Patents by Inventor Xiaofang LUO
Xiaofang LUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100112Abstract: Provided are a traditional Chinese medicine ointment for preventing and treating mastitis in dairy cows and a preparation method thereof, belonging to the technical field of veterinary traditional Chinese medicines. The traditional Chinese medicine ointment includes raw materials in parts by mass: 20-30 parts of dandelion, 20-30 parts of herba patriniae, 10-16 parts of Caulis Lonicerae Japonicae, 0.5-1 part of borneol, 0.03-0.05 part of polypeptide, 40-50 parts of auxiliary emulsifier, 40-50 parts of liquid paraffin and 100-130 parts of white vaseline. An amino acid sequence of the polypeptide is: Phe Phe Arg Lys Val Leu Lys Leu Ile Arg Lys Ile Trp Arg (SEQ ID NO. 1). In the application, dandelion, herba patriniae, Caulis Lonicerae Japonicae and borneol 1 are mixed, and polypeptide is added at the same time to prepare ointment.Type: ApplicationFiled: September 14, 2023Publication date: March 28, 2024Inventors: Zongcheng WANG, Yuanfei XU, Zuodong QIN, Zhenmin CAO, Xiaofang LUO, Chen GUI, Shuwen WANG, Manting LI, Asad Nawaz
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Patent number: 11732684Abstract: A vortex-induced vibration power generation device with a magnetic boundary structure, including upper and lower opposite groups of fixed sleeves. Each fixed sleeve includes two vertical sleeves. The vertical sleeves are hollow cavities, and include sealed ends and open ends. Rotating magnetic poles are arranged in the sealed ends of the vertical sleeves. Coil slots are formed in the inner walls of the vertical sleeves. Coil windings are mounted in the coil slots. The vortex-induced vibration power generation device further includes linear bearings. The end portions of the linear bearings are fixedly connected with the open ends of the vertical sleeves through flanges. A vibration mechanism includes a vibration rod and vibration guide rods fixedly connected with the vibration rod. Magnetic coil mounting slots and anti-falling rings are arranged on the vibration guide rods. Magnetic coils are mounted in the magnetic coil mounting slots.Type: GrantFiled: December 12, 2018Date of Patent: August 22, 2023Assignee: JIANGSU UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Xu Bai, XiaoFang Luo, ZhiBin Le
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Patent number: 11590199Abstract: Disclosed herein is a use of an adenosine triphosphate (ATP) binding cassette (ABC) transporter peptide inhibitor HX-12C. This disclosure also discloses a method of treating a tumor with multidrug resistance mediated by the ABC transporter using a combination of the peptide HX-12C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug. Moreover, this disclosure also provides a composition for treating a tumor with multidrug resistance mediated by an ABC transporter, consisting of the peptide HX-12C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug.Type: GrantFiled: May 18, 2021Date of Patent: February 28, 2023Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Xiaofang Luo, Zuodong Qin, Meifeng Wang, Dongfang Tang
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Patent number: 11458188Abstract: Provided are an ABC transporter peptide inhibitor XH-14C and an application thereof in the treatment of a tumor with multidrug resistance mediated by an ABC transporter. In the application, the peptide inhibitor XH-14C shown in SEQ ID NO: 1 is administered in combination with an ABC transporter substrate chemotherapeutic drug. This disclosure also provides a pharmaceutical composition for treating a tumor with multidrug resistance mediated by the ABC transporter, containing the peptide XH-14C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug.Type: GrantFiled: May 18, 2021Date of Patent: October 4, 2022Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Zuodong Qin, Xiaofang Luo, Luya Feng, Zongcheng Wang
