Patents by Inventor Xiaohu Ouyang

Xiaohu Ouyang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF
    Publication number: 20230303584
    Abstract: The present invention relates to compounds and compositions capable of acting as inhibitors of small ubiquitin-like modifier (SUMO) family of proteins. The compounds and compositions may be used in the treatment of cancer. There are disclosed, inter alia, methods of inhibiting an E1 enzyme, and compounds useful for inhibiting an E1 enzyme.
    Type: Application
    Filed: January 22, 2021
    Publication date: September 28, 2023
    Inventors: Xiaohu Ouyang, Miles Douglas Kubota, Andrew Stewart Tasker, Fang-Tsao Hong, Mary Walton, Victor J. Cee
  • SUMO inhibitor compounds and uses thereof
    Patent number: 11578079
    Abstract: There are disclosed, inter alia, methods of inhibiting an E1 enzyme, and compounds useful for inhibiting an E1 enzyme.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: February 14, 2023
    Assignees: City of Hope, Suvalent Therapeutics, Inc.
    Inventors: Yuan Chen, Xiaohu Ouyang, Sung Wook Yi, Ted Charles Judd
  • SUMO INHIBITOR COMPOUNDS AND USES THEREOF
    Publication number: 20220298171
    Abstract: There are disclosed, inter alia, methods of inhibiting an E1 enzyme, and compounds useful for inhibiting an E1 enzyme.
    Type: Application
    Filed: July 31, 2019
    Publication date: September 22, 2022
    Inventors: Yuan CHEN, Xiaohu OUYANG, Sung Wook YI, Ted Charles JUDD
  • SUMO INHIBITOR COMPOUNDS AND USES THEREOF
    Publication number: 20220177488
    Abstract: The present invention relates to compounds and compositions capable of acting as inhibitors of small ubiquitin-like modifier (SUMO) family of proteins. The compounds and compositions may be used in the treatment of cancer. There are disclosed, inter alia, methods of inhibiting an E1 enzyme, and compounds useful for inhibiting an E1 enzyme.
    Type: Application
    Filed: March 19, 2020
    Publication date: June 9, 2022
    Inventors: Xiaohu Ouyang, Miles Kubota, Ted Charles Judd, Andrew S. Tasker
  • Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
    Patent number: 9315484
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: April 19, 2016
    Assignee: The Board of Trustees—Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
  • Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
    Patent number: 9273025
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: March 1, 2016
    Assignee: The Board of Trustees—Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
  • Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
    Patent number: 9102651
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: August 11, 2015
    Assignee: The Board of Trustees-Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
  • Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
    Publication number: 20150105456
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 16, 2015
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
  • Substituted alkylamine derivatives and methods of use
    Patent number: 8642624
    Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: February 4, 2014
    Assignee: Amgen Inc.
    Inventors: Guoqing Chen, Jeffrey A. Adams, Jean E. Bemis, Shon Booker, Guolin Cai, Lucian V. DiPietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns-Meyer, Michael K. Handley, Qi Huang, Joseph L. Kim, Tae-Seong Kim, Alexander S. Kiselyov, Xiaohu Ouyang, Vinod F. Patel, Leon M. Smith, Markian M. Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael D. Croghan
  • SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE
    Publication number: 20130273004
    Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Guoqing CHEN, Jeffrey A. ADAMS, Jean E. BEMIS, Shon BOOKER, Guolin CAI, Lucian V. DIPIETRO, Celia DOMINGUEZ, Daniel ELBAUM, Julie GERMAIN, Stephanie D. GEUNS-MEYER, Michael K. HANDLEY, Qi HUANG, Joseph L. KIM, Tae-Seong KIM, Alexander S. KISELYOV, Xiaohu OUYANG, Vinod F. PATEL, Leon M. SMITH, II, Markian M. STEC, Andrew TASKER, Ning XI, Shimin XU, Chester YUAN, Michael CROGHAN
  • SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE
    Publication number: 20120065185
    Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
    Type: Application
    Filed: November 15, 2011
    Publication date: March 15, 2012
    Applicant: Amgen Inc.
    Inventors: Guoqing CHEN, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns-Meyer, Michael Handley, Qi Huang, Joseph L. Kim, Tae-Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod F. Patel, Leon M. Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan
  • Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
    Publication number: 20120010248
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Application
    Filed: August 22, 2011
    Publication date: January 12, 2012
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
  • Photocleavable Linker Methods and Compositions
    Publication number: 20110178281
    Abstract: Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydroxyquinoline. In other embodiments the photocleavable moiety is nitrodibenzofuran. In other embodiments the photocleavable moiety is 6-bromo-7-hydroxycoumarin-4-ylmethyl. The linkers find use in synthetic methods, including the generation of photocleavable oligonucleotides, e.g. caged morpholinos.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 21, 2011
    Inventors: James K. Chen, Surajit Sinha, Ilya Shestopalov, Xiaohu Ouyang
  • Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
    Publication number: 20110105602
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Application
    Filed: March 7, 2008
    Publication date: May 5, 2011
    Inventors: DARIA MOCHLY-ROSEN, Che-Hong Chen, Xiaohu Ouyang
  • Photocleavable linker methods and compositions
    Patent number: 7923562
    Abstract: Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydroxyquinoline. In other embodiments the photocleavable moiety is nitrodibenzofuran. In other embodiments the photocleavable moiety is 6-bromo-7-hydroxycoumarin-4-ylmethyl. The linkers find use in synthetic methods, including the generation of photocleavable oligonucleotides, e.g. caged morpholinos.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: April 12, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: James K. Chen, Surajit Sinha, Ilya Shestopalov, Xiaohu Ouyang
  • PHOTOCLEAVABLE LINKER METHODS AND COMPOSITIONS
    Publication number: 20100022761
    Abstract: Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydroxyquinoline. In other embodiments the photocleavable moiety is nitrodibenzofuran. In other embodiments the photocleavable moiety is 6-bromo-7-hydroxycoumarin-4-ylmethyl. The linkers find use in synthetic methods, including the generation of photocleavable oligonucleotides, e.g. caged morpholinos.
    Type: Application
    Filed: June 16, 2009
    Publication date: January 28, 2010
    Inventors: James K. Chen, Surajit Sinha, Ilya Shestopalov, Xiaohu Ouyang
  • Heterocyclic compounds and their use as anticancer agents
    Publication number: 20090318438
    Abstract: The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
    Type: Application
    Filed: September 25, 2008
    Publication date: December 24, 2009
    Inventors: Xiaoling Chen, Hai-Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid
  • Substituted amine derivatives and methods of use
    Patent number: 7514564
    Abstract: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: April 7, 2009
    Assignee: Amgen Inc.
    Inventors: Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L. Kim, Xiaohu Ouyang, Vinod F. Patel, Leon M. Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae-Seong Kim
  • MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20090082431
    Abstract: The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
    Type: Application
    Filed: March 7, 2008
    Publication date: March 26, 2009
    Inventors: Daria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
  • HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS
    Publication number: 20090048301
    Abstract: The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
    Type: Application
    Filed: July 9, 2004
    Publication date: February 19, 2009
    Applicant: IMCLONE SYSTEMS INCORPORATED
    Inventors: Xiaoling Chen, Hai-Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid