Abstract: Antibody-drug conjugate compounds comprising a linker and methods of using such compounds are provided.

Abstract: The present disclosure provides antibody drug conjugates comprising antibodies and antigen-binding fragments thereof and a linker-payload, a pharmaceutical composition comprising the antibody drug conjugates, and use of the antibody drug conjugate for treating diseases or disorders. The antibodies or antigen-binding fragments thereof specifically bind to a first and second epitope of human cMET and to human EGFR. The diseases or disorders are EGFR/cMET-associated diseases or disorders.

Abstract: In accordance with an embodiment, a feed stripline includes: a signal input line; a first power branch line; and a second power branch line. A first end of the signal input line is configured to be conductively coupled to an external signal source, a second end of the signal input line is electrically connected to each of the first power branch line and the second power branch line, the first power branch line includes a jump structure, the first power branch line spans from a first side of the second power branch line to a second other side of the second power branch line via the jump structure, and the jump structure and the second power branch line are spaced apart from each other.

Abstract: Embodiments of this application disclose a radio frequency module. The radio frequency module provided in this application includes a power division network, a first branch circuit, and a second branch circuit. The first branch circuit includes an impedance adjustment network and a first radio frequency output port, and the second branch circuit includes a phase-shift filtering network and a second radio frequency output port. The power division network is connected to a radio frequency output end, the first branch circuit, and the second branch circuit. The impedance adjustment network is configured to adjust impedance of the first branch circuit based on power of the first branch circuit. The phase-shift filtering network is configured to control an output status of the second branch circuit and a phase of an output signal of the second branch circuit, where the output status indicates whether the second branch circuit outputs a signal.

Abstract: The present disclosure provides antibody drug conjugate platforms comprising a self-stabilizing linker assembly component, and antibody drug conjugates comprising platform-derived linker-payloads and antibodies or antigen-binding fragments thereof. In some embodiments, an antibody drug conjugate is of the following formula: or a pharmaceutically acceptable salt, tautomer, solvate, or stereoisomer thereof, wherein values for the variables (e.g., BA, RG, R1a, R1b, r, RS, R2a, R2b, s, R4, R3a, R3b, t, RE, A, a?, W, w?, Y, y?, PA, x) are as described herein.

Abstract: Embodiments of this application disclose a gating apparatus and a gating method, to implement a gating function in a simple structure and matching form. In this application, an example gating apparatus includes four main branches, M loading branches, M radio frequency switches, and four ports. The M radio frequency switches are all grounded, and M is equal to 2 or 4. The four main branches are sequentially connected end to end, and one of the four ports is disposed at a junction of any two connected main branches in the four main branches. When M is equal to 4, each of the four main branches is connected to one of the four loading branches, and each loading branch is connected to one of the M radio frequency switches.

Abstract: Provided herein are antibody drug conjugates comprising an antibody or antigen binding fragment thereof capable of specific binding to human B7H3 and a cytotoxic agent, such as an exatecan analogue. Also provided are pharmaceutical compositions comprising the antibody drug conjugates and methods of using the antibody drug conjugates, e.g., to treat a 4Ig-B7H3 positive cancer.

Abstract: Anti-FGFR2b antibodies and antigen-binding fragments thereof are provided herein, as are immunoconjugates comprising the same, and compositions comprising the antibodies and immunoconjugates. Also provided are methods of making and using the antibodies and immunoconjugates, such as to treat an FGFR2b-related disease or disorder. The antibodies of the disclosure bind to human FGFR2b and can block the interaction between the KGF ligand and FGFR2b.

Abstract: Antibody-drug conjugate compounds comprising a linker and methods of using such compounds are provided.

Abstract: The present disclosure provides antibody drug conjugates comprising antibodies and antigen-binding fragments thereof that bind to human CEA and a linker-payload, a pharmaceutical composition comprising the anti-CEA antibody drug conjugate, and use of the anti-CEA antibody drug conjugate for treating a CEA-related diseases or disorders.

Abstract: Antibody-drug conjugate compounds comprising a linker and methods of using such compounds are provided.

Abstract: Disclosed embodiments provide a feed circuit, an antenna device, a communication device, and a communication system that are configured to improve passive intermodulation (PIM). In the feed circuit, phase shift elements are disposed along a plurality of parallel branches to cancel PIM caused by semiconductor components in semiconductor modules in the branches.

Abstract: In accordance with an embodiment, a feed stripline includes: a signal input line; a first power branch line; and a second power branch line. A first end of the signal input line is configured to be conductively coupled to an external signal source, a second end of the signal input line is electrically connected to each of the first power branch line and the second power branch line, the first power branch line includes a jump structure, the first power branch line spans from a first side of the second power branch line to a second other side of the second power branch line via the jump structure, and the jump structure and the second power branch line are spaced apart from each other.

Abstract: A frame for installing an arc-shaped LED display screen composed of a plurality of LED display modules. The top partition panel and the bottom partition panel have arc edges with the same arc, and are parallel to and spaced apart from each other and both fixed to the primary support, the secondary support, the plurality of module supports, the left support, and the right support. The left support, the right support, and the plurality of module supports are equally spaced apart and fixed along the arc edge of each of the top partition panel and the bottom partition panel, and are configured to connect the plurality of LED display modules, to achieve a seamless assemblage of the arc-shaped LED display screen.

Abstract: A frame for installing an arc-shaped LED display screen composed of a plurality of LED display modules. The top partition panel and the bottom partition panel have arc edges with the same arc, and are parallel to and spaced apart from each other and both fixed to the primary support, the secondary support, the plurality of module supports, the left support, and the right support. The left support, the right support, and the plurality of module supports are equally spaced apart and fixed along the arc edge of each of the top partition panel and the bottom partition panel, and are configured to connect the plurality of LED display modules, to achieve a seamless assemblage of the arc-shaped LED display screen.

Abstract: The present application relates to a method for seamless splicing of a special-shaped display screen, including: dividing the special-shaped display screen into a number of regular quadrilateral modules and a number of special-shaped modules; calculating a number of LED light pieces on a first side of a regular quadrilateral module after division; determining the number of the LED light pieces arranged on the first side of the regular quadrilateral module; calculating a number of LED light pieces arranged on a second side of the regular quadrilateral module, and the second side is adjacent to the first side; and continuing for the number of special-shaped modules obtained above.