Abstract: Provided is a new compound capable of effectively inhibiting ATX. The compound is represented by formula I, or the compound is a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula I. In formula (I), R1 and R2 are independently selected from —H or —CH3, provided that: R1 and R2 are not —H at the same time or are not —CH3 at the same time.

Abstract: An intelligent obstacle detection system for an unmanned mine vehicle is provided to solve the problem of existing intelligent obstacle detection systems for unmanned mine vehicles cannot compare and analyze the actual driving data with the preset data and includes an intelligent detection platform, a route planning device, an obstacle detection device, a planning management device, an operation monitoring device, and a storage device. The route planning device is configured to perform route planning analysis for the unmanned mine vehicle to obtain a planned route of the unmanned mine vehicle. The planned route is sent to the obstacle detection device. The intelligent obstacle detection system can plan and analyze the travel route. By locking onto starting and target positions of the unmanned mine vehicles, and then obtaining point cloud data through the detection terminals and calculating with algorithms, the optimal planned route can be determined.

Abstract: The present invention relates to four-membered fused cyclic compounds and preparation methods and uses thereof, and specifically relates to four-membered fused cyclic compounds, preparation methods thereof and pharmaceutical compositions containing a therapeutically effective amount of the compound, as well as uses thereof as tyrosine kinase inhibitors, especially in the preparation of drugs that inhibit the tyrosine kinase activity of a protein selected from the group consisting of ABL1 protein, ABL2-related proteins and chimeric protein BCR-ABL1.

Abstract: The present invention discloses a charging device and method for open pit mine rock perforation blasting within the mining technology domain. The charging device includes a charging barrel with a detachable cover plate at the top and a bottom opening, housing a tray for explosive material. A jacking mechanism on the tray's side surface aids in positioning. A flexible interval gasbag separates the explosive and tray, with a wire passing hole at its center connected to an air pump via an inflation tube. A pressing plate and lifting mechanism in the cover plate facilitate lifting within the barrel. Additionally, a moving mechanism on the blast hole's top relocates the charging barrel. This innovation addresses challenges related to the cumbersome positioning and filling of existing powder explosives in open pit mine rock perforation blasting.

Abstract: A source-grid-load-storage networked collaborative frequency control method is disclosed, which comprises acquiring total active power ?P to be regulated during a secondary frequency regulation process of a power grid; performing frequency regulation by source-grid-load-storage of the power distribution system, allocating power regulation capacities, and determining whether the desired total active power is met after the frequency regulation; if the desired total active power is met, determining whether power of power generation units is out of limit; if the power of the power generation units is not out of limit, keeping active power of the power distribution system in balance to complete frequency regulation of the power grid; if the power of the power generation units is out of limit, correcting the power regulation capacities of the power generation units of the source-grid-load-storage and compensating a power difference to keep the active power of the power distribution system in balance.

Abstract: Disclosed are an emergency control method and system based on source-load-storage regulation and cutback. According to the method, output power of power generating sources is regulated according to a power regulating quantity and a frequency regulation requirement, an output power compensation and output frequency of each power generating source are maintained within permissible ranges, so that a balance between power supply and demand of a power distribution network is maintained; and standby energy-storage power stations are used to make up a power gap, and an external power supply system is used to assist in making up a power deficiency, so that large load disturbance can be handled make up the power gap.

Abstract: A multi-timescale voltage regulation method based on source-grid-load-storage multi -terminal collaboration of a power distribution network is disclosed, which comprises: establishing, based on a Petri network, a multi-mode switching control model based on voltage security event trigger to realize effective control of a global voltage; establishing multi-objective optimization taking into account a source-storage-load regulation cost and a network transmission loss to realize collaborative and dynamic control of controllable resources of a source terminal, a load terminal and a storage terminal in each operating mode; and establishing a source-storage-load multi-terminal collaboration-based distributed voltage control model based on voltage security event trigger over a short timescale by taking into account the problems of voltage magnitude being out of limit and voltage leap, and solving online an optimal control sequence of the source terminal, the load terminal and the storage terminal in a receding horiz

Abstract: Disclosed are an emergency control method and system based on source-load-storage regulation and cutback. According to the method, output power of power generating sources is regulated according to a power regulating quantity and a frequency regulation requirement, an output power compensation and output frequency of each power generating source are maintained within permissible ranges, so that a balance between power supply and demand of a power distribution network is maintained; and standby energy-storage power stations are used to make up a power gap, and an external power supply system is used to assist in making up a power deficiency, so that large load disturbance can be handled make up the power gap.

