Patents by Inventor Xiaohua Zhang

Xiaohua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10696961
    Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 30, 2020
    Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Xiaohua Zhang, Susumu Mine, Ye Bai, Reginald Smith, Minfeng Xu, Weston Griffin, Kenneth Conway
  • Publication number: 20200079133
    Abstract: The invention provides a silk fibroin-based anti-counterfeiting mark comprising a silk fibroin film layer and a gold film layer located on the silk fibroin film layer, and the area of the gold film layer is less than that of the silk fibroin film layer. The inventive also provides a method for preparing the silk fibroin-based optical anti-counterfeiting mark, the method comprises preparing an aqueous silk fibroin solution, coating the aqueous silk fibroin solution onto a substrate to obtain a silk fibroin film, and sputtering a layer of gold film on the silk fibroin film with a mask to obtain the silk fibroin-based optical anti-counterfeiting mark. In the invention a thin layer of Au film is sputtered on a silk fibroin film such that an anti-counterfeiting mark pattern appears at a high humidity, the method is simple and can significantly the production cost of optical anti-counterfeiting mark.
    Type: Application
    Filed: July 25, 2016
    Publication date: March 12, 2020
    Inventors: Keqin ZHANG, Qingsong LI, Yu PENG, Ning QI, Xiaohua ZHANG
  • Publication number: 20200079810
    Abstract: There are provided compounds of Formula I: various compositions thereof and methods for their use in the inhibition of ?-amylase.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 12, 2020
    Inventors: STEPHEN G. WITHERS, GARY D. BRAYER, LESLIE KAREN WILLIAMS, XIAOHUA ZHANG
  • Patent number: 10539823
    Abstract: The present disclosure relates to compensating method for cell assembly. According to a deviation value of a key position of a measured array substrate, a compensation value of an exposure parameter of black matrix process of a color film substrate is calculated in real time by using historical measurement data of batches. The compensation value is fed back to a manufacturing apparatus in real time. The manufacturing apparatus corrects the key parameter of the apparatus timely according to the compensation value of the exposure parameter of the black matrix, to manufacture a color film substrate matching with the array substrate.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: January 21, 2020
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., ORDOS YUANSHENG OPTOELECTRONICS CO., LTD.
    Inventors: Xiaohua Zhang, Xiahong Bai, Dong Yan, Hao Lei
  • Patent number: 10500325
    Abstract: A wearable filtrating artificial kidney device, comprising a transfusion inlet (2), a blood pump (3), an arterial pressure detector (4), a blood filter (7), a venous pressure detector (8) and an air detector (9), wherein the transfusion inlet (2), the blood pump (3), the arterial pressure detector (4), a resin hemoperfusion apparatus (5), an active carbon hemoperfusion apparatus (6), the blood filter (7), the venous pressure detector (8) and the air detector (9) are connected sequentially; a liquid waste outlet of the blood filter (7) is connected with an ultrafiltration control pump (10). Glomerulus filtration can be simulated to achieve the goal of removing toxins and excessive moisture in the blood by virtue of ultrafiltration of the blood filter (7). A dialyzate and a complicated dialyzate circulating device are not used for the device, so that the volume and weight of the device can be reduced greatly, and the device can be worn conveniently.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: December 10, 2019
    Inventors: Changsheng Zhao, Baihai Su, Weifeng Zhao, Shudong Sun, Chen Wang, Zhenqiang Shi, Qiang Liu, Xiaohua Zhang, Ping Fu, Jianhui Zhou
  • Publication number: 20190249130
    Abstract: A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removi
    Type: Application
    Filed: February 9, 2018
    Publication date: August 15, 2019
    Inventors: Weston Blaine Griffin, Xiaohua Zhang, Reginald Donovan Smith, Vandana Keskar
  • Publication number: 20190169594
    Abstract: Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material to facilitate magnetic cell isolation without adjustment of magnetic field parameters between isolation procedures using different magnetic particle sizes. When the magnetic cell isolation holder is coupled to a magnetic field generator, a first passage corresponding to a smaller particle size is positioned in a magnetic field where the magnetic field characteristics are different relative to a second passage, of a second holder or in the same holder, for use with another bead size.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 6, 2019
    Inventors: Xiaohua Zhang, Susumu Mine, Ye Bai, Reginald Smith, Minfeng Xu, Weston Griffin, Kenneth Conway
  • Patent number: 10302919
    Abstract: A mirrorless large-aperture ultra wide-angle lens relates to a wide-angle lens of which a full angle of view is over 100 degrees, and sequentially comprises two parts from an object side to an image side: a first lens group Gr1 having a positive diopter and a second lens group Gr2 having a positive diopter; when an object moves closer from infinity, the first lens group Gr1 is fixed, the second lens group Gr2 moves towards the object to implement an ultra wide-angle microlens which is in focus and meets the following conditional expression: 2.0?F1/F2?10, wherein F1: a focal length of the first lens group Gr1; and F2: a focal length of the first lens group Gr2. The Invention can provide a miniaturized, high-performance, low-cost ultra wide-angle lens whose angle of view is over 100 degrees, achieving strong universality.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: May 28, 2019
    Assignee: ANHUI CHANGGENG OPTICS TECHNOLOGY CO., LTD.
