Patents by Inventor Xiaohe Zheng
Xiaohe Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240287044Abstract: The present invention relates to a mesylate or ethanesulfonate salt of the compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the salt, and an application of the salt.Type: ApplicationFiled: June 1, 2022Publication date: August 29, 2024Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Jinqing ZHONG, Xinlong ZHANG, Yongxiang GONG, Lei CHEN, Xiaohe ZHENG, Lifei MAO, Yi LI
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Patent number: 10548933Abstract: Provided is a method for preparing a broccoli protein peptide. The method uses a broccoli protein as the raw material, and obtains a broccoli protein peptide powder through the steps of preprocessing, enzymatic hydrolysis, terminating enzymatic hydrolysis, separation, and drying and the like. Also provided is the use of the prepared broccoli protein peptide in resisting oxidation, reducing cholesterol and lowering blood lipids.Type: GrantFiled: May 3, 2016Date of Patent: February 4, 2020Assignees: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD., ZHEJIANG TELEY BIOTECHNOLOGY CO., LTD.Inventors: Jidong Wang, Huan Qi, Xiaohe Zheng, Hui Zhang, Yongdong Wang, Hailing Tang, Haiming Lin
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Patent number: 10442835Abstract: The present invention relates to technical fields of organic chemistry and pharmaceutical chemistry, specifically to water-soluble rapamycin derivatives modified with glutathione. More specifically, the present invention discloses a compound of formula I and the preparation method thereof, wherein R1 and R2 are as defined in the description. The compound of formula I can be used in inducing immunosuppression and in the treatment of diseases such as transplant rejection and solid tumor, etc.Type: GrantFiled: November 9, 2016Date of Patent: October 15, 2019Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Haibo Wang, Hongfu Kuang, Wei Zhang, Zhengjiang Cai, Tianmin Zhu, Xiaohe Zheng, Zhongwei Wu, Zhiqing Yang
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Publication number: 20190055284Abstract: The present invention relates to technical fields of organic chemistry and pharmaceutical chemistry, specifically to water-soluble rapamycin derivatives modified with glutathione. More specifically, the present invention discloses a compound of formula I and the preparation method thereof, wherein R1 and R2 are as defined in the description. The compound of formula I can be used in inducing immunosuppression and in the treatment of diseases such as transplant rejection and solid tumor, etc.Type: ApplicationFiled: November 9, 2016Publication date: February 21, 2019Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Haibo Wang, Hongfu Kuang, Wei Zhang, Zhengjiang Cai, Tianmin Zhu, Xiaohe Zheng, Zhongwei Wu, Zhiqing Yang
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Publication number: 20190038694Abstract: Provided is a method for preparing a broccoli protein peptide. The method uses a broccoli protein as the raw material, and obtains a broccoli protein peptide powder through the steps of preprocessing, enzymatic hydrolysis, terminating enzymatic hydrolysis, separation, and drying and the like. Also provided is the use of the prepared broccoli protein peptide in resisting oxidation, reducing cholesterol and lowering blood lipids.Type: ApplicationFiled: May 3, 2016Publication date: February 7, 2019Inventors: Jidong WANG, Huan QI, Xiaohe ZHENG, Hui ZHANG, Yongdong WANG, Hailing TANG, Haiming LIN
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Publication number: 20180147248Abstract: Provided is a method for preparing a broccoli protein peptide. The method uses a broccoli protein as the raw material, and obtains a broccoli protein peptide powder through the steps of preprocessing, enzymatic hydrolysis, terminating enzymatic hydrolysis, separation, and drying and the like. Also provided is the use of the prepared broccoli protein peptide in resisting oxidation, reducing cholesterol and lowering blood lipids.Type: ApplicationFiled: May 3, 2016Publication date: May 31, 2018Inventors: Jidong WANG, Huan QI, Xiaohe ZHENG, Hui ZHANG, Yongdong WANG, Hailing TANG, Haiming LIN
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Publication number: 20180057530Abstract: The present invention relates to a compound represented by formula (I). The present invention also relates to the use of a compound represented by formula (I) in the treatment of disorders resulting from cell proliferation and/or angiogenesis or disorders associated with or accompanying cell proliferation and/or angiogenesis.Type: ApplicationFiled: April 1, 2016Publication date: March 1, 2018Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Niefang Yu, Jidong Wang, Xiaohe Zheng, Lifei Liu, Jiansheng Huang
