Patents by Inventor Xiaogian Liu

Xiaogian Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic assay for Alzheimer's disease
    Patent number: 9678086
    Abstract: The present invention relates to the field of Alzheimer's disease (AD). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing AD. In another embodiment, a method for diagnosing Alzheimer's Disease (AD) in a patient comprises the steps of (a) obtaining CSF sample from the patient; (b) adding to the sample isotopically labeled peptides identical to a portion of one or more biomarker proteins, wherein the one or more biomarker proteins comprise total APP, APP isoform 751, APP isoform 770, amyloid beta 40 peptide, APOE, and Clusterin; and (c) measuring the one or more biomarker proteins in the sample using mass spectrometry, wherein the level of one or more biomarker proteins compared to a control correlates with AD in the patient.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: June 13, 2017
    Assignee: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Xiaogian Liu, Richard O'Brien
  • DIAGNOSTIC ASSAY FOR ALZHEIMER'S DISEASE
    Publication number: 20150212098
    Abstract: The present invention relates to the field of Alzheimer's disease (AD). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing AD. In another embodiment, a method for diagnosing Alzheimer's Disease (AD) in a patient comprises the steps of (a) obtaining CSF sample from the patient; (b) adding to the sample isotopically labeled peptides identical to a portion of one or more biomarker proteins, wherein the one or more biomarker proteins comprise total APP, APP isoform 751, APP isoform 770, amyloid beta 40 peptide, APOE, and Clusterin; and (c) measuring the one or more biomarker proteins in the sample using mass spectrometry, wherein the level of one or more biomarker proteins compared to a control correlates with AD in the patient.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 30, 2015
    Inventors: Jennifer Van Eyk, Xiaogian Liu, Richard O'Brien