Patents by Inventor Xiaochen ZHAO
Xiaochen ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260158138Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.Type: ApplicationFiled: October 1, 2025Publication date: June 11, 2026Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Publication number: 20260141579Abstract: According to an embodiment of the disclosure, a method, apparatus, device and storage medium for generating an image are provided. The method includes: generating, by a motion encoder, a motion feature of a driving image; determining a transformation feature of a first object in the driving image relative to a second object in a reference image, the transformation feature indicating a position change and/or a size change; updating the motion feature based on the transformation feature; and providing the updated motion feature and an appearance feature of the reference image to a diffusion model to generate a target image, where the target image retains a motion characteristic of the first object in the driving image, and the target image retains an identity characteristic of the second object in the reference image.Type: ApplicationFiled: November 21, 2025Publication date: May 21, 2026Inventors: Xiaochen ZHAO, Hongyi XU, Guoxian SONG, You XIE, Chenxu ZHANG, Xiu LI, Linjie LUO, Jinli SUO, Yebin LIU
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Publication number: 20260097118Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.Type: ApplicationFiled: September 29, 2025Publication date: April 9, 2026Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Patent number: 12582713Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.Type: GrantFiled: January 25, 2024Date of Patent: March 24, 2026Assignees: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano Huang, Thomas Arthur Haby, Mehrnaz Khossravi, Scott Aaron Hart, Rao Venkatramana Mantri, Heather Elizabeth Vezina, Amit Roy, Bindu Purnima Murthy, Urvi Ashish Aras, Kinjal Sanghavi, Xiaochen Zhao, Akintunde Bello
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Publication number: 20260034212Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-LI antibody.Type: ApplicationFiled: October 14, 2025Publication date: February 5, 2026Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Publication number: 20250252233Abstract: A neural network-based method for predicting aerodynamic performance of a compressor of modeling design and a system therefor are provided. The method includes: constructing a data set; constructing a loss function, wherein the loss function is constructed based on a similarity modeling criterion; training a momentum-optimized neural network model according to the data set and the loss function to obtain an aerodynamic performance prediction model of the compressor of modeling design; predicting an aerodynamic performance of the compressor of modeling design by using the aerodynamic performance prediction model of the compressor of modeling design. According to the method, the momentum-optimized neural network model is trained by using the constructed data set and the loss function constructed based on the similarity modeling criterion, and the deep learning technology is applied to the aerodynamic performance prediction of the compressor of modeling design.Type: ApplicationFiled: September 10, 2024Publication date: August 7, 2025Inventors: Chen LIU, Zexi WU, Yipeng CAO, Chenqi YU, Xu ZHAN, Jie YANG, Xiaochen ZHAO
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Publication number: 20250205334Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.Type: ApplicationFiled: August 22, 2024Publication date: June 26, 2025Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Patent number: 12297847Abstract: A noise-reducing and nonuniform tip clearance structure of centrifugal compressor is provided, which includes a compressor impeller body and a compressor impeller shroud. The compressor impeller shroud is circumferentially wrapped outside the compressor impeller body, and multiple impeller blade bodies are uniformly arranged in a circumferential direction of the compressor impeller body. A clearance between an impeller tip meridian line of the impeller blade body and an impeller shroud meridian line on the compressor impeller shroud is an impeller tip clearance. The impeller tip clearance gradually decreases in a direction from a leading edge to a trailing edge of the impeller blade body, and a change rate of the impeller tip clearance in the direction from the leading edge to the trailing edge of the impeller blade body also gradually decreases.Type: GrantFiled: November 8, 2024Date of Patent: May 13, 2025Assignee: Harbin Engineering UniversityInventors: Yipeng Cao, Shaoran Du, Chen Liu, Yao Song, Jie Yang, Xiaochen Zhao, Jie Guo, Xinyu Zhang
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Patent number: 12276242Abstract: Provided is an intake bypass recirculation structure capable of silencing, including: an intake bypass recirculation structure body and a structure-conducted silencing device. An intake bypass recirculation cavity is provided on the intake bypass recirculation structure body. An inlet of the intake bypass recirculation structure and an outlet of the intake bypass recirculation structure that are provided on the intake bypass recirculation structure body are each connected to the intake bypass recirculation cavity. The structure-conducted silencing device is disposed inside the intake bypass recirculation cavity. In this application, during working, noise generated by a compressor is transmitted into the intake bypass recirculation cavity via an inlet of the intake bypass recirculation structure, and transmitted outside via the outlet of the intake bypass recirculation structure.Type: GrantFiled: December 18, 2024Date of Patent: April 15, 2025Assignee: Harbin Engineering UniversityInventors: Yipeng Cao, Yao Song, Chen Liu, Xiaochen Zhao, Jiaxuan Lin, Shaoran Du, Jie Yang, Jie Guo, Xinyu Zhang
