Patents by Inventor Xiaodan Li

Xiaodan Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12018078
    Abstract: Provided are a murine or fully human monoclonal antibody targeting SEMA4D and a preparation method therefor, wherein the antibody binds to the SEMA4D antigen and has activities such as combating tumors.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: June 25, 2024
    Assignee: JIANGSU HUAIYU PHARMACEUTICAL CO., LTD.
    Inventors: Yingying Hu, Xiaodan Cao, Zihan Jin, Lina Wang, Yuandong Wang, Xiaohui Shao, Shaoping Hu, Mingming Pan, Yan Liu, Wei Shao, Yanyan Li, Xiaoxuan Lan, Ying Gu, Siran Zhu, Lile Liu, Qing Duan
  • Publication number: 20240190743
    Abstract: A method for treating alkaline fluorine-containing wastewater by combining an induced crystallization method with a tubular membrane filter (TMF) includes: introducing fluorine-containing wastewater into a regulating pond to regulate to 8.0-8.
    Type: Application
    Filed: January 27, 2024
    Publication date: June 13, 2024
    Inventors: Gong Cheng, Sai Wang, Xiaodan Chen, Wei Li, Tuantuan Wang, Rui Lin, Yiwen Luo, Yi Chen
  • Patent number: 11993561
    Abstract: The present disclosure discloses an expectorant compound, and specifically discloses compounds represented by formula I and formula II, pharmaceutically acceptable salts or tautomers thereof.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: May 28, 2024
    Assignee: HC SYNTHETIC PHARMACEUTICAL CO., LTD.
    Inventors: Cheng Yang, Sumin Qi, Qiyuan Zhang, Dongxing Li, Tieshan Chen, Xiaodan Zhao
  • Publication number: 20240167004
    Abstract: Provided are a highly specific Taq DNA polymerase variant and the use thereof in genome editing and gene mutation detection. All polar amino acids, directly interacting with a primer/template complex, on a Taq enzyme are selected to be mutated one by one to obtain 40 Taq variants, and extensive random mutagenesis is performed on the basis of the sequences of the variants and the sequences of wild type Taq enzymes to create a Taq mutant library. Then, a series of Taq mutants with a high specificity are screened on a qPCR screening system by means of taking a genome editing indels plasmid as a template, wherein the Taq mutants exhibit great advantages in CRISPR/Cas9 editing efficiency evaluation and single-cell cloning genotyping.
    Type: Application
    Filed: July 15, 2021
    Publication date: May 23, 2024
    Applicants: SHANGHAI TURTLE TECHNOLOGY CO., LTD., SHANDONG UNIVERSITY
    Inventors: Qilai HUANG, Xiaodan LIU, Ping DU, Bo LI
  • Publication number: 20240167947
    Abstract: The present invention discloses a CEEMDAN-based method for screening and monitoring soil moisture stress in farmland, characterised by the steps: preprocessing of remote sensing images, construction of NDVI long time series, CEEMDAN decomposition, calculation of statistical descriptors, screening of soil moisture stress sequences, ground data measurement, construction of soil moisture stress characteristic curves, fitting of soil moisture stress response characteristic curves and predicting the content of soil moisture stress. The invention adopts CEEMDAN decomposition, which solves the problems of noise residue and low reconstruction accuracy in the previous methods, and the high reconstruction accuracy of decomposed component data is more conducive to capturing the transient effects of soil moisture stress, and realizes the screening and extraction of soil moisture stress by combining with the ground measured data.
    Type: Application
    Filed: May 5, 2023
    Publication date: May 23, 2024
    Inventors: Xuqing Li, Yongtao Jin, Xiaodan Wang, Guohong Li, Xingfa Gu, Yuanping Liu, Xia Zhu, Qichao Zhao, Yuyan Liu, Xiufeng Yang, Yancang Wang, Tianjiao Liu, Wenhao Zhang, Chenyu Zhao
  • Publication number: 20240150346
    Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 9, 2024
    Inventors: Yunlong SONG, Chen ZHANG, Fang GAO, Weimin LIU, Qun DANG, Pan LI, Zhou YIN, Xin CAI, Xiaodan FU, Jianbin MA
  • Publication number: 20240139742
    Abstract: The planetary outbreak of COVID-19 has led to a substantial death toll and has hindered the functioning of modern society. This underlines the importance of accurate, cost-effective serological antibody tests and point-of-care diagnostics to monitor the viral spread and to contain pandemics and endemics. This requires a cost-effective three-dimensional nanofluidic device for rapid and multiplexed detection of viral antibodies. The device is configured to size-dependently immobilize particles at predefined positions from a multiparticle mixture, giving rise to distinct trapping lines. It is shown with the device that distinctive lines can be used as an on-chip and on-bead fluorescent linked immunosorbent assay for the detection of immunoglobulin G (IgG) antibodies against the receptor-binding domain of SARS-CoV-2 in human serum.