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Patent number: 9487470Abstract: The present invention discloses a 4-((substituted phenyl)difluoromethyl)phenoxycarboxylic acid derivative and preparation process and use thereof. More specifically, the present invention relates to a compound of the following formula I, which is defined in the specification. The compounds according to the present invention can be used as PPAR agonists, and demonstrates a strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in blood plasma, and thus the compound according to the present invention can be used in the preparation of a medicament for treating or preventing hyperlipoidemia or cardio-cerebrovascular diseases caused by hyperlipoidemia, such as diabetes, atherosclerosis, stroke, coronary heart disease, etc. The present invention also relates to a novel intermediate compound for the preparation of the compound of formula I and preparation method thereof.Type: GrantFiled: April 25, 2013Date of Patent: November 8, 2016Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Jian Hong, Lifeng Cai, Hegeng Wei, Xiaoyu Liu, Xiaohe Zheng
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Patent number: 9346818Abstract: Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R1, R2 and A of formula (I) can be seen in the description.Type: GrantFiled: July 3, 2013Date of Patent: May 24, 2016Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Xuyang Zhao, Jinqing Zhong, Yongxiang Gong, Qifeng Zhu, Xiaoyu Liu, Xiaohe Zheng, Lifei Liu
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Patent number: 9346770Abstract: Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPAR?,?,?) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPAR?,?,?).Type: GrantFiled: June 18, 2011Date of Patent: May 24, 2016Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yaping Wang, Guojun Zheng, Peng Sun, Yi Li, Yingqiu Wu, Bin Liu, Xiaoyu Liu, Hua Bai, Hongyan Li, Xiaohe Zheng
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Publication number: 20150191480Abstract: Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R1, R2 and A of formula (I) can be seen in the description.Type: ApplicationFiled: July 3, 2013Publication date: July 9, 2015Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Hua Bai, Xuyang Zhao, Jinqing Zhong, Yongxiang Gong, Qifeng Zhu, Xiaoyu Liu, Xiaohe Zheng, Lifei Liu
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Publication number: 20150119458Abstract: The present invention discloses a 4-((substituted phenyl)difluoromethyl)phenoxycarboxylic acid derivative and preparation process and use thereof. More specifically, the present invention relates to a compound of the following formula I, which is defined in the specification. The compounds according to the present invention can be used as PPAR agonists, and demonstrates a strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in blood plasma, and thus the compound according to the present invention can be used in the preparation of a medicament for treating or preventing hyperlipoidemia or cardio-cerebrovascular diseases caused by hyperlipoidemia, such as diabetes, atherosclerosis, stroke, coronary heart disease, etc. The present invention also relates to a novel intermediate compound for the preparation of the compound of formula I and preparation method thereof.Type: ApplicationFiled: April 25, 2013Publication date: April 30, 2015Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Jian Hong, Lifeng Cai, Hegeng Wei, Xiaoyu Liu, Xiaohe Zheng
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Patent number: 8822519Abstract: The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype ? (PPAR?), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPAR? thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.Type: GrantFiled: August 7, 2009Date of Patent: September 2, 2014Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Chunhua Jin, Xiaoyu Liu, Zhenliang Chen, Xiaohe Zheng, Shoufeng Ming
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Patent number: 8623855Abstract: Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and R6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.Type: GrantFiled: August 9, 2010Date of Patent: January 7, 2014Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Xuyang Zhao, Xiaojie Xu, Xiaoyu Liu, Yuncai Zhang, Ying Chen, Xiaohe Zheng, Maojian Gu, Qifeng Zhu, Yong Zhang, Hairong Luo
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Publication number: 20130089613Abstract: Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPAR?,?,?) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPAR?,?,?).Type: ApplicationFiled: June 18, 2011Publication date: April 11, 2013Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yaping Wang, Guojun Zheng, Peng Sun, Yi Li, Yingqiu Wu, Bin Liu, Xiaoyu Liu, Hua Bai, Hongyan Li, Xiaohe Zheng
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Publication number: 20120208994Abstract: Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and R6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.Type: ApplicationFiled: August 9, 2010Publication date: August 16, 2012Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Hua Bai, Xuyang Zhao, Xiaojie Xu, Xiaoyu Liu, Yuncai Zhang, Ying Chen, Xiaohe Zheng, Maojian Gu, Qifeng Zhu, Yong Zhang, Hairong Luo
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Publication number: 20110319458Abstract: The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype ? (PPAR?), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPAR? thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.Type: ApplicationFiled: August 7, 2009Publication date: December 29, 2011Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Chunhua Jin, Xiaoyu Liu, Zhenliang Chen, Xiaohe Zheng, Shoufeng Ming