    Inventor: Xiaohua Zhang
  • Patent number: 10287548
    Abstract: The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: May 14, 2019
    Assignee: General Electric Company
    Inventors: Vandana Keskar, Weston Blaine Griffin, Xiaohua Zhang
  • Publication number: 20190106124
    Abstract: Disclosed is an interconnected transportation network system, wherein same is related to the field of transportation facilities and control, and comprises a main transportation system, a transfer system and an entry/exit system. The main transportation system is formed of a closed annular rail vehicle, and the annular train moves continuously on a T-shaped track to fulfil a passenger transportation task by means of multi-point drive. The transfer system (intercommunication) is of the same structure as that of the main transportation system, and the passengers transfer between main transportation lines by means of the transfer system. The entry/exit system (terminal) is formed of an annular buffer vehicle system and a stepping speed control system, and the passengers enter or exit the main transportation lines in a self-service manner by means of the entry/exit system.
    Type: Application
    Filed: March 31, 2017
    Publication date: April 11, 2019
    Inventor: Xiaohua ZHANG
  • Patent number: 10100277
    Abstract: Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems in stirred tank bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: October 16, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Brian Michael Davis, Kenneth Roger Conway, Xiaohua Zhang
  • Patent number: 10098600
    Abstract: Cone Beam Breast CT, (CBBCT) is a three-dimensional breast imaging modality with high soft tissue contrast, high spatial resolution and no tissue overlap. CBBCT-based computer aided diagnosis (CBBCT-CAD) technology is a clinically useful tool for breast cancer detection and diagnosis that will help radiologists to make more efficient and accurate decisions. The CBBCT-CAD is able to: 1) use 3D algorithms for image artifact correction, mass and calcification detection and characterization, duct imaging and segmentation, vessel imaging and segmentation, and breast density measurement, 2) present composite information of the breast including mass and calcifications, duct structure, vascular structure and breast density to the radiologists to aid them in determining the probability of malignancy of a breast lesion.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: October 16, 2018
    Assignees: University of Rochester, Koning Corporation
    Inventors: Ruola Ning, Xiaohua Zhang, David L. Conover, Shaohua Liu
  • Publication number: 20180196344
    Abstract: A mask management system and a method for using a mask are provided. The mask management system includes: a mask feeding module, configured to provide at least one mask group, each of the at least one mask group including one cassette and a plurality of masks placed in the cassette; a mask detecting and processing module, configured to detect the plurality of masks in the mask group and perform a corresponding mask processing on a mask required to be processed according to a detection result; and a mask classification module, configured to readjust a mask which is processed and qualified into the cassette of the mask group to which the mask belongs.