    Type: Application
    Filed: May 2, 2022
    Publication date: May 2, 2024
    Inventors: Thomas Mortelmans, Yasin Ekinci, Xiaodan Li
  • Publication number: 20240076690
    Abstract: A group of viral vectors including: first viral vector, wherein first viral vector carries first nucleic acid molecule, and the first nucleic acid molecule encodes envelope protein; second viral vector, wherein second viral vector carries second nucleic acid molecule, the second nucleic acid molecule encodes fusion protein, the fusion protein includes single-chain antibody and C-terminal domain of envelope protein, the C-terminal domain of envelope protein includes transmembrane region and intracellular region of envelope protein, the C-terminus of single-chain antibody connects with N-terminus of C-terminal domain of envelope protein, the single-chain antibody targets a specific antigen; first nucleic acid molecule and second nucleic acid molecule are arranged to express envelope protein and fusion protein, and the envelope protein and the fusion protein are in non-fusion form.
    Type: Application
    Filed: September 29, 2021
    Publication date: March 7, 2024
    Applicant: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Xiaodan YANG, Shiyou CHEN, Xiuqin ZHU, Junji DONG, Xiaofeng CHEN, Wenjia LI
  • Publication number: 20240070436
    Abstract: A method is provided for data processing performed by a processing system. The method comprises determining a set of first tokens for first data and a set of second token for second data, each token comprising information associated with a segment of the respective data, determining pair-wise similarities between the set of first tokens and the set of second tokens, each pair comprising a first token in the set of first tokens and a second token in the set of second tokens, determining, for each first token in the set of first tokens, a maximum similarity based on the determined pair-wise similarities between the respective first token and the second tokens in the set of second tokens, and determining a first similarity between the first data and the second data by aggregating the maximum similarities corresponding to the first tokens in the set of first set of tokens.
    Type: Application
    Filed: August 31, 2022
    Publication date: February 29, 2024
    Inventors: Hang XU, Lu HOU, Guansong LU, Minzhe NIU, Zhenguo LI, Runhui HUANG, Lewei YAO, Chunjing XU, Xiaodan LIANG
  • Patent number: 11290494
    Abstract: Methods and systems for reliability prediction of security policies in a cloud computing environment are provided. An example method includes providing a graph database representing workloads of the cloud computing environment as nodes and relationships between the workloads as edges, the relationships being associated with points in time, receiving a security policy including rules for the relationships between the workloads, generating a plurality of earliest points in time based on the rules and the graph database, wherein generating the plurality of earliest points in time includes: determining, for each rule of the rules, a subset of the relationships in the graph database such that each of the subset of the relationships matches the rule, and selecting an earliest point in time from points in time associated with relationships from the subset, and analyzing the plurality of earliest points in time to determine a reliability score for the security policy.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: March 29, 2022
    Assignee: vArmour Networks, Inc.
