Abstract: The present disclosure provides antibody drug conjugates comprising antibodies and antigen-binding fragments thereof that bind to human CEA and a linker-payload, a pharmaceutical composition comprising the anti-CEA antibody drug conjugate, and use of the anti-CEA antibody drug conjugate for treating a CEA-related diseases or disorders.

Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

Abstract: Embodiments of this application provide a positioning method and apparatus. The method includes: A first device receives, in a first system, a first trigger message for starting a positioning procedure. If the first device detects a first event, and the first device access a second system or moves to the second system, the first device sends a first message applicable to the second system. In addition, the first message includes location quality of service (QoS) applicable to the second system. According to this method, a device in the second system can recognize the first message and first location QoS, so that the device in the second system can continue a location service, to maintain continuity of the location service.

Abstract: The invention provides a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

Abstract: The present disclosure provides a display control method of a spliced screen including a plurality of sub-display screens, including: sending a display control signal to each sub-display screen in a wireless sending manner according to a time code signal; receiving, by each sub-display screen, the display control signal in a wired receiving manner, and reporting status information of each sub-display screen to the display controller; and controlling, by the display controller, displaying of each sub-display screen according to the status information of each sub-display screen, where the time code signal indicates a current time point; the display control signal is configured for controlling the sub-display screen to perform corresponding display processing on display content stored, so that the sub-display screens display a target display content together. The present disclosure further provides a display control device, a display system, an electronic device, and a computer readable storage medium.

Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

Abstract: The present invention discloses a gene mining method and system based on transcriptome and DNA methylome. The gene mining method comprises: acquiring samples; performing transcriptome sequencing on the samples and analyzing data obtained by the sequencing to obtain differentially expressed genes; performing DNA methylation sequencing on the samples and analyzing data obtained by the sequencing to obtain differentially methylated genes; performing gene function enrichment on the obtained differentially expressed genes and differentially methylated genes to obtain a molecular protein-protein interaction (PPI) network; and performing gene clustering with the molecular PPI network to identify target genes. The present invention solves the problems that it takes time and effort to mine core genes of existing transcriptome and methylome and the result is not accurate enough. The present invention mines target genes by organically integrating originally isolated transcriptome data and DNA methylome data.

Abstract: A display panel includes a display area (110) and a non-display area (120), wherein the non-display area (120) includes a first non-display area; a signal line layer (200) is arranged on a side of a base substrate (100); a touch layer (300) is arranged on a side of the signal line layer (200) away from the base substrate (100), and includes a plurality of touch lines (310), wherein, in at least part of the touch lines (310) in the first non-display area, a first touch line (311) and a second touch line (312) belonging to the same touch line (310) respectively have a first center line O1 and a second center line O2, and in a direction perpendicular to the extension of the touch line (310), the first center line O1 and the second center line O2 are not aligned.

Abstract: Embodiments of this specification provide an FHE chip and a computing device. The FHE chip includes a MIN and n PEs, and n is an integer greater than 1. The n PEs are configured to execute n operation tasks that belong to a ciphertext operation in parallel in a process of performing the ciphertext operation on target ciphertext by the FHE chip, where the target ciphertext is obtained by processing raw data based on an FHE algorithm. The MIN is configured to support a first PE in transmitting switching data to a second PE, where the switching data belongs to an operation result generated by the first PE by executing the operation task, and the first PE and the second PE belong to the n PEs.

Abstract: A display panel and display apparatus, display panel includes an array substrate. Array substrate includes substrate and has display region. Display region includes color filter, pixel electrode, and first transistor that are located on same side of substrate. First transistor includes first semiconductor layer. Along direction perpendicular to plane of substrate, color filter is located between first semiconductor layer and pixel electrode, and first semiconductor layer is electrically connected to pixel electrode through first connecting portion. First connecting portion includes first connecting sub-portion in first connecting hole. Orthographic projection of first connecting sub-portion on plane of substrate does not overlap with orthographic projection of color filter on plane of substrate. Along direction parallel to plane of substrate, first connecting sub-portion at least partially overlaps with color filter.

Abstract: A display apparatus includes a display panel, a mirror switching screen, a first photosensitive sensor, a first flexible circuit board and a driver board. The mirror switching screen is disposed on a light-exit side of the display panel. The first photosensitive sensor is configured to sense a light intensity of ambient light at a side of the mirror switching screen away from the display panel. The first flexible circuit board includes a bonding portion, a component portion and a wiring portion. The bonding portion is electrically connected to the mirror switching screen. The first photosensitive sensor is disposed on a side of the component portion proximate to the mirror switching portion. The wiring portion has lines electrically connected to the first photosensitive sensor and bonding pads of the bonding portion. The driver board is electrically connected to the wiring portion of the first flexible circuit board.

