Abstract: Some embodiments of the present disclosure provide manufacturing methods for a wheel rim, a spoke and a steel wheel and a steel wheel formed by the methods. The methods includes that: a wheel rim/a spoke blank is heated in a heating furnace, and the heated wheel rim/the heated spoke blank is transferred onto a hot press. A temperature of the wheel rim/the spoke blank being required to be kept above a required temperature in a process of transferring the heated wheel rim/the heated spoke blank to the hot press. Then the wheel rim/the spoke blank is formed in the hot press. A formed wheel rim and a formed spoke are connected to product a steel wheel.

Abstract: This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Abstract: A method for mixing a first substance of a first chamber of a syringe and a second substance of a second chamber of the syringe, wherein communication of the first chamber and the second chamber is blocked by a removable member, the method including positioning the first chamber at an elevation higher than the second chamber; removing the removable member to enable communication of the first substance with the second substance to form a mixture; positioning the second chamber at an elevation higher than the first chamber; and replacing the removable member to confine the mixture in the first chamber.

Abstract: A syringe including a first hollow cylinder including a first end, a second end and a first inner diameter; a second hollow cylinder including a first end, a second end and a second inner diameter, wherein the second end of the second hollow cylinder is fixed with respect to the first end of the second hollow cylinder; a tube including a first end having the first inner diameter and a second end having the second inner diameter, wherein the tube is configured to connect the first hollow cylinder at the second end of the first hollow cylinder and the second hollow cylinder at the first end of the second hollow cylinder; and a piston configured to slide within the first hollow cylinder, the tube and the second hollow cylinder.

Abstract: Some embodiments of the present disclosure provide manufacturing methods for a wheel rim, a spoke and a steel wheel and a steel wheel formed by the methods. The methods includes that: a wheel rim/a spoke blank is heated in a heating furnace, and the heated wheel rim/the heated spoke blank is transferred onto a hot press. A temperature of the wheel rim/the spoke blank being required to be kept above a required temperature in a process of transferring the heated wheel rim/the heated spoke blank to the hot press. Then the wheel rim/the spoke blank is formed in the hot press. A formed wheel rim and a formed spoke are connected to product a steel wheel.

Abstract: Disclosed herein are primers and probes for the detection of single nucleotide polymorphisms (SNPs) in the KRAS gene. These primers and probes may be used in a method of identifying the presence or absence of one or more SNPs in the KRAS gene. These primers and probes may also be used in a method of predicting a response of a subject in need thereof to a cancer therapy. The primers and probes may further be used in a method of selecting a cancer therapy for a subject in need thereof.

Abstract: Disclosed herein are primers and probes for the detection of single nucleotide polymorphisms (SNPs) in the KRAS gene. These primers and probes may be used in a method of identifying the presence or absence of one or more SNPs in the KRAS gene. These primers and probes may also be used in a method of predicting a response of a subject in need thereof to a cancer therapy. The primers and probes may further be used in a method of selecting a cancer therapy for a subject in need thereof.

Abstract: This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Abstract: Disclosed herein are primers and probes for the detection of single nucleotide polymorphisms (SNPs) in the KRAS gene. These primers and probes may be used in a method of identifying the presence or absence of one or more SNPs in the KRAS gene. These primers and probes may also be used in a method of predicting a response of a subject in need thereof to a cancer therapy. The primers and probes may further be used in a method of selecting a cancer therapy for a subject in need thereof.