Abstract: A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.

Abstract: The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4 growth factors.

Abstract: The invention relates to truncated BMP-7 growth factors and variants thereof. The invention also relate to methods of making and using the truncated BMP-7 growth factors.

Abstract: A pushing and jam-releasing pup joint of a formation tester comprises a first jam-releasing arm (1), a first three-way reversing valve (V1), a two-way reversing valve (V2) and a third three-way reversing valve (V4), a withdrawal cavity (Q11) of the first jam-releasing arm (1) is connected with the first three-way reversing valve (V1) which can communicate with an energy accumulation cavity (NQ) of an energy accumulator and the two-way reversing valve (V2), the two-way reversing valve (V2) can be communicated with a pressure oil main line (G2) of a hydraulic system, and an extension cavity (Q12) of the first jam-releasing arm (1) is connected with the third three-way reversing valve (V4) which can communicate with the pressure oil main line (G2) and a return oil main line (G1) of hydraulic system. Jam-releasing pup joint effectively solves the problem of jam release when mud adheres to EFDT and makes same jammed.

Abstract: The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4 growth factors.

Abstract: A shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. Also, a process for repairing a cartilage defect with the cartilage matrix. The matrix is in the form of an osteochondral plug including a cartilage cap ad subchondral bone, wherein one or more gaps, slats, bores, or channels extend through the tidemark at the interface between the cartilage cap and the subchondral bone.

Abstract: The invention relates to truncated BMP-7 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-7 growth factors.

Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.

Abstract: The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation.

Abstract: The present invention is directed to a device for the growth of new bone or bone-like tissue under in vitro cell culture conditions.

Abstract: A pushing and jam-releasing pup joint of a formation tester comprises a first jam-releasing arm (1), a first three-way reversing valve (V1), a two-way reversing valve (V2) and a third three-way reversing valve (V4), a withdrawal cavity (Q11) of the first jam-releasing arm (1) is connected with the first three-way reversing valve (V1) which can communicate with an energy accumulation cavity (NQ) of an energy accumulator and the two-way reversing valve (V2), the two-way reversing valve (V2) can be communicated with a pressure oil main line (G2) of a hydraulic system, and an extension cavity (Q12) of the first jam-releasing arm (1) is connected with the third three-way reversing valve (V4) which can communicate with the pressure oil main line (G2) and a return oil main line (G1) of hydraulic system. Jam-releasing pup joint effectively solves the problem of jam release when mud adheres to EFDT and makes same jammed.

Abstract: The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps.

Abstract: The present invention is directed to a device for the growth of new bone or bone-like tissue under in vitro cell culture conditions.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.

Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relate to methods of making and using the truncated growth factors.