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Patent number: 11319339Abstract: Disclosed is a multi-channel peptide synthesizer, including a gas-bath thermotank, a plurality of reactor tubes, a motor, a rotating rack, a liquid-feeding tube, a feeding device, a vacuum tube and a nitrogen tube. The gas-bath thermotank body provides a desired constant temperature for reaction. The reactor tube provides a place for peptide synthesis and resin washing. The motor and the rotating rack are used to fully mix the reaction and cleaning solutions. Various liquid reagents required are fed to the reactor tube through the liquid-adding tube. Various materials required are prepared in advance in the feeding device and directly fed to the reactor tube. The reaction or washing solution in the reactor tube is pumped to a waste liquid tank through the vacuum tube. Nitrogen is introduced into each reactor tube through the nitrogen tube. This device can be applied in batch-wise peptide synthesis using solid-phase methods.Type: GrantFiled: June 12, 2019Date of Patent: May 3, 2022Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Xiaofang Luo, Yulu Gong, Zuodong Qin, Zongcheng Wang, Pingkai Ouyang
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Publication number: 20210332787Abstract: A vortex-induced vibration power generation device with a magnetic boundary structure, including upper and lower opposite groups of fixed sleeves. Each fixed sleeve includes two vertical sleeves. The vertical sleeves are hollow cavities, and include sealed ends and open ends. Rotating magnetic poles are arranged in the sealed ends of the vertical sleeves. Coil slots are formed in the inner walls of the vertical sleeves. Coil windings are mounted in the coil slots. The vortex-induced vibration power generation device further includes linear bearings. The end portions of the linear bearings are fixedly connected with the open ends of the vertical sleeves through flanges. A vibration mechanism includes a vibration rod and vibration guide rods fixedly connected with the vibration rod. Magnetic coil mounting slots and anti-falling rings are arranged on the vibration guide rods. Magnetic coils are mounted in the magnetic coil mounting slots.Type: ApplicationFiled: December 12, 2018Publication date: October 28, 2021Inventors: Xu Bai, XiaoFang Luo, ZhiBin Le
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Publication number: 20210315965Abstract: Provided are an ABC transporter peptide inhibitor XH-14C and an application thereof in the treatment of a tumor with multidrug resistance mediated by an ABC transporter. In the application, the peptide inhibitor XH-14C shown in SEQ ID NO: 1 is administered in combination with an ABC transporter substrate chemotherapeutic drug. This disclosure also provides a pharmaceutical composition for treating a tumor with multidrug resistance mediated by the ABC transporter, containing the peptide XH-14C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug.Type: ApplicationFiled: May 18, 2021Publication date: October 14, 2021Inventors: Zuodong QIN, Xiaofang LUO, Luya FENG, Zongcheng WANG
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Publication number: 20210275626Abstract: Disclosed herein is a use of an adenosine triphosphate (ATP) binding cassette (ABC) transporter peptide inhibitor HX-12C. This disclosure also discloses a method of treating a tumor with multidrug resistance mediated by the ABC transporter using a combination of the peptide HX-12C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug. Moreover, this disclosure also provides a composition for treating a tumor with multidrug resistance mediated by an ABC transporter, consisting of the peptide HX-12C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug.Type: ApplicationFiled: May 18, 2021Publication date: September 9, 2021Inventors: Xiaofang LUO, Zuodong QIN, Meifeng WANG, Dongfang TANG
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Patent number: 10918692Abstract: Disclosed are antimicrobial peptides capable of inhibiting and killing multiple drug-resistant bacteria, including XH-12C, XH-12B and XH-12A. The application further provides uses of the antimicrobial peptides in the preparation of a drug for inhibiting and/or killing fungi, Gram-positive bacteria, Gram-negative bacteria and drug-resistant bacteria and in the manufacture of medical carriers.Type: GrantFiled: February 13, 2020Date of Patent: February 16, 2021Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Xiaofang Luo, Zuodong Qin, Fulin He, Xiaoping Ouyang, Zhizhang Li, Changjian Li, Qianrui Peng, Zhesheng Chen
