Abstract: The present disclosure provides an inhibitor, represented by formula I, of interaction between YAP/TAZ and TEAD, preparation thereof, a pharmaceutical composition thereof and use thereof. The compound provided in the present disclosure can be used as an inhibitor of interaction between YAP/TAZ and TEAD, and is used for treating or preventing diseases mediated by interaction between YAP/TAZ and TEAD.

Abstract: Provided are bicyclic heteroaryl compounds of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating cancer and other diseases.

Abstract: The present application discloses an injection system for a die casting machine, which includes an accumulator, an injection cylinder, a pressurization cylinder and a valve module connected via an oil pipeline; in a slow injection phase of the injection cylinder, the valve module is adapted for dynamic switching between a phase of an oil pump of the oil pipeline supplying oil alone and a phase of the oil pump and the accumulator jointly supplying oil; in a fast injection phase, a braking phase, a tracking phase and a pressurization injection phase, the oil pump of the oil pipeline and an oil tank form a first A-type half-bridge structure.

Abstract: Disclosed are an acylphosphine oxide compound and a preparation method therefor, which belong to the field of initiators. The method comprises: reacting compound B and compound C under the conditions of an organic base and an organic solvent so as to obtain the acylphosphine oxide compound. The chemical structural formula of compound B is as follows: the chemical structural formula of compound C is as follows: and the chemical structural formula of the acyl phosphine oxide compound is as follows: wherein R1 is hydrogen, a C1-C6 alkyl group, methoxy, methylthio, dimethylamino, chloroformyl, phenyl, benzoyl, (4-dimethylamino) phenyl, ?-naphthyl, ?-naphthyl or (9-ethyl-9H-carbazole)-3-yl, R2 and R1 are the same, n is the substitution number of R1 on the corresponding phenyl ring, and is 1, 2 or 3, and m is the substitution number of R2 on the corresponding phenyl ring, and is 1, 2 or 3. The preparation method is safe and environmentally friendly, and has a high yield.

Abstract: The disclosure is generally directed to methods and compositions for modulating keratinocyte function, more particularly, to compositions and methods for normalizing keratinocyte proliferation and differentiation, compositions and methods for modulating levels of phosphatidylglycerol (PG) in keratinocytes, and compositions and methods for treating skin conditions by modulating keratinocyte proliferation.

Abstract: The disclosure is generally directed to methods and compositions for modulating keratinocyte function, more particularly, to compositions and methods for normalizing keratinocyte proliferation and differentiation, compositions and methods for modulating levels of phosphatidylglycerol (PG) in keratinocyes, and compositions and methods for treating skin conditions by modulating keratinocyte proliferation.