    Type: Application
    Filed: March 28, 2017
    Publication date: July 12, 2018
    Inventors: Xiaohua ZHANG, Shaohua LIU, Zhenyu LIU, Dong YAN, Fuyi CUI
  • Patent number: 10013866
    Abstract: The present invention provides a production equipment monitoring method and system, and the method comprises: receiving production equipment alarm information; determining abnormal production equipment according to the production equipment alarm information, and determining a user group corresponding to the abnormal production equipment according to preset correspondence between production equipment and user group; and sending the production equipment alarm information to a user in the determined user group in a preset alarm manner. As a result, alarm information can be sent to the corresponding user(s) in the preset alarm manner the first time an abnormity in the production equipment is found, so as to notify related personnel to handle the abnormity timely and accurately.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: July 3, 2018
    Assignees: BOE Technology Group Co., Ltd., Ordos Yuansheng Optoelectronics Co., Ltd.
    Inventors: Dong Yan, Xiaohua Zhang, Shuang Liu
  • Publication number: 20180164584
    Abstract: A shift converter relates to the field of camera lens technologies, and sequentially comprises, from an object side to an image side, a first lens group G1 having a positive diopter and a second lens group G2 having a negative diopter; when a focal length of the first lens group G1 is F1, a focal length of the second lens group is F2, and a focal length of the whole shift converter is F, the following conditional expression is met: 1.0?|F1/F2|?4.5 (1). The Invention can provide a shift converter which is connected on an image space side of a lens of a single-lens reflex camera, small in size, low in costs, good in performance, and strong in universality, and turns an ordinary lens into a tilt-shift lens.
    Type: Application
    Filed: May 5, 2017
    Publication date: June 14, 2018
    Inventor: Xiaohua ZHANG
  • Publication number: 20180149842
    Abstract: A mirrorless large-aperture ultra wide-angle lens relates to a wide-angle lens of which a full angle of view is over 100 degrees, and sequentially comprises two parts from an object side to an image side: a first lens group Gr1 having a positive diopter and a second lens group Gr2 having a positive diopter; when an object moves closer from infinity, the first lens group Gr1 is fixed, the second lens group Gr2 moves towards the object to implement an ultra wide-angle microlens which is in focus and meets the following conditional expression: 2.0?F1/F2?10, wherein F1: a focal length of the first lens group Gr1; and F2: a focal length of the first lens group Gr2. The Invention can provide a miniaturized, high-performance, low-cost ultra wide-angle lens whose angle of view is over 100 degrees, achieving strong universality.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 31, 2018
    Inventor: Xiaohua ZHANG
  • Patent number: 9944894
    Abstract: Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems on rocking platform bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: April 17, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Brian Michael Davis, Kenneth Roger Conway, Evelina Roxana Loghin, Xiaohua Zhang
  • Publication number: 20180074366
    Abstract: The present disclosure relates to compensating method for cell assembly. According to a deviation value of a key position of a measured array substrate, a compensation value of an exposure parameter of black matrix process of a color film substrate is calculated in real time by using historical measurement data of batches. The compensation value is fed back to a manufacturing apparatus in real time. The manufacturing apparatus corrects the key parameter of the apparatus timely according to the compensation value of the exposure parameter of the black matrix, to manufacture a color film substrate matching with the array substrate.
    Type: Application
    Filed: August 15, 2017
    Publication date: March 15, 2018
    Inventors: Xiaohua ZHANG, Xiahong BAI, Dong YAN, Hao LEI
  • Publication number: 20180002667
    Abstract: The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.
    Type: Application
    Filed: June 29, 2016
    Publication date: January 4, 2018
    Inventors: Vandana Keskar, Weston Blaine Griffin, Xiaohua Zhang
  • Publication number: 20170263104
    Abstract: The present invention provides a production equipment monitoring method and system, and the method comprises: receiving production equipment alarm information; determining abnormal production equipment according to the production equipment alarm information, and determining a user group corresponding to the abnormal production equipment according to preset correspondence between production equipment and user group; and sending the production equipment alarm information to a user in the determined user group in a preset alarm manner. As a result, alarm information can be sent to the corresponding user(s) in the preset alarm manner the first time an abnormity in the production equipment is found, so as to notify related personnel to handle the abnormity timely and accurately.
    Type: Application
    Filed: July 25, 2016
    Publication date: September 14, 2017
    Inventors: Dong YAN, Xiaohua ZHANG, Shuang LIU