Patents by Inventor Xiaocong Yu

Xiaocong Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IgA CD4i ANTIBODIES AND METHODS OF TREATMENT USING SAME
    Publication number: 20150175678
    Abstract: The present invention relates to isolated IgA antibodies, or fragments thereof, which have variable domains derived from an antibody that specifically binds to a CD4-induced (CD4i) epitope. In particular, the isolated IgA antibodies display enhanced neutralization activity relative to their IgG, non-chimeric counterparts. The invention also provides methods for therapy with the isolated IgA antibodies for the treatment of a subject having a viral infection or having an increased risk of a viral infection.
    Type: Application
    Filed: June 17, 2013
    Publication date: June 25, 2015
    Inventors: Lisa Cavacini, Marshall Posner, Xiaocong Yu
  • Anti human ovarian cancer-anti CD3 bispecific antibody
    Publication number: 20080138339
    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
    Type: Application
    Filed: August 22, 2007
    Publication date: June 12, 2008
    Inventors: Hualiang Huang, Xin Jiang, Min Fang, Jie Feng, Ping Zhou, Xiaocong Yu, Qing Lin
  • Anti human ovarian cancer-anti CD3 bispecific antibody
    Patent number: 7262276
    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: August 28, 2007
    Assignee: Beijing ABT Genetic Engineering Technology Co. Ltd.
    Inventors: Hualiang Huang, Xin Jiang, Min Fang, Xiaocong Yu, Jie Feng, Ping Zhou, Qing Lin
  • Anti human ovarian cancer-anti cd3 bispecific antibody
    Publication number: 20050255115
    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
    Type: Application
    Filed: May 23, 2002
    Publication date: November 17, 2005
    Inventors: Hualiang Huang, Xin Jiang, Min Fang, Jie Feng, Ping Zhou, Xiaocong Yu, Qing Lin