Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: Various embodiments include a modulo operation generator associated with a cache memory in a computer-based system. The modulo operation generator generates a first sum by performing an addition and/or a subtraction function on an input address. A first portion of the first sum is applied to a lookup table that generates a correction value. The correction value is then added to a second portion of the first sum to generate a second sum. The second sum is adjusted, as needed, to be less than the divisor. The adjusted second sum forms a residue value that identifies a cache memory slice in which the input data value corresponding to the input address is stored. By generating the residue value in this manner, the cache memory efficiently distributes input data values among the slices in a cache memory even when the number of slices is not a power of two.

Abstract: Various embodiments include a modulo operation generator associated with a cache memory in a computer-based system. The modulo operation generator generates a first sum by performing an addition and/or a subtraction function on an input address. A first portion of the first sum is applied to a lookup table that generates a correction value. The correction value is then added to a second portion of the first sum to generate a second sum. The second sum is adjusted, as needed, to be less than the divisor. The adjusted second sum forms a residue value that identifies a cache memory slice in which the input data value corresponding to the input address is stored. By generating the residue value in this manner, the cache memory efficiently distributes input data values among the slices in a cache memory even when the number of slices is not a power of two.

Abstract: Various embodiments include a modulo operation generator associated with a cache memory in a computer-based system. The modulo operation generator generates a first sum by performing an addition and/or a subtraction function on an input address. A first portion of the first sum is applied to a lookup table that generates a correction value. The correction value is then added to a second portion of the first sum to generate a second sum. The second sum is adjusted, as needed, to be less than the divisor. The adjusted second sum forms a residue value that identifies a cache memory slice in which the input data value corresponding to the input address is stored. By generating the residue value in this manner, the cache memory distributes input data values among the slices in a cache memory even when the number of slices is not a power of two.

Abstract: Various embodiments include a modulo operation generator associated with a cache memory in a computer-based system. The modulo operation generator generates a first sum by performing an addition and/or a subtraction function on an input address. A first portion of the first sum is applied to a lookup table that generates a correction value. The correction value is then added to a second portion of the first sum to generate a second sum. The second sum is adjusted, as needed, to be less than the divisor. The adjusted second sum forms a residue value that identifies a cache memory slice in which the input data value corresponding to the input address is stored. By generating the residue value in this manner, the cache memory efficiently distributes input data values among the slices in a cache memory even when the number of slices is not a power of two.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.

Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.

Abstract: We identify markers capable of guiding the decision to incorporate epidermal growth factor receptor (EGFR) inhibitors, in particular EGFR tyrosine kinase inhibitors (TKIs), into chemotherapeutic regimens. Mitogen-inducible gene 6 (Mig6), a negative regulator of EGFR, is selectively upregulated during the development of resistance to the EGFR tyrosine kinase inhibitor (TKI) erlotinib, resulting in decreased EGFR phosphorylation. The ratio of Mig6/EGFR expression highly correlates with erlotinib sensitivity. A low Mig6/EGFR ratio correlates with a high response rate to gefitinib and a marked increase in progression-free survival for patients. The ratio of Mig6 to EGFR is a major predictor of biologic and clinical responses to EGFR inhibitors.

Abstract: The invention provides antiangiogenic compositions and methods of use. The general methods deliver an antiangiogen to a patient determined to be in need thereof, comprising the steps of: (a) administering to the patient a predetermined amount of an antiangiogenic, optionally substituted DIM; and (b) detecting in the patient a resultant antiangiogenic response.