Abstract: The present invention relates to methods and compositions for specifically modulating the Hippo pathway transcription factor TAZ (WWTR1), as a therapeutic target for inhibiting or preventing liver conditions including the progression of steatosis-to-NASH in a patient.

Abstract: Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.

Abstract: Nanoparticulate pharmaceutical formulations and methods for co-delivery of two or more species of nucleic acids for simultaneous suppression and expression of target genes in a cell, are provided. The nanoparticles encapsulate two or more nucleic acid species. The first nucleic acid suppresses expression of a gene or product thereof, e.g., inhibitory nucleic acid, such as antisense, siRNA, miRNA, Dicer siRNA, piRNA, etc. The second nucleic acid increases expression of, or encodes, an endogenous or exogenous protein or polypeptide, e.g., an mRNA. The first and second nucleic acid species simultaneously target or affect the same or different cellular processes within a cell including communication, senescence, DNA repair, gene expression, metabolism, necrosis, and apoptosis.

Abstract: This invention relates to amphiphile-polymer particles, compositions, methods of making, and methods of use thereof.

Abstract: Nanoparticulate pharmaceutical formulations and methods for co-delivery of two or more species of nucleic acids for simultaneous suppression and expression of target genes in a cell, are provided. The nanoparticles encapsulate two or more nucleic acid species. The first nucleic acid suppresses expression of a gene or product thereof, e.g., inhibitory nucleic acid, such as antisense, siRNA, miRNA, Dicer siRNA, piRNA, etc. The second nucleic acid increases expression of, or encodes, an endogenous or exogenous protein or polypeptide, e.g., an mRNA. The first and second nucleic acid species simultaneously target or affect the same or different cellular processes within a cell including communication, senescence, DNA repair, gene expression, metabolism, necrosis, and apoptosis.

Abstract: This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.

Abstract: Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.

Abstract: This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.

Abstract: Nanoparticles containing an aqueous core containing one or more nucleic acids, such as siRNA, and a shell containing one or more hydrophobic cationic materials, one or more amphiphilic materials, and one or more therapeutic, diagnostic, and/or prophylactic agents are. The hydrophobic cationic material and the hydrophobic portion of the amphiphilic material provide a non-polar polymer matrix for loading non-polar drugs, protect and promoting siRNA molecule retention inside the NP core, and control drug release. The hydrophilic portion of the amphiphilic material can form a corona around the particle which prolongs circulation of the particles in the blood stream and decreases uptake by the RES.

Abstract: A method in one embodiment includes allocating, by a node of a network, a flow label attribute identifying a media flow associated with a Session Description Protocol (SDP) media session. The media flow is between a sender and receiver nodes over a media transmission path of the network. The node further specifying a flow state attribute to generate media flow information and communicating the flow label and the flow state attribute to downstream nodes in the media transmission path. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure.

Abstract: In one embodiment, a method and system for enabling determination of a physical location of a Voice Over Internet Protocol (VoIP) endpoint device utilized to originate an emergency call are described. A network location associated with the VoIP endpoint device is automatically detected. The VoIP endpoint device is coupled with a VoIP network via a port of a network device (e.g., a wireline or a wireless network device). The network location includes an identity of the network device and an identity of the port. The network location is saved and upon initiation of an emergency call, the VoIP endpoint device forwards the network location to a device capable of converting the network location to a physical location.

Abstract: A node for routing of calls in a network has an interface coupled to the network and at least one processor operable to route a packet-based call to a telephony destination in accordance with a protocol that includes a set of attributes that describe packet-network routing characteristics of one or more Internet Protocol (IP)-IP gateway devices in the network. The attributes are used by the at least one processor to specify a call route through an IP-IP gateway device for the packet-based call. The set of attributes include a first attribute that identifies a total administratively provisioned bandwidth capacity available on a given call route to accommodate application traffic, and a second attribute that identifies a current bandwidth that is available on the given call route to accommodate the application traffic at a given point in time.

Abstract: A method for providing a handoff in a network environment is provided that includes a mobile station operable to conduct a call. The mobile station is further operable to initiate a call leg autonomously such that a generic transfer function is invoked. The mobile station leverages the generic transfer function in order to execute a handoff for the mobile station.

Abstract: A device and method provides a means for monitoring a media segment of a Real-time Transport Protocol (RTP) media stream without interfering with end-to-end monitoring of the RTP media stream. The device includes a media segment monitor to generate segment control messages associated with a selected segment of the RTP media stream transmitted between a source endpoint and a destination endpoint in a packet network. The device further includes an interface to transmit and receive the segment control messages; and a processor to process the segment control messages, the segment control messages including call quality metrics related to the selected segment of the RTP media stream.

Abstract: A system for aggregating packet in a Medium Access control layer of a router to improve effective bandwidth of transmission over a network. The system begins by receiving Medium Access Control Service Data Unit packets in a Medium Access Control unit of a router wherein each of the Medium Access Control Service Data Unit packets are addressed to different receivers. The Medium Access Control Service Data Unit packets are then aggregated into one Medium Access Control Protocol Data Unit packet. The Medium Access Control Protocol Data Unit packet is then transmitted to said Physical layer of said router for transmission.

Abstract: An access point of a wireless network broadcasts directory information including a schedule on a first broadcast channel about media programs being broadcast on other channels by the access point. The broadcast on the first channel provides for sleep-mode clients to receive the broadcast. A client receives the schedule, and in order to receive a particular media program at a scheduled time switches to a particular one of the other channels and to wakeup state to receive a particular program.

Abstract: Embodiments of the invention include a method and software for pre-allocating bandwidth for time-sensitive data such as voice data, for allocating some of the pre-allocated bandwidth to calls, and for timely delivery of frames that include time-sensitive data such as voice data in both the uplink and downlink direction for calls between an access point, e.g., a quality-assured access point (Q-AP) and one or more of its client stations.

Abstract: An apparatus and method for switching a mobile processing device from communicating over a wireless connection with a first base unit to a second base unit based upon latency. In accordance with this invention, the mobile processing device determines latency information for packets being transmitted over the wireless connection to and from a base unit. The latency information is compared to a threshold value. If the latency information is greater than the threshold value, the mobile processing device adjusts parameters of the wireless connection between the mobile processing device and the network.

Abstract: A method, an apparatus, and code in a carrier medium to operate in a first access point of a wireless network in communication with at least one associated client station. The method includes wirelessly broadcasting a management frame including an indication that the first access point will stop being active, such that each associated client station can wirelessly roam to a second access point prior to the first access point ceasing being active. One embodiment further includes reducing the transmit power of wireless communication used to wirelessly transmit information to the associated client stations, such that each associated client station can eventually wirelessly roam to the second access point.

Abstract: A node for routing of calls in a network has an interface coupled to the network and at least one processor operable to route a packet-based call to a telephony destination in accordance with a protocol that includes a set of attributes that describe packet-network routing characteristics of one or more Internet Protocol (IP)-IP gateway devices in the network. The attributes are used by the at least one processor to specify a call route through an IP-IP gateway device for the packet-based call. The set of attributes include a first attribute that identifies a total administratively provisioned bandwidth capacity available on a given call route to accommodate application traffic, and a second attribute that identifies a current bandwidth that is available on the given call route to accommodate the application traffic at a given point in time.