Patents by Inventor Xiaofan Li

Xiaofan Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250236674
    Abstract: Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
    Type: Application
    Filed: July 24, 2023
    Publication date: July 24, 2025
    Inventors: Ryan STAFFORD, Alice YAM, Avinash GILL, Kalyani PENTA, Xiaofan LI, Aaron SATO
  • Publication number: 20250135025
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: December 30, 2024
    Publication date: May 1, 2025
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Christina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20250122306
    Abstract: The present disclosure relates to antibodies and antibody conjugates that selectively bind to tissue factor and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies and antibody conjugates, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: October 11, 2024
    Publication date: April 17, 2025
    Inventors: Grace Jungeun LEE, Amandeep Kaur GAKHAL, Daniel CALARESE, Junhao YANG, Krishna BAJJURI, Xiaofan LI, Sihong ZHOU, Helena KIEFEL, Robert Tian-Xuan YUAN, Andrew James MCGEEHAN, Miao WEN, Gang YIN, Alice yAM
  • Publication number: 20250090676
    Abstract: The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: July 17, 2024
    Publication date: March 20, 2025
    Inventors: Ryan STAFFORD, Alice YAM, Xiaofan LI, Gang YIN, Toni KLINE, Cristina ABRAHAMS, Venita DE ALMEIDA
  • Publication number: 20250076269
    Abstract: The present invention relates to a collection method for a particulate matter detector, including: performing normalized calculation on collected initial air particulate matter values, to calculate an initial particulate matter variation among the initial air particulate matter values; obtaining a real-time collection cycle coefficient by performing calculation on the initial particulate matter variation through a stepwise approximation method and table lookup, and calculating a real-time particulate matter collection interval time; then, collecting an air particulate matter value again after the real-time collection interval time, where the air particulate matter value collected at this time is a latest air particulate matter value; performing normalized calculation on the latest air particulate matter value and a data value displayed by the particulate matter detector, to calculate a real-time particulate matter variation; and obtaining a new real-time collection cycle coefficient by performing calculation
    Type: Application
    Filed: April 4, 2024
    Publication date: March 6, 2025
    Applicant: ELITECH TECHNOLOGY, INC.
    Inventors: Zhao Gao, Ning Xue, Xiaofan Li, Tongsheng SUN
  • Patent number: 12226490
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: February 18, 2025
    Assignee: Sutro Biopharma, Inc.
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20250053824
    Abstract: Provided a method for training a multi-task fusion detection model includes: obtaining a single-task detection model of each detection task in a detection task set, and obtaining an initial multi-task fusion detection model to be trained based on each single-task detection model; obtaining a training sampling set of the initial multi-task fusion detection model by obtaining a single-task sampling data set of each detection task, in which the training sample set includes a single-task sample and a multi-task sample; and training the initial multi-task fusion detection model according to the single-task sample and/or the multi-task sample until the training is completed, to obtain a trained target multi-task fusion detection model.
    Type: Application
    Filed: October 31, 2024
    Publication date: February 13, 2025
    Applicant: BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.
    Inventors: Xiaofan Li, Ji Wan
  • Publication number: 20250018054
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: September 4, 2024
    Publication date: January 16, 2025
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Patent number: 12168968
    Abstract: Various examples of simultaneous ocean wave and current energy harvesting are described, using a hybrid ocean energy converter and a mechanical transfer system therefor. In one example, a hybrid ocean energy converter includes a two-body point absorber comprising a first body and a second body. The two-body point absorber can be configured to transfer a linear relative motion between the first body and the second body to bi-directional rotation of a first input shaft. A turbine can be configured rotate a second input shaft. The converter further includes a hybrid power takeoff including a mechanical transfer system configured to mechanically couple the first input shaft, the second input shaft, an output shaft, and an output shaft.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: December 17, 2024
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Lei Zuo, Robert Parker, Xiaofan Li
  • Publication number: 20240409630
    Abstract: The present disclosure relates to antibodies that selectively bind to folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: June 24, 2024
    Publication date: December 12, 2024
    Inventors: Ryan STAFFORD, Alice YAM, Xiaofan LI, Robert HENNINGSON, Sihong ZHOU, Heather STEPHENSON, Junhao YANG, Aaron SATO
  • Patent number: 12144869
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Grant
    Filed: June 30, 2023
    Date of Patent: November 19, 2024
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20240368295
    Abstract: The present disclosure relates to antibodies that selectively bind to B-cell maturation antigen (BCMA) and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: April 17, 2024
    Publication date: November 7, 2024
    Inventors: Alice YAM, Ryan STAFFORD, Xiaofan LI, Junhao YANG, Stephanie ARMSTRONG, Abigail YU
  • Patent number: 12071477
    Abstract: The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. The variable light chains are those of trastuzumab. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods. The antibody conjugates comprise a non-natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC-S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-S136, HC-S25, HC-A40, HC-S119, HC-S190, HC-K222, HC-R19, HC-Y52, or HC-S70, according to the Kabat, Chothia, or EU numbering scheme.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: August 27, 2024
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Ryan Stafford, Alice Yam, Xiaofan Li, Gang Yin, Toni Kline, Cristina Abrahams, Venita De Almeida
  • Publication number: 20240182580
    Abstract: Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
    Type: Application
    Filed: June 8, 2023
    Publication date: June 6, 2024
    Inventors: Ryan STAFFORD, Alice YAM, Avinash GILL, Kalyani PENTA, Xiaofan LI, Aaron SATO
  • Patent number: 11993658
    Abstract: The present disclosure relates to antibodies that selectively bind to B-cell maturation antigen (BCMA) and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 28, 2024
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Alice Yam, Ryan Stafford, Xiaofan Li, Junhao Yang, Stephanie Armstrong, Abigail Yu
  • Publication number: 20240139285
    Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases
    Type: Application
    Filed: May 30, 2023
    Publication date: May 2, 2024
    Inventors: Alice YAM, Andreas MADERNA, Cristina ABRAHAMS, Willy SOLIS, Xiaofan LI, Ryan STAFFORD, Gang YIN, Venita DE ALMEIDA, Krishna BAJJURI, Adam A. GALAN
  • Publication number: 20240124585
    Abstract: The present disclosure relates to antibodies that selectively bind to CD3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 18, 2024
    Inventors: Ryan STAFFORD, Junhao YANG, Alice YAM, Joni CASTRO, Gang YIN, Cuong TRAN, Xiaofan LI, Abigail YU
  • Publication number: 20240101631
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Application
    Filed: October 11, 2023
    Publication date: March 28, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • Publication number: 20240058465
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: June 30, 2023
    Publication date: February 22, 2024
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20240058467
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: July 10, 2023
    Publication date: February 22, 2024
    Inventors: AMANDEEP GAKHAL, ABIGAIL YU, RYAN STAFFORD, JEFFREY HANSON, ALICE YAM, KRISHNA BAJJURI, ANDREAS MADERNA, CRISTINA ABRAHAMS, XIAOFAN LI, GANG YIN, MIAO WEN, KRISTIN BEDARD, DANIEL CALARESE, HELENA KIEFEL