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Publication number: 20250057948Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.Type: ApplicationFiled: June 6, 2024Publication date: February 20, 2025Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Publication number: 20240252629Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.Type: ApplicationFiled: January 25, 2024Publication date: August 1, 2024Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Patent number: 11946485Abstract: Some embodiments of the disclosure provide an air intake bypass recirculation structure with adjustable air entraining amount and controllable broadband noise which includes main body of the air intake bypass recirculation structure and an air entraining amount adjusting structure. In some examples, an air intake bypass recirculation cavity is formed in the main body of the air intake bypass recirculation structure. An air inlet of an air intake pipe and an air outlet of the air intake pipe are formed in two ends of the main body of the air intake bypass recirculation structure respectively. An airflow inlet of the air intake bypass recirculation structure and an airflow outlet of the air intake bypass recirculation structure are formed in the inner side of the main body of the air intake bypass recirculation structure. The air entraining amount adjusting structure is arranged in the air intake bypass recirculation cavity.Type: GrantFiled: August 14, 2023Date of Patent: April 2, 2024Assignee: Harbin Engineering UniversityInventors: Chen Liu, Zequn Ma, Yipeng Cao, Runze Zhang, Xinyu Zhang, Wenping Zhang, Jie Yang, Changhong Sun, Jie Guo, Xiaochen Zhao, Gongmin Liu
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Patent number: 11905916Abstract: A turbocharger air intake silencer with adjustable cavity space structures is provided. The turbocharger air intake silencer comprises a silencer connecting flange and a first resonator device. The first resonator device comprises a first silencer sealing plate, a first annular sound absorption cavity body, a first rotary table, a first rotary steering gear and a first valve. A first sound absorption cavity is enclosed by the first silencer sealing plate, the first annular sound absorption cavity body, the first valve and the first rotary table. A first sound absorption cavity inlet pipe is arranged beside the first sound absorption cavity. The first sound absorption cavity and the first sound absorption cavity inlet pipe form a Helmholtz resonator. The first rotary steering gear is mounted on the silencer connecting flange. The rotary steering gear is connected with a first rotary rack.Type: GrantFiled: August 1, 2023Date of Patent: February 20, 2024Assignee: HARBIN ENGINEERING UNIVERSITYInventors: Yipeng Cao, Zequn Ma, Chen Liu, Runze Zhang, Xinyu Zhang, Wenping Zhang, Zhuoyan Feng, Yuan Gao, Xiaochen Zhao, Gongmin Liu
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Publication number: 20240052849Abstract: Some embodiments of the disclosure provide an air intake bypass recirculation structure with adjustable air entraining amount and controllable broadband noise which includes main body of the air intake bypass recirculation structure and an air entraining amount adjusting structure. In some examples, an air intake bypass recirculation cavity is formed in the main body of the air intake bypass recirculation structure. An air inlet of an air intake pipe and an air outlet of the air intake pipe are formed in two ends of the main body of the air intake bypass recirculation structure respectively. An airflow inlet of the air intake bypass recirculation structure and an airflow outlet of the air intake bypass recirculation structure are formed in the inner side of the main body of the air intake bypass recirculation structure. The air entraining amount adjusting structure is arranged in the air intake bypass recirculation cavity.Type: ApplicationFiled: August 14, 2023Publication date: February 15, 2024Applicant: Harbin Engineering UniversityInventors: Chen LIU, Zequn MA, Yipeng CAO, Runze ZHANG, Xinyu ZHANG, Wenping ZHANG, Jie YANG, Changhong SUN, Jie GUO, Xiaochen ZHAO, Gongmin LIU
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Publication number: 20240044306Abstract: A turbocharger air intake silencer with adjustable cavity space structures is provided. The turbocharger air intake silencer comprises a silencer connecting flange and a first resonator device. The first resonator device comprises a first silencer sealing plate, a first annular sound absorption cavity body, a first rotary table, a first rotary steering gear and a first valve. A first sound absorption cavity is enclosed by the first silencer sealing plate, the first annular sound absorption cavity body, the first valve and the first rotary table. A first sound absorption cavity inlet pipe is arranged beside the first sound absorption cavity. The first sound absorption cavity and the first sound absorption cavity inlet pipe form a Helmholtz resonator. The first rotary steering gear is mounted on the silencer connecting flange. The rotary steering gear is connected with a first rotary rack.Type: ApplicationFiled: August 1, 2023Publication date: February 8, 2024Inventors: YIPENG CAO, ZEQUN MA, CHEN LIU, RUNZE ZHANG, XINYU ZHANG, WENPING ZHANG, ZHUOYAN FENG, YUAN GAO, XIAOCHEN ZHAO, GONGMIN LIU
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Publication number: 20240024471Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.Type: ApplicationFiled: August 21, 2023Publication date: January 25, 2024Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Publication number: 20240000934Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.Type: ApplicationFiled: August 21, 2023Publication date: January 4, 2024Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Publication number: 20220233689Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.Type: ApplicationFiled: December 27, 2021Publication date: July 28, 2022Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano Huang, Thomas Arthur Haby, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO
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Publication number: 20220233693Abstract: The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition.Type: ApplicationFiled: December 27, 2021Publication date: July 28, 2022Applicants: Bristol-Myers Squibb Company, Halozyme, Inc.Inventors: Masano HUANG, Thomas Arthur HABY, Mehrnaz KHOSSRAVI, Scott Aaron HART, Rao Venkatramana MANTRI, Heather Elizabeth VEZINA, Amit ROY, Bindu Purnima MURTHY, Urvi Ashish ARAS, Kinjal SANGHAVI, Xiaochen ZHAO, Akintunde BELLO