Patents by Inventor Xiaohua Zhang
Xiaohua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10696961Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.Type: GrantFiled: December 1, 2017Date of Patent: June 30, 2020Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Xiaohua Zhang, Susumu Mine, Ye Bai, Reginald Smith, Minfeng Xu, Weston Griffin, Kenneth Conway
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Publication number: 20200079133Abstract: The invention provides a silk fibroin-based anti-counterfeiting mark comprising a silk fibroin film layer and a gold film layer located on the silk fibroin film layer, and the area of the gold film layer is less than that of the silk fibroin film layer. The inventive also provides a method for preparing the silk fibroin-based optical anti-counterfeiting mark, the method comprises preparing an aqueous silk fibroin solution, coating the aqueous silk fibroin solution onto a substrate to obtain a silk fibroin film, and sputtering a layer of gold film on the silk fibroin film with a mask to obtain the silk fibroin-based optical anti-counterfeiting mark. In the invention a thin layer of Au film is sputtered on a silk fibroin film such that an anti-counterfeiting mark pattern appears at a high humidity, the method is simple and can significantly the production cost of optical anti-counterfeiting mark.Type: ApplicationFiled: July 25, 2016Publication date: March 12, 2020Inventors: Keqin ZHANG, Qingsong LI, Yu PENG, Ning QI, Xiaohua ZHANG
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Publication number: 20200079810Abstract: There are provided compounds of Formula I: various compositions thereof and methods for their use in the inhibition of ?-amylase.Type: ApplicationFiled: November 6, 2019Publication date: March 12, 2020Inventors: STEPHEN G. WITHERS, GARY D. BRAYER, LESLIE KAREN WILLIAMS, XIAOHUA ZHANG
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Patent number: 10539823Abstract: The present disclosure relates to compensating method for cell assembly. According to a deviation value of a key position of a measured array substrate, a compensation value of an exposure parameter of black matrix process of a color film substrate is calculated in real time by using historical measurement data of batches. The compensation value is fed back to a manufacturing apparatus in real time. The manufacturing apparatus corrects the key parameter of the apparatus timely according to the compensation value of the exposure parameter of the black matrix, to manufacture a color film substrate matching with the array substrate.Type: GrantFiled: August 15, 2017Date of Patent: January 21, 2020Assignees: BOE TECHNOLOGY GROUP CO., LTD., ORDOS YUANSHENG OPTOELECTRONICS CO., LTD.Inventors: Xiaohua Zhang, Xiahong Bai, Dong Yan, Hao Lei
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Patent number: 10500325Abstract: A wearable filtrating artificial kidney device, comprising a transfusion inlet (2), a blood pump (3), an arterial pressure detector (4), a blood filter (7), a venous pressure detector (8) and an air detector (9), wherein the transfusion inlet (2), the blood pump (3), the arterial pressure detector (4), a resin hemoperfusion apparatus (5), an active carbon hemoperfusion apparatus (6), the blood filter (7), the venous pressure detector (8) and the air detector (9) are connected sequentially; a liquid waste outlet of the blood filter (7) is connected with an ultrafiltration control pump (10). Glomerulus filtration can be simulated to achieve the goal of removing toxins and excessive moisture in the blood by virtue of ultrafiltration of the blood filter (7). A dialyzate and a complicated dialyzate circulating device are not used for the device, so that the volume and weight of the device can be reduced greatly, and the device can be worn conveniently.Type: GrantFiled: September 23, 2016Date of Patent: December 10, 2019Inventors: Changsheng Zhao, Baihai Su, Weifeng Zhao, Shudong Sun, Chen Wang, Zhenqiang Shi, Qiang Liu, Xiaohua Zhang, Ping Fu, Jianhui Zhou
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Publication number: 20190249130Abstract: A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removiType: ApplicationFiled: February 9, 2018Publication date: August 15, 2019Inventors: Weston Blaine Griffin, Xiaohua Zhang, Reginald Donovan Smith, Vandana Keskar
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Publication number: 20190169594Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.Type: ApplicationFiled: December 1, 2017Publication date: June 6, 2019Inventors: Xiaohua Zhang, Susumu Mine, Ye Bai, Reginald Smith, Minfeng Xu, Weston Griffin, Kenneth Conway
