Abstract: A modified cell, a method for preparing a modified cell, and a use thereof in treatment of a disease. The modified cell comprises a polynucleotide that encodes a presenting peptide, wherein the polynucleotide is under the transcriptional regulation of an endogenous B2M gene.

Abstract: Disclosed herein are fusion proteins having a ?2M polypeptide and a presenting peptide, and nucleic acids that encode such fusion proteins. Provided herein are also genetically engineered cells expressing such fusion protein, methods of their production, and their uses in allogeneic transplant. CAR-T cells expressing fusion protein disclosed herein and their uses in cancer treatment are also disclosed.

Abstract: The present invention relates to a proliferation enhancer. The enhancer comprises a protein molecule capable of initiating the cellular STATS and/or STAT3 signaling pathway and comprising the intracellular domain, the transmembrane domain and the extracellular domain. The present invention further relates to a lymphocyte expressing the proliferation enhancer and the use thereof as an immunotherapy drug.

Abstract: The present invention discloses a radiation detector, an imaging device and an electrode structure thereof, and a method for acquiring an image. The radiation detector comprises: a radiation sensitive film, a top electrode on the radiation sensitive film, and an array of pixel units electrically coupled to the radiation sensitive film. Each pixel unit comprises: a pixel electrode (which is configured to collect a charge signal in a pixel area of the radiation sensitive film), a storage capacitor, a reset transistor, a buffer transistor, a column strobe transistor, and a row strobe transistor. The column strobe transistor and the row strobe transistor are connected in series between the buffer transistor and the signal line, and transfer the voltage signal of the corresponding pixel unit in response to a column strobe signal and a row strobe signal. The radiation detector may be used for, for example, X-ray digital imaging.

Abstract: The present invention discloses a radiation detector, an imaging device and an electrode structure thereof, and a method for acquiring an image. The radiation detector comprises: a radiation sensitive film, a top electrode on the radiation sensitive film, and an array of pixel units electrically coupled to the radiation sensitive film. Each pixel unit comprises: a pixel electrode (which is configured to collect a charge signal in a pixel area of the radiation sensitive film), a storage capacitor, a reset transistor, a buffer transistor, a column strobe transistor, and a row strobe transistor. The column strobe transistor and the row strobe transistor are connected in series between the buffer transistor and the signal line, and transfer the voltage signal of the corresponding pixel unit in response to a column strobe signal and a row strobe signal. The radiation detector may be used for, for example, X-ray digital imaging.

Abstract: The present invention discloses a radiation detector, an imaging device and an electrode structure thereof, and a method for acquiring an image.