Abstract: Provided are a 2-(aryl-2-yl) morpholine and a deuterated derivative thereof, a preparation method therefor and an application thereof. In particular, involved are the use of a compound shown by general formula (V) in the treatment of central nervous system diseases, a deuterated compound thereof, a preparation method of deuterated compound, a pharmaceutical composition containing the deuterated compound, and the use thereof as a TAAR1 agonist in the treatment of central nervous system diseases.

Abstract: Provided are a polycyclic derivative regulator, a preparation method therefor, and an application thereof. In particular, provided are a compound represented by general formula (I?), a preparation method therefor, a pharmaceutical composition comprising the compound, and an application thereof as a regulator in the preparation of a drug for treating metabolic diseases and related diseases; the substituents in general formula (I?) are the same as those defined in the description.

Abstract: Disclosed is a method for preparing a C-nucleoside compound represented by Formula (III) or salt thereof. The present method has a high reaction yield, is simple to operate, uses a single metal reagent, has stable reaction temperature conditions, does not require frequent changes to the reaction system during the operation process, is suitable for scale-up synthesis, is suitable for large-scale production of Remdesivir, and has low costs.

Abstract: Polyamide compositions for use in forming wire or cable jacket compositions. The polyamide compositions include a component of polyamide 6/66 copolymer formed from substantially randomly distributed caprolactam monomers and hexamethylenediamine monomers. The polyamide 6/66 copolymer component may form the entirety of the polyamide composition or alternatively, the polyamide composition may include an amount of polyamide 6 homopolymer blended with the polyamide 6/66 copolymer component. The composition also includes one or more additives, such as at least one UV mitigation component, and the polyamide composition further has at least one of a measured transmittance of at least 70% and a measured haze of less than 60%, as determined by ASTM D1003.

Abstract: Polyamide compositions for use in forming wire or cable jacket compositions. The polyamide compositions include a component of polyamide 6/66 copolymer formed from substantially randomly distributed caprolactam monomers and hexamethylene diamine monomers. The polyamide 6/66 copolymer component may form the entirety of the polyamide composition or alternatively, the polyamide composition may include an amount of polyamide 6 homopolymer blended with the polyamide 6/66 copolymer component. The composition also includes one or more additives, such as at least one UV mitigation component which, due to the reduced crystallinity of the polyamide 6/66 copolymer component, is incorporated into the polyamide composition with desirable transmission and haze characteristics as well as providing for retention of physical properties such as tensile strength at break and elongation at break.