Patents by Inventor Xiaoge Guo

Xiaoge Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Library-scale engineering of metabolic pathways
    Patent number: 11939571
    Abstract: Expressing guide nucleic acids (e.g., gRNA) from the same oligonucleotide that contains donor sequence permits the high efficiency, simultaneous transformation of a population of cells with both substrates. Using oligonucleotide chip array technology, one can construct thousands of oligonucleotides with customized gRNA and donor sequence in a cost effective manner. In combination, one can efficiently modify endogenous and exogenous genes.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: March 26, 2024
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Xiaoge Guo, Alejandro Chavez, Max Schubert, Eric Kelsic
  • Library-scale Engineering of Metabolic Pathways
    Publication number: 20190264196
    Abstract: Expressing guide nucleic acids (e.g., gRNA) from the same oligonucleotide that contains donor sequence permits the high efficiency, simultaneous transformation of a population of cells with both substrates. Using oligonucleotide chip array technology, one can construct thousands of oligonucleotides with customized gRNA and donor sequence in a cost effective manner. In combination, one can efficiently modify endogenous and exogenous genes.
    Type: Application
    Filed: June 12, 2017
    Publication date: August 29, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaoge Guo, Alejandro Chavez, Max Schubert, Eric Kelsic