Patents by Inventor Xiaocui XIE

Xiaocui XIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered microorganisms expressing acetoacetyl-CoA reductase variants and method for improving the yield of PHA
    Patent number: 11913056
    Abstract: Provided is engineered microorganisms expressing acetoacetyl-CoA reductase variants and a method for improving the yield of PHA. Compared with the wild-type acetoacetyl-CoA reductase represented by SEQ ID NO. 31, the variant has one or more of the following mutations: (1) mutation of valine at position 141 to isoleucine or leucine; (2) mutation of methionine at position 12 to threonine, serine, alanine, leucine, lysine or isoleucine; (3) mutation of isoleucine at position 194 to valine, leucine or methionine; (4) mutation of glutamic acid at position 42 to lysine, glutamine, leucine, aspartic acid, proline, threonine, asparagine, or histidine; and (5) mutation of phenylalanine at position 55 to valine, alanine or isoleucine. The variants and their coding genes can promote the synthesis and accumulation of PHA by the strain and increase the yield of PHA.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: February 27, 2024
    Assignee: SHENZHEN BLUEPHA BIOSCIENCES CO., LTD.
    Inventors: Jin Yin, Yu Wang, Xiaocui Xie, Huayu Zhang, Yakun Wu, Tian Liu, Pingan Tang
  • Engineered microorganisms expressing acetoacetyl-CoA reductase variants and method for improving the yield of PHA
    Publication number: 20230323411
    Abstract: Provided is engineered microorganisms expressing acetoacetyl-CoA reductase variants and a method for improving the yield of PHA. Compared with the wild-type acetoacetyl-CoA reductase represented by SEQ ID NO. 31, the variant has one or more of the following mutations: (1) mutation of valine at position 141 to isoleucine or leucine; (2) mutation of methionine at position 12 to threonine, serine, alanine, leucine, lysine or isoleucine; (3) mutation of isoleucine at position 194 to valine, leucine or methionine; (4) mutation of glutamic acid at position 42 to lysine, glutamine, leucine, aspartic acid, proline, threonine, asparagine, or histidine; and (5) mutation of phenylalanine at position 55 to valine, alanine or isoleucine. The variants and their coding genes can promote the synthesis and accumulation of PHA by the strain and increase the yield of PHA.
    Type: Application
    Filed: June 28, 2022
    Publication date: October 12, 2023
    Applicant: SHENZHEN BLUEPHA BIOSCIENCES CO., LTD.
    Inventors: Jin YIN, Yu WANG, Xiaocui XIE, Huayu ZHANG, Yakun WU, Tan LIU, Pingen TANG