Abstract: Coal rock three-dimensional strain field visual system and method are provided under mining influence. The system includes a stress condition simulation system and a strain monitoring system. The stress condition simulation system includes a similar simulation experiment rack, a loading system and a circular slideway. The method includes preparing a 3D printing wire, printing a strain visual similar model, simulating a stratum dip angle and a gas-containing condition, applying stress fields, recording a cracking and dyeing condition of microcapsules inside the model, and the like. The system can realize tracing the generation and development of internal cracks in simulation models with complex geological conditions, and tracing the three-dimensional movement of internal ink dots to draw four-dimensional images of displacement fields.

Abstract: The present invention relates to a novel lateral flow assay method and devices using a container separate from the strip to contain the dried nanoparticle conjugate. The method and devices can significantly improve the sensitivity of the lateral flow assay. It can be used in both sandwich and competitive immunoassays or non-immunological assays in the lateral flow format. In specific embodiments, the methods and devices are advantageous for identifying fentanyl and analogs in a sample.

Abstract: An oxygen reduction device in an ion source region of inductively coupled plasma is provided. The oxygen reduction device includes a torch and an inflation sleeve. An upper end of the inflation sleeve is sealed and sleeved outside the torch, and a lower end of the inflation sleeve and the torch are arranged at an interval to form an inflation gap. An inflation hole communicating with the inflation gap is formed in an outer side wall of the inflation sleeve. An outer side face of the lower end of the inflation sleeve is protruded outwards to form an annular gas guiding protrusion. The annular gas guiding protrusion is configured for being arranged opposite to a sampling cone base arranged below the torch, and a gas outlet gap is formed between the annular gas guiding protrusion and the sampling cone base.

Abstract: The present disclosure provides a CMOS image sensor and a pixel structure thereof, and a method for manufacturing a deep trench isolation grid structure in the pixel structure. The method for manufacturing the deep trench isolation grid structure comprises: depositing a first isolation layer and a second isolation layer sequentially on the side walls and bottom surface of each deep trench; and depositing a third isolation layer that fills each deep trench on the upper surface of the second isolation layer, so that the first isolation layer, the second isolation layer and the third isolation layer in the plurality of deep trenches constitute the grid. The deep trench isolation grid structure formed by the method can effectively reduce electrical crosstalk between adjacent grid lines, thereby improving the device performance of the CMOS image sensor which is built upon the deep trench isolation grid structure and the pixel structure thereof.

Abstract: The present invention relates to reporter protein fusion antibodies, transgenic animals expressing the same, and methods of using the reporter protein fusion antibodies.

Abstract: The present invention relates to reporter protein fusion antibodies, transgenic animals expressing the same, and methods of using the reporter protein fusion antibodies.

Abstract: An oxygen reduction device in an ion source region of inductively coupled plasma is provided. The oxygen reduction device includes a torch and an inflation sleeve. An upper end of the inflation sleeve is sealed and sleeved outside the torch, and a lower end of the inflation sleeve and the torch are arranged at an interval to form an inflation gap. An inflation hole communicating with the inflation gap is formed in an outer side wall of the inflation sleeve. An outer side face of the lower end of the inflation sleeve is protruded outwards to form an annular gas guiding protrusion. The annular gas guiding protrusion is configured for being arranged opposite to a sampling cone base arranged below the torch, and a gas outlet gap is formed between the annular gas guiding protrusion and the sampling cone base.

Abstract: The present disclosure provides a CMOS image sensor and a pixel structure thereof, and a method for manufacturing a deep trench isolation grid structure in the pixel structure. The method for manufacturing the deep trench isolation grid structure comprises: depositing a first isolation layer and a second isolation layer sequentially on the side walls and bottom surface of each deep trench; and depositing a third isolation layer that fills each deep trench on the upper surface of the second isolation layer, so that the first isolation layer, the second isolation layer and the third isolation layer in the plurality of deep trenches constitute the grid. The deep trench isolation grid structure formed by the method can effectively reduce electrical crosstalk between adjacent grid lines, thereby improving the device performance of the CMOS image sensor which is built upon the deep trench isolation grid structure and the pixel structure thereof.

Abstract: Coal rock three-dimensional strain field visual system and method are provided under mining influence. The system includes a stress condition simulation system and a strain monitoring system. The stress condition simulation system includes a similar simulation experiment rack, a loading system and a circular slideway. The method includes preparing a 3D printing wire, printing a strain visual similar model, simulating a stratum dip angle and a gas-containing condition, applying stress fields, recording a cracking and dyeing condition of microcapsules inside the model, and the like. The system can realize tracing the generation and development of internal cracks in simulation models with complex geological conditions, and tracing the three-dimensional movement of internal ink dots to draw four-dimensional images of displacement fields.

Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of ?-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(?-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of ?-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(?-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

Abstract: The present disclosure relates to compounds that are useful as tau phosphorylation inhibitors. Further disclosed are compounds and methods for treating or preventing Alzheimer's disease.

Abstract: The present invention relates to reporter protein fusion antibodies, transgenic animals expressing the same, and methods of using the reporter protein fusion antibodies.

Abstract: This document provides methods and materials related to self-masking tandem antibodies, for example, Self-Masking Anti-tumoR Tandem antibody (SMART-body). For instance, a self-masking tandem antibody may contain two antibody-based domains (each of which contains an antigen-binding site) that are connected by a linker peptide cleavable by a protease, and the connection between the two antibody-based domains results in the masking of at least one of the antigen-binding sites. In some embodiments, for example, the SMART-body is first provided as a single molecule which does not bind antigens because of the masking of the antigen-binding sites within the molecule, but subsequently, the linker peptide is cleaved by a protease expressed in a tumor microenvironment, severing the connection between and removing the masking of the two antibody-based domains, which can then bind antigens expressed in the tumor, achieving localized, targeted cancer therapy.