    Inventors: Xiaodan Li, Marc Woolward
  • Publication number: 20220007682
    Abstract: A method for preparing IPP- and VPP-rich hydrolysate from wheat gluten protein by enzymatic hydrolysis is disclosed, comprising the following steps: (1) dissolving wheat gluten protein in an alkaline solution, and performing ultrasonic treatment; (2) adding the alkaline protease to the wheat gluten protein solution to hydrolyze; (3) adjusting the pH value of the alkaline hydrolysate to neutral or weakly acidic, and adding protease to hydrolyze, and inactivating the enzyme at a high temperature; (4) centrifuging the hydrolysate to obtain the supernatant, and ultrafiltrating with an ultrafiltration membrane; (5) decolorizing and debitterizing the permeate using a macroporous resin; (6) after the debittered and decolorized liquid is adsorbed by an ion exchange resin, eluting the ion exchange resin and drying, to obtain a powder of IPP- and VPP-rich hydrolysate. The preparation method has a high protein recovery rate, with rich IPP and VPP in the hydrolysate.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 13, 2022
    Inventors: Guoqing Huang, Junxia Xiao, Zhikai Zhang, Huiqin Zhou, Liping Guo, Xiaodan Li, Jing Teng
  • Publication number: 20200382557
    Abstract: Methods and systems for reliability prediction of security policies in a cloud computing environment are provided. An example method includes providing a graph database representing workloads of the cloud computing environment as nodes and relationships between the workloads as edges, the relationships being associated with points in time, receiving a security policy including rules for the relationships between the workloads, generating a plurality of earliest points in time based on the rules and the graph database, wherein generating the plurality of earliest points in time includes: determining, for each rule of the rules, a subset of the relationships in the graph database such that each of the subset of the relationships matches the rule, and selecting an earliest point in time from points in time associated with relationships from the subset, and analyzing the plurality of earliest points in time to determine a reliability score for the security policy.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 3, 2020
    Inventors: Marc Woolward, Xiaodan Li
  • Publication number: 20200065553
    Abstract: The present disclosure relates to a remote sensing system which comprises at least a plurality of UAVs or drones to construct a measurement matrix in space for compressed sensing algorithms. A single remote sensor or a plural remote sensors is carried by each of UAV or drone in the fleet and can be independently turned on or turned off. Each UAV or drone in the fleet works as a floating pixel in said sparse measurement matrix, to output sampling data for processing and reconstruction of sensing image by said compressed sensing algorithm.
    Type: Application
    Filed: August 26, 2018
    Publication date: February 27, 2020
    Inventors: BUJIN GUO, XIAODAN LI, JAMES M. GUO
  • Publication number: 20190181797
    Abstract: The present invention provides a smart power supply system including an open storage chamber, a rail, and photovoltaic umbrellas each including a plurality of photovoltaic umbrella panels. The photovoltaic umbrellas may be stored in the storage chamber; the storage chamber is connected to the rail via an opening. When in use, the photovoltaic umbrellas are moved upward from the storage chamber to the rail, then photovoltaic umbrella panels of the photovoltaic umbrellas are expanded. During storage, the photovoltaic umbrella panels of the photovoltaic umbrellas are collapsed, then the photovoltaic umbrellas move downwards along the rail and are then stored in the storage chamber. In the present invention, when use of the photovoltaic umbrellas is required, the photovoltaic umbrellas are expanded outdoor; under certain circumstances such as raining and typhoon, the photovoltaic umbrellas are stored indoor to prevent damages caused to the photovoltaic umbrellas.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 13, 2019
    Inventors: Xiangxing Zeng, Baofeng Miao, Xiaodan Li, Wu Chen, Xiaofei Zou, Xiang Zhang, Zhaojun Ye, Huatan Wu, Wenliang Chen, Lianfa Zhang
  • Patent number: 7097315
    Abstract: A method, apparatus and system for polarization conversion and recycling by using a half-pyramid shaped reflector with multiple reflective surfaces, or said reflector assembly, to obtain a desirable polarization rotation effect. The disclosed half-pyramid reflector comprises a plurality of reflective surfaces, which are formed so that an incoming beam passing perpendicularly through the entrant surface is reflected three times inside the device and leaves the exit surface with the direction of polarization being rotated 90 degrees. The preferred embodiments of polarization:conversion systems using the invented apparatus are included. Without employing any waveplate component, the disclosed system is not sensitive to wavelength variations of the light source, temperature changes, and polarization alignment errors.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: August 29, 2006
    Assignee: Microsensor Technology
    Inventors: Haizhang Li, Bujin Guo, Xiaodan Li
  • Publication number: 20040090763
    Abstract: A method, apparatus and system for polarization conversion and recycling by using a half-pyramid shaped reflector with multiple reflective surfaces, or said reflector assembly, to obtain a desirable polarization rotation effect. The disclosed half-pyramid reflector comprises a plurality of reflective surfaces, which are formed so that an incoming beam passing perpendicularly through the entrant surface is reflected three times inside the device and leaves the exit surface with the direction of polarization being rotated 90 degrees. The preferred embodiments of polarization conversion systems using the invented apparatus are included. Without employing any waveplate component, the disclosed system is not sensitive to wavelength variations of the light source, temperature changes, and polarization alignment errors.
    Type: Application
    Filed: April 2, 2003
    Publication date: May 13, 2004
    Applicant: Microsensor Technology
    Inventors: Haizhang Li, Bujin Guo, Xiaodan Li