Abstract: A heating module, a heat dissipation apparatus, and a communication device. The heating module includes an enclosure, a first heating component, and a floating cover. The first heating component is disposed in the enclosure, the enclosure has an opening, and the floating cover has a first boss. The first boss extends into the opening. The floating cover is mounted on the enclosure via a first elastic member, and the first elastic member drives the first boss to apply first pressure to the first heating component.

Abstract: An uplink control information transmission method includes: in a case that a PUCCH resource carrying CSI and a PUCCH resource corresponding to an SR overlap in time domain, determining a state of an SR; and in a case that at least one SR of a first priority is in a positive state, skipping transmitting the CSI, and transmitting the SR of the first priority in the positive state on a PUCCH resource corresponding to the SR of the first priority in the positive state; in a case that all SRs of a first priority are in a negative state, and SRs of a second priority exist, multiplexing and transmitting the SRs of the second priority and the CSI on the PUCCH resource of the CSI.

Abstract: The present disclosure belongs to the technical fields of nanoscience and fluorescence sensing, and specifically relates to a preparation method of a paper-based sensor for detecting an ammonia gas, and a use of the paper-based sensor. In the present disclosure, Zn(PA)(BPE) is first prepared, and a porous structure on a surface of the Zn(PA)(BPE) is used to adsorb an ammonia gas to improve a reaction sensitivity of the ammonia gas; then a Zn(PA)@CNQD ratiometric fluorescent substance is prepared from Zn(PA)(BPE) and CNQD through embedding, and finally dissolved in ultrapure water (UPW) to obtain a solution; and the solution is added dropwise on a filter paper, and the filter paper is purged with nitrogen, such that the solution is loaded on the filter paper to obtain a ratiometric fluorescent paper-based sensor.

Abstract: A circuit board module includes a substrate, an optical module component, an elastic component, and a heat sink. The optical module component includes a housing and an optical module, the housing is arranged on a side of the substrate, a hole is provided on a side that is of the housing and that is away from the substrate, and the optical module is inserted into the housing from a first end of the housing in a first direction. A first end of the elastic component is fixedly coupled to the substrate, and a second end of the elastic component is fixedly coupled to a side that is of the housing and that faces the substrate. The heat sink is arranged on a side that is of the housing and that is away from the substrate, and the heat sink is fixedly coupled to the substrate.

Abstract: Disclosed is a system and method for operating an imaging system. The imaging system may move or be moved to acquire image data of a subject at different positions relative to the subject. The image data may, thereafter, be combined to form a single image.

Abstract: A preparation method and application of spindle-shaped W@CuO material with adjustable included angle includes the steps of: preparing a copper source solution and adding to a mixture of anionic surfactant and n-butanol; adding a tungsten source solution and dripping an alkali solution, then carrying out hydrothermal reaction, centrifugation, washing and drying. By controlling the growth rate of the high-energy surface at the water-oil interface with the salt concentration, surfactant concentration, supersaturation of water and n-butanol solutions, the monodispersed spindle-shaped structure with unique microstructure and an included angle of 27-74° can be prepared. The surface of W@CuO materials with different included angles shows different electric field strengths, which can effectively modulate the charge transfer during the catalytic process and improve the catalytic reaction activity.

Abstract: A method utilizing optical path difference in two-phase flow for analytical calculation of particle size gradation and solid content comprises: changing a width of measurement area of a laser particle size analyzer, and collecting extinction values at two different optical path lengths and a scattered light intensity signal on each detector during monitoring; utilizing the scattered light intensity signal with a long optical path to subtract the scattered light intensity signal with a short optical path on each detector to obtain a set of new scattered light intensity signals with background subtracted; processing particle size distribution inversion calculations for the set of scattered light intensity signals with background subtracted to obtain gradation data of solid particles; processing subtraction of the logarithm of the extinction value of the short optical path from the logarithm of the extinction value of the long optical path to obtain new extinction value; calculating the solid content based on th

Abstract: A hybrid automatic repeat request acknowledgement (HARQ-ACK) processing method includes: selecting at least a part of HARQ-ACK bits as a first HARQ-ACK bit from a first HARQ-ACK codebook according to at least one of information indicated by DCI corresponding to the first HARQ-ACK codebook or indexes of carriers where PDSCHs corresponding to the first HARQ-ACK codebook are located, and according to at least one of a quantity of multiplexed HARQ-ACK bits or a code rate of HARQ-ACK transmission; and discarding the first HARQ-ACK bit; or determining a first HARQ-ACK bit from a first HARQ-ACK codebook according to at least one of the information indicated by the DCI or the indexes of carriers; and multiplexing the first HARQ-ACK bit and HARQ-ACK bits in a second HARQ-ACK codebook. The first HARQ-ACK bit is at least a part of HARQ-ACK bits in the first HARQ-ACK codebook.