed in two ends of the main body of the air intake bypass recirculation structure respectively. An airflow inlet of the air intake bypass recirculation structure and an airflow outlet of the air intake bypass recirculation structure are formed in the inner side of the main body of the air intake bypass recirculation structure. The air entraining amount adjusting structure is arranged in the air intake bypass recirculation cavity.
    Type: Application
    Filed: August 14, 2023
    Publication date: February 15, 2024
    Applicant: Harbin Engineering University
    Inventors: Chen LIU, Zequn MA, Yipeng CAO, Runze ZHANG, Xinyu ZHANG, Wenping ZHANG, Jie YANG, Changhong SUN, Jie GUO, Xiaochen ZHAO, Gongmin LIU
  • Publication number: 20240044306
    Abstract: A turbocharger air intake silencer with adjustable cavity space structures is provided. The turbocharger air intake silencer comprises a silencer connecting flange and a first resonator device. The first resonator device comprises a first silencer sealing plate, a first annular sound absorption cavity body, a first rotary table, a first rotary steering gear and a first valve. A first sound absorption cavity is enclosed by the first silencer sealing plate, the first annular sound absorption cavity body, the first valve and the first rotary table. A first sound absorption cavity inlet pipe is arranged beside the first sound absorption cavity. The first sound absorption cavity and the first sound absorption cavity inlet pipe form a Helmholtz resonator. The first rotary steering gear is mounted on the silencer connecting flange. The rotary steering gear is connected with a first rotary rack.
    Type: Application
    Filed: August 1, 2023
    Publication date: February 8, 2024
    Inventors: YIPENG CAO, ZEQUN MA, CHEN LIU, RUNZE ZHANG, XINYU ZHANG, WENPING ZHANG, ZHUOYAN FENG, YUAN GAO, XIAOCHEN ZHAO, GONGMIN LIU
  • Publication number: 20240024471
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Application
    Filed: August 21, 2023
    Publication date: January 25, 2024
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Publication number: 20240000934
    Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.
    Type: Application
    Filed: August 21, 2023
    Publication date: January 4, 2024
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Publication number: 20220233689
    Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Application
    Filed: December 27, 2021
    Publication date: July 28, 2022
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano Huang, Thomas Arthur Haby, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
  • Publication number: 20220233693
    Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.
    Type: Application
    Filed: December 27, 2021
    Publication date: July 28, 2022
    Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.
    Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO