Abstract: Provided herein are bilobalide derivative compounds, processes for making, methods of using, and uses thereof for preventing or treating neurological disease and cancer.

Abstract: Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can form covalent adducts with reactive nucleophilic amino acid residues, e.g., reactive tyrosines and reactive lysines, in kinases to form modified kinases and/or alter the biological activity of the kinases. Kinases targetable by the compounds include cyclin-dependent kinase 2 (CDK2), diacylglycerol kinases (DGKs), and phosphofructokinase (PFK). Pharmaceutical compositions including the compounds and methods of inhibiting kinases are also described.

Abstract: The present disclosure relates to a technical field of chiral compound synthesis, and particularly to chiral or racemic pyrimidine-fused diazepinone derivatives, preparation method, and application thereof. A structural formula of the chiral or racemic pyrimidine-fused diazepinone derivatives or pharmaceutically acceptable salts thereof is as shown in formula (I), The present disclosure further provides a preparation method of the chiral or racemic pyrimidine-fused diazepinone derivatives, the method includes using pyrimidine allyl compound intermediates as raw materials, using iridium complexes formed by an interaction between iridium compounds and phosphoramidite ligands as catalysts, and obtaining the chiral or racemic pyrimidine-fused diazepinone derivatives by reactions under action of alkalis.