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Patent number: 10302919Abstract: A mirrorless large-aperture ultra wide-angle lens relates to a wide-angle lens of which a full angle of view is over 100 degrees, and sequentially comprises two parts from an object side to an image side: a first lens group Gr1 having a positive diopter and a second lens group Gr2 having a positive diopter; when an object moves closer from infinity, the first lens group Gr1 is fixed, the second lens group Gr2 moves towards the object to implement an ultra wide-angle microlens which is in focus and meets the following conditional expression: 2.0?F1/F2?10, wherein F1: a focal length of the first lens group Gr1; and F2: a focal length of the first lens group Gr2. The Invention can provide a miniaturized, high-performance, low-cost ultra wide-angle lens whose angle of view is over 100 degrees, achieving strong universality.Type: GrantFiled: May 5, 2017Date of Patent: May 28, 2019Assignee: ANHUI CHANGGENG OPTICS TECHNOLOGY CO., LTD.Inventor: Xiaohua Zhang
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Patent number: 10287548Abstract: The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.Type: GrantFiled: June 29, 2016Date of Patent: May 14, 2019Assignee: General Electric CompanyInventors: Vandana Keskar, Weston Blaine Griffin, Xiaohua Zhang
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Publication number: 20190106124Abstract: Disclosed is an interconnected transportation network system, wherein same is related to the field of transportation facilities and control, and comprises a main transportation system, a transfer system and an entry/exit system. The main transportation system is formed of a closed annular rail vehicle, and the annular train moves continuously on a T-shaped track to fulfil a passenger transportation task by means of multi-point drive. The transfer system (intercommunication) is of the same structure as that of the main transportation system, and the passengers transfer between main transportation lines by means of the transfer system. The entry/exit system (terminal) is formed of an annular buffer vehicle system and a stepping speed control system, and the passengers enter or exit the main transportation lines in a self-service manner by means of the entry/exit system.Type: ApplicationFiled: March 31, 2017Publication date: April 11, 2019Inventor: Xiaohua ZHANG
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Patent number: 10100277Abstract: Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems in stirred tank bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential.Type: GrantFiled: March 21, 2016Date of Patent: October 16, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Brian Michael Davis, Kenneth Roger Conway, Xiaohua Zhang
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Patent number: 10098600Abstract: Cone Beam Breast CT, (CBBCT) is a three-dimensional breast imaging modality with high soft tissue contrast, high spatial resolution and no tissue overlap. CBBCT-based computer aided diagnosis (CBBCT-CAD) technology is a clinically useful tool for breast cancer detection and diagnosis that will help radiologists to make more efficient and accurate decisions. The CBBCT-CAD is able to: 1) use 3D algorithms for image artifact correction, mass and calcification detection and characterization, duct imaging and segmentation, vessel imaging and segmentation, and breast density measurement, 2) present composite information of the breast including mass and calcifications, duct structure, vascular structure and breast density to the radiologists to aid them in determining the probability of malignancy of a breast lesion.Type: GrantFiled: June 9, 2016Date of Patent: October 16, 2018Assignees: University of Rochester, Koning CorporationInventors: Ruola Ning, Xiaohua Zhang, David L. Conover, Shaohua Liu
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Publication number: 20180196344Abstract: A mask management system and a method for using a mask are provided. The mask management system includes: a mask feeding module, configured to provide at least one mask group, each of the at least one mask group including one cassette and a plurality of masks placed in the cassette; a mask detecting and processing module, configured to detect the plurality of masks in the mask group and perform a corresponding mask processing on a mask required to be processed according to a detection result; and a mask classification module, configured to readjust a mask which is processed and qualified into the cassette of the mask group to which the mask belongs.Type: ApplicationFiled: March 28, 2017Publication date: July 12, 2018Inventors: Xiaohua ZHANG, Shaohua LIU, Zhenyu LIU, Dong YAN, Fuyi CUI
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Patent number: 10013866Abstract: The present invention provides a production equipment monitoring method and system, and the method comprises: receiving production equipment alarm information; determining abnormal production equipment according to the production equipment alarm information, and determining a user group corresponding to the abnormal production equipment according to preset correspondence between production equipment and user group; and sending the production equipment alarm information to a user in the determined user group in a preset alarm manner. As a result, alarm information can be sent to the corresponding user(s) in the preset alarm manner the first time an abnormity in the production equipment is found, so as to notify related personnel to handle the abnormity timely and accurately.Type: GrantFiled: July 25, 2016Date of Patent: July 3, 2018Assignees: BOE Technology Group Co., Ltd., Ordos Yuansheng Optoelectronics Co., Ltd.Inventors: Dong Yan, Xiaohua Zhang, Shuang Liu
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Publication number: 20180164584Abstract: A shift converter relates to the field of camera lens technologies, and sequentially comprises, from an object side to an image side, a first lens group G1 having a positive diopter and a second lens group G2 having a negative diopter; when a focal length of the first lens group G1 is F1, a focal length of the second lens group is F2, and a focal length of the whole shift converter is F, the following conditional expression is met: 1.0?|F1/F2|?4.5 (1). The Invention can provide a shift converter which is connected on an image space side of a lens of a single-lens reflex camera, small in size, low in costs, good in performance, and strong in universality, and turns an ordinary lens into a tilt-shift lens.Type: ApplicationFiled: May 5, 2017Publication date: June 14, 2018Inventor: Xiaohua ZHANG
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Publication number: 20180149842Abstract: A mirrorless large-aperture ultra wide-angle lens relates to a wide-angle lens of which a full angle of view is over 100 degrees, and sequentially comprises two parts from an object side to an image side: a first lens group Gr1 having a positive diopter and a second lens group Gr2 having a positive diopter; when an object moves closer from infinity, the first lens group Gr1 is fixed, the second lens group Gr2 moves towards the object to implement an ultra wide-angle microlens which is in focus and meets the following conditional expression: 2.0?F1/F2?10, wherein F1: a focal length of the first lens group Gr1; and F2: a focal length of the first lens group Gr2. The Invention can provide a miniaturized, high-performance, low-cost ultra wide-angle lens whose angle of view is over 100 degrees, achieving strong universality.Type: ApplicationFiled: May 5, 2017Publication date: May 31, 2018Inventor: Xiaohua ZHANG
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Patent number: 9944894Abstract: Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems on rocking platform bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential.Type: GrantFiled: December 2, 2015Date of Patent: April 17, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Brian Michael Davis, Kenneth Roger Conway, Evelina Roxana Loghin, Xiaohua Zhang
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Publication number: 20180074366Abstract: The present disclosure relates to compensating method for cell assembly. According to a deviation value of a key position of a measured array substrate, a compensation value of an exposure parameter of black matrix process of a color film substrate is calculated in real time by using historical measurement data of batches. The compensation value is fed back to a manufacturing apparatus in real time. The manufacturing apparatus corrects the key parameter of the apparatus timely according to the compensation value of the exposure parameter of the black matrix, to manufacture a color film substrate matching with the array substrate.Type: ApplicationFiled: August 15, 2017Publication date: March 15, 2018Inventors: Xiaohua ZHANG, Xiahong BAI, Dong YAN, Hao LEI
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Publication number: 20180002667Abstract: The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.Type: ApplicationFiled: June 29, 2016Publication date: January 4, 2018Inventors: Vandana Keskar, Weston Blaine Griffin, Xiaohua Zhang
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Publication number: 20170263104Abstract: The present invention provides a production equipment monitoring method and system, and the method comprises: receiving production equipment alarm information; determining abnormal production equipment according to the production equipment alarm information, and determining a user group corresponding to the abnormal production equipment according to preset correspondence between production equipment and user group; and sending the production equipment alarm information to a user in the determined user group in a preset alarm manner. As a result, alarm information can be sent to the corresponding user(s) in the preset alarm manner the first time an abnormity in the production equipment is found, so as to notify related personnel to handle the abnormity timely and accurately.Type: ApplicationFiled: July 25, 2016Publication date: September 14, 2017Inventors: Dong YAN, Xiaohua ZHANG, Shuang LIU