Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases

Abstract: The present disclosure relates to antibodies that selectively bind to CD3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: An optoelectrical assembly includes a voltage conversion circuit, an optoelectrical semiconductor device, an optoelectrical detection circuit, and a controller. The voltage conversion circuit provides a bias voltage to the optoelectrical semiconductor device, and adjusts, by changing the bias voltage, an output optical power. A differential resistance value (Rdiff) of the optoelectrical semiconductor device within a range of a target optical power satisfies 0.1 ohm (?)?Rdiff?50?, and the differential resistance value is a ratio of a voltage variation to a current variation corresponding to the voltage variation. The optoelectrical detection circuit detects the output optical power, and outputs a detection signal to the controller. The controller determines a control signal based on the detection signal, and outputs the control signal to the voltage conversion circuit, where the control signal is used to adjust the bias voltage.

Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Abstract: Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.

Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: Provided are immunoconjugates comprising bispecific anti-MUC 1/EGFR antibodies conjugated to hemiasterlin-based moieties via cleavable linkers, and pharmaceutical compositions thereof. Provided also are methods of treating cancer using such immunoconjugates and pharmaceutical compositions.

Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.

Abstract: Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.

Abstract: Various examples of simultaneous ocean wave and current energy harvesting are described, using a hybrid ocean energy converter and a mechanical transfer system therefor. In one example, a hybrid ocean energy converter includes a two-body point absorber comprising a first body and a second body. The two-body point absorber can be configured to transfer a linear relative motion between the first body and the second body to bi-directional rotation of a first input shaft. A turbine can be configured rotate a second input shaft. The converter further includes a hybrid power takeoff including a mechanical transfer system configured to mechanically couple the first input shaft, the second input shaft, an output shaft, and an output shaft.

Abstract: The present disclosure relates to antibody conjugates with binding specificity for BCMA (BCMA) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods.

Abstract: The present disclosure relates to antibody conjugates with binding specificity for BCMA (BCMA) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods.

Abstract: The present disclosure provides a method, an apparatus and a search node for warming up index files during a search service. The search service is provided by at least one search node in a search system. A first index file is stored in a disk in the search node, and a first group of pages from the first index file is stored in a cache in the search node. A second index file is stored into the disk in the search node. A plurality of queries is received during the search service. At least one warm-up query is determined from the plurality of queries. A warm-up search is performed based on the second index file in response to the at least one warm-up query. A second group of pages in the second index file is stored into the cache based on a result of the warm-up search.

Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: Provided herein are antibodies that selectively bind to CD74 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: The present disclosure relates to antibodies that selectively bind to B-cell maturation antigen (BCMA) and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: Provided herein are antibodies that selectively bind to CD74 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: The present disclosure provides a method, an apparatus and a search node for warming up index files during a search service. The search service is provided by at least one search node in a search system. A first index file is stored in a disk in the search node, and a first group of pages from the first index file is stored in a cache in the search node. A second index file is stored into the disk in the search node. A plurality of queries is received during the search service. At least one warm-up query is determined from the plurality of queries. A warm-up search is performed based on the second index file in response to the at least one warm-up query. A second group of pages in the second index file is stored into the cache based on a result of the warm-up search.