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Patent number: 10898541Abstract: Disclosed are antimicrobial peptides capable of inhibiting and killing multiple drug-resistant bacteria, including XH-12C, XH-12B and XH-12A. The application further provides uses of the antimicrobial peptides in the preparation of a drug for inhibiting and/or killing fungi, Gram-positive bacteria, Gram-negative bacteria and drug-resistant bacteria and in the manufacture of medical carriers.Type: GrantFiled: February 13, 2020Date of Patent: January 26, 2021Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Xiaofang Luo, Zuodong Qin, Fulin He, Xiaoping Ouyang, Zhizhang Li, Changjian Li, Qianrui Peng, Zhesheng Chen
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Publication number: 20200197478Abstract: Disclosed are antimicrobial peptides capable of inhibiting and killing multiple drug-resistant bacteria, including XH-12C, XH-12B and XH-12A. The application further provides uses of the antimicrobial peptides in the preparation of a drug for inhibiting and/or killing fungi, Gram-positive bacteria, Gram-negative bacteria and drug-resistant bacteria and in the manufacture of medical carriers.Type: ApplicationFiled: February 13, 2020Publication date: June 25, 2020Inventors: Xiaofang LUO, Zuodong QIN, Fulin HE, Xiaoping OUYANG, Zhizhang LI, Changjian LI, Qianrui PENG, Zhesheng CHEN
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Publication number: 20200197479Abstract: Disclosed are antimicrobial peptides capable of inhibiting and killing multiple drug-resistant bacteria, including XH-12C, XH-12B and XH-12A. The application further provides uses of the antimicrobial peptides in the preparation of a drug for inhibiting and/or killing fungi, Gram-positive bacteria, Gram-negative bacteria and drug-resistant bacteria and in the manufacture of medical carriers.Type: ApplicationFiled: February 13, 2020Publication date: June 25, 2020Inventors: Xiaofang LUO, Zuodong QIN, Fulin HE, Xiaoping OUYANG, Zhizhang LI, Changjian LI, Qianrui PENG, Zhesheng CHEN
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Patent number: 10603350Abstract: Disclosed are antimicrobial peptides capable of inhibiting and killing multiple drug-resistant bacteria, including XH-12C, XH-12B and XH-12A. The application further provides uses of the antimicrobial peptides in the preparation of a drug for inhibiting and/or killing fungi, Gram-positive bacteria, Gram-negative bacteria and drug-resistant bacteria and in the manufacture of medical carriers.Type: GrantFiled: May 8, 2019Date of Patent: March 31, 2020Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Xiaofang Luo, Zuodong Qin, Fulin He, Xiaoping Ouyang, Zhizhang Li, Changjian Li, Qianrui Peng, Zhesheng Chen
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Publication number: 20200048302Abstract: Disclosed is a multi-channel peptide synthesizer, including a gas-bath thermotank, a plurality of reactor tubes, a motor, a rotating rack, a liquid-feeding tube, a feeding device, a vacuum tube and a nitrogen tube. The gas-bath thermotank body provides a desired constant temperature for reaction. The reactor tube provides a place for peptide synthesis and resin washing. The motor and the rotating rack are used to fully mix the reaction and cleaning solutions. Various liquid reagents required are fed to the reactor tube through the liquid-adding tube. Various materials required are prepared in advance in the feeding device and directly fed to the reactor tube. The reaction or washing solution in the reactor tube is pumped to a waste liquid tank through the vacuum tube. Nitrogen is introduced into each reactor tube through the nitrogen tube. This device can be applied in batch-wise peptide synthesis using solid-phase methods.Type: ApplicationFiled: June 12, 2019Publication date: February 13, 2020Inventors: Xiaofang LUO, Yulu GONG, Zuodong QIN, Zongcheng WANG, Pingkai OUYANG
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Publication number: 20190336568Abstract: Disclosed are antimicrobial peptides capable of inhibiting and killing multiple drug-resistant bacteria, including XH-12C, XH-12B and XH-12A. The application further provides uses of the antimicrobial peptides in the preparation of a drug for inhibiting and/or killing fungi, Gram-positive bacteria, Gram-negative bacteria and drug-resistant bacteria and in the manufacture of medical carriers.Type: ApplicationFiled: May 8, 2019Publication date: November 7, 2019Inventors: Xiaofang LUO, Zuodong QIN, Fulin HE, Xiaoping OUYANG, Zhizhang LI, Changjian LI, Qianrui PENG, Zhesheng CHEN