Abstract: A source-grid-load-storage networked collaborative frequency control method is disclosed, which comprises acquiring total active power ?P to be regulated during a secondary frequency regulation process of a power grid; performing frequency regulation by source-grid-load-storage of the power distribution system, allocating power regulation capacities, and determining whether the desired total active power is met after the frequency regulation; if the desired total active power is met, determining whether power of power generation units is out of limit; if the power of the power generation units is not out of limit, keeping active power of the power distribution system in balance to complete frequency regulation of the power grid; if the power of the power generation units is out of limit, correcting the power regulation capacities of the power generation units of the source-grid-load-storage and compensating a power difference to keep the active power of the power distribution system in balance.

Abstract: A networked control method for primary frequency regulation of a new energy power station based on a source-grid-load-storage networked cloud decision control system platform comprises: determining, according to historical operating data of a new energy power station, primary frequency regulation predictive values of power generation units of the new energy power station; determining, according to the primary frequency regulation predictive values, optimal control sequences of inverters of the power generation units at different times based on a pre-established inverter active power model, wherein the optimal control sequences comprise multiple control quantities of active power of the inverters; marking the optimal control sequences at the different times with time scales, sending the optimal control sequences to executing devices of the power generation units, receiving the optimal control sequences, and determining whether to store or not store the optimal control sequences; and determining the control qua

Abstract: A multi-timescale voltage regulation method based on source-grid-load-storage multi-terminal collaboration of a power distribution network is disclosed, which comprises: establishing, based on a Petri network, a multi-mode switching control model based on voltage security event trigger to realize effective control of a global voltage; establishing multi-objective optimization taking into account a source-storage-load regulation cost and a network transmission loss to realize collaborative and dynamic control of controllable resources of a source terminal, a load terminal and a storage terminal in each operating mode; and establishing a source-storage-load multi-terminal collaboration-based distributed voltage control model based on voltage security event trigger over a short timescale by taking into account the problems of voltage magnitude being out of limit and voltage leap, and solving online an optimal control sequence of the source terminal, the load terminal and the storage terminal in a receding horizo

Abstract: Provided are salts of a compound of formula (I) having an ATX inhibitory activity. The salts comprises inorganic acid salts or organic acid salts, and solid forms of the salts, such as crystal forms. The salts of the compound of formula (I) and their crystal forms according to the present disclosure have a good solubility, stability and hygroscopicity, and are more suitable for medicinal use. Moreover, their preparation methods are simple and convenient, and are suitable for large-scale production.

Abstract: A networked control method for primary frequency regulation of a new energy power station based on a source-grid-load-storage networked cloud decision control system platform comprises: determining, according to historical operating data of a new energy power station, primary frequency regulation predictive values of power generation units of the new energy power station; determining, according to the primary frequency regulation predictive values, optimal control sequences of inverters of the power generation units at different times based on a pre-established inverter active power model, wherein the optimal control sequences comprise multiple control quantities of active power of the inverters; marking the optimal control sequences at the different times with time scales, sending the optimal control sequences to executing devices of the power generation units, receiving the optimal control sequences, and determining whether to store or not store the optimal control sequences; and determining the control qua

Abstract: The present disclosure relates to pyrimidine compounds, and more specifically, relates to pyrimidine compounds, preparation methods thereof, and uses thereof in manufacture of medicaments. Provided is a compound represented by Formula (I) or a tautomer, stereoisomer, hydrate, solvate, pharmaceutical acceptable salt, or prodrug of the compound represented by Formula (I). The compound has a significant inhibitory effect on ATX enzyme, exhibits excellent liver metabolism stability, is metabolized more slowly in the human body, and has higher exposure.

Abstract: Provided is a new compound capable of effectively inhibiting ATX. The compound is represented by formula I, or the compound is a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula I. In formula (I), R1 and R2 are independently selected from —H or —CH3, provided that: R1 and R2 are not —H at the same time or are not —CH3 at the same time.

Abstract: The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

Abstract: The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

Abstract: A folding optical path transfer videometrics method for measuring the three-dimensional position and attitude of non-intervisible objects is disclosed. In one aspect, the method includes the following: constructing a folding optic path between an invisible target and a reference, disposing transfer station comprising a camera, a cooperating mark and a laser range finder on each break point in the folding optic path. The method may further include processing an image shot by each camera, accounting for the distance measured by the laser range finder, obtaining a position and posture information corresponding to each adjacent transfer station, summing the values from the reference to the invisible target, and achieving three-dimensional position and posture of the invisible target relating to the reference.

Abstract: A folding optical path transfer videometrics method for measuring the three-dimensional position and attitude of non-intervisible objects is disclosed. In one aspect, the method includes the following: constructing a folding optic path between an invisible target and a reference, disposing transfer station comprising a camera, a cooperating mark and a laser range finder on each break point in the folding optic path. The method may further include processing an image shot by each camera, accounting for the distance measured by the laser range finder, obtaining a position and posture information corresponding to each adjacent transfer station, summing the values from the reference to the invisible target, and achieving three-dimensional position and posture of the invisible target relating to the reference.