Abstract: The present invention relates to the technical field of network service, and in particular, to a user state switching method, a system, a device, a medium and a computer program product. The user state switching method comprises: a receiving step: receiving a switching request for a user state; a query step: querying the user state; a determination step: determining, on the basis of a finite state machine of the user state, whether to allow switching of the user state; an error return step: if the switching of the user state is not allowed, returning error information; a state switching step: if the switching of the user state is allowed, modifying and storing information of the user state, and switching the user state on the basis of the finite state machine. Can meet complex user state switching design requirements, can perform self-repair of user state abnormalities, and can push the user's state to other users in real time.

Abstract: Provided is a set of viral vectors, comprising: a first viral vector that carries a first nucleic acid molecule encoding an envelope protein, and a second viral vector that carries a second nucleic acid molecule encoding a fusion protein, the fusion protein comprising: a single-chain antibody capable of binding to CD28 or CD3, and a C-terminal domain, comprising a transmembrane region and an intracellular region, of the envelope protein. The C terminal of the single-chain antibody is connected to the N terminal of the C-terminal domain of the envelope protein, and the envelope protein and the fusion protein are in a non-fusion form. Also provided are a method for obtaining a lentivirus and an obtained lentivirus, a method for introducing a lentivirus into an unactivated T lymphocyte, a method for expressing a target gene, a method for obtaining a CAR-T cell and an obtained CAR-T cell, a pharmaceutical composition, and a use thereof.

Abstract: Provided is a fusion protein containing GLP-1 and FGF21 linked through an immunoglobulin Fc portion. Each of the GLP-1 and FGF21 can be substituted with its analogues or variants and, the Fc portion, which can be derived from IgG4, can include substitutions that further enhance the fusion protein's stability and activity. These fragments can be linked together through peptide linkers. The fusion protein can be used clinically to reduce glucose and lipid levels and body weight.

Abstract: Methods for processing deposited metal nanowire inks with metal ions are used to form fused metal nanostructured networks. The metal nanowire inks include a hydrophilic polymer binder, such as a cellulose based binder. The metal nanowire inks can be deposited onto a substrate surface and dried to drive the fusing process. Transparent conductive films can be formed with desirable properties.

Abstract: A fusion protein comprises an Fc variant and a GDF15 active domain, wherein the Fc variant has amino acid substitutions at position 356 and/or position 439 of the IgG Fc according to EU numbering and still has the ability to form homodimer. By fusing the Fc variant with the GDF15 active domain, the Fc-GDF15 fusion protein has significantly improved physicochemical properties and recombinant expression levels, has in vitro activity equivalent to or better than natural GDF15 molecules, and has significantly prolonged in vivo circulating half-life, which can support the dosing frequency of once every two weeks or even once a month.

Abstract: Provided is a fusion protein containing GLP-1 and FGF21 linked through an immunoglobulin Fc portion. Each of the GLP-1 and FGF21 can be substituted with its analogues or variants and, the Fc portion, which can be derived from IgG4, can include substitutions that further enhance the fusion protein's stability and activity. These fragments can be linked together through peptide linkers. The fusion protein can be used clinically to reduce glucose and lipid levels and body weight.

Abstract: A GDF15 fusion protein and a method for treating obesity using same. The fusion protein includes an Fc variant and a GDF15 active domain, wherein the Fc variant has an amino acid substitution at position 356 and/or position 439 of the IgG Fc according to EU numbering and still has the ability to form a homodimer. By means of fusing the Fc variant with the GDF15 active domain, the Fc-GDF15 fusion protein has significantly improved physical and chemical properties and recombinant expression level, has an in vitro activity comparable to or better than that of a natural GDF15 molecule, and has a significantly prolonged in vivo cyclic half-life, which may support the dosing frequency once every two weeks or even once a month.

Abstract: This application provides a method for processing data in a virtual scene performed by an electronic device. The method includes: receiving an instruction for editing a three-dimensional model of a virtual object controlled by a target user in the virtual scene; in response to the instruction, displaying an editing interface configured for editing the three-dimensional model of the virtual object, the three-dimensional model comprising a character model having an appearance of the virtual object and at least one information component carrying object information of the virtual object; and constructing a target three-dimensional model of the virtual object on the editing interface in accordance with subsequent instruction from the target user.

Abstract: GDF15 fusion proteins and uses thereof, the fusion protein includes an Fc variant and a GDF15 active domain, wherein the Fc variant has amino acid substitutions at position 356 and/or position 439 of the IgG Fc according to EU numbering and still has the ability to form homodimer. By fusing the Fc variant with the GDF15 active domain, the Fc-GDF15 fusion protein has significantly improved physicochemical properties and recombinant expression levels, has in vitro activity equivalent to or better than natural GDF15 molecules, and has significantly prolonged in vivo circulating half-life, which can support the dosing frequency of once every two weeks or even once a month.

Abstract: This application provides a method for processing data in a virtual scene performed by an electronic device. The method includes: displaying a plurality of projected avatars, each avatar corresponding to a respective one of a plurality of virtual objects in the virtual scene; detecting, among the plurality of virtual objects, a transformation of a first virtual object from a first avatar to a second avatar; and updating a first projected avatar corresponding to the first avatar to a second projected avatar corresponding to the second avatar in response to the transformation.

Abstract: The present disclosure discloses a virtual object display method performed by a computer device. The method includes: determining an interception plane of a three-dimensional model of a first virtual object; acquiring posture information of the three-dimensional model once after a preset time period; intercepting the three-dimensional model by using the interception plane based on the posture information to obtain an interception result, wherein the interception result comprises a partial model of the three-dimensional model located on a first side of the interception plane; and displaying the partial model on the first side. According to the technical solution provided in embodiments of this application, the model part on the first side corresponding to the three-dimensional model is displayed, so that efficiency of acquiring model information and interface utilization can be improved.

Abstract: A method for information display includes displaying, during a process of a current game task that includes a first virtual character, the first virtual character and a virtual interactive prop in the current game task. The method also includes, when a projection display operation is performed on the virtual interactive prop, displaying a virtual projection associated with a second virtual character that is included in the current game task and satisfies a projection condition. The virtual projection includes at least one of a character model projection of the second virtual character and a game data projection of the second virtual character. Apparatus and non-transitory computer-readable storage medium counterpart embodiments are also contemplated.

Abstract: This application discloses an information processing method performed by an electronic device. The method includes: obtaining a current location of a first virtual character in a scene of a virtual game while the first virtual character participates in a current game task of the virtual game under control by a client; determining that the current location matches a virtual vehicle provided by the current game task; and displaying a virtual projection corresponding to a second virtual character that meets a projection condition among virtual characters participating in the virtual game. This application resolves a technical problem of low information display efficiency.

Abstract: A light-emitting diode (LED) chip includes at least one LED. The LED includes an epitaxial structure. The epitaxial structure includes an N-type semiconductor stacked layer, a light-emitting layer, and a P-type semiconductor layer which are stacked sequentially. The N-type semiconductor stacked layer includes a first N-type semiconductor layer, an intrinsic semiconductor layer, and a second N-type semiconductor layer which are stacked sequentially. The first N-type semiconductor layer is disposed on one side of the second N-type semiconductor layer away from the light-emitting layer. The first N-type semiconductor layer includes an N-type semiconductor substrate defining holes and scattering particles filled in the holes.

Abstract: A transparent structure comprising a transparent substrate, a transparent resistive heating element mounted on the substrate, metal traces forming electrodes arranged to be in electrical contact with the transparent heating element and positioned around boundaries of a heated region defining a circuit for electrical flow through the transparent resistive heating element, and a power source connected to the electrodes with the capability of delivering at least 1 volts to the electrodes wherein the transparent resistive heating element comprises a sparse metal conductive layer comprising nanowire segments of noble metal coated silver having a sheet resistance from about 1 Ohms/sq. to about 300 Ohms/sq and having an unpatterned area of at least about 0.25 cm2.

Abstract: A method of treating fatty liver-related diseases in a patient includes administering to the patient a therapeutically effective amount of medicament manufactured from a FGF21 polypeptide, FGF21 fusion protein, or dual-fusion protein of FGF21 polypeptide and GLP-1 or a functional variant thereof.

Abstract: A group of viral vectors including: first viral vector, wherein first viral vector carries first nucleic acid molecule, and the first nucleic acid molecule encodes envelope protein; second viral vector, wherein second viral vector carries second nucleic acid molecule, the second nucleic acid molecule encodes fusion protein, the fusion protein includes single-chain antibody and C-terminal domain of envelope protein, the C-terminal domain of envelope protein includes transmembrane region and intracellular region of envelope protein, the C-terminus of single-chain antibody connects with N-terminus of C-terminal domain of envelope protein, the single-chain antibody targets a specific antigen; first nucleic acid molecule and second nucleic acid molecule are arranged to express envelope protein and fusion protein, and the envelope protein and the fusion protein are in non-fusion form.

Abstract: Structures are described having thin flexible polymer substrates with electrically conductive films on each opposing surface while having high optical transmittance and good optical properties. The structures can have total thicknesses of no more than about 30 microns and good flexibility. Processing approaches are described that allow for the coating of the very thin structures by providing support through the coating process. The structures are demonstrated to have good durability under conditions designed to test accelerated wear for touch sensor use.

Abstract: Fusing nanowire inks are described that can also comprise a hydrophilic polymer binder, such as a cellulose based binder. The fusing nanowire inks can be deposited onto a substrate surface and dried to drive the fusing process. Transparent conductive films can be formed with desirable properties.

Abstract: This application provides a method for controlling a virtual object in a virtual scene performed by an electronic device. The method includes: presenting, in the virtual scene, a first virtual object and at least one second virtual object that is in an action execution state of a target performance, wherein the action execution state of the target performance indicates that the second virtual object performs an action of the target performance in the virtual scene; in response to a movement control instruction for the first virtual object, controlling the first virtual object to move in the virtual scene; and during movement of the first virtual object, when a position of the first virtual object meets an execution condition of the target performance, controlling the first virtual object to automatically perform the action of the target performance.