Abstract: The present application provides a timer, including a base, a driving shaft, and an indicator arm. The driving shaft is rotatably mounted on the base and selectably rotates relative to the base. The indicator arm includes a second support and a plurality of hour blocks. The second support is rotatably connected to the driving shaft. The hour blocks each include a second block body and a second gear. The second block body is rotatably connected to the second support. The second gear is fixedly connected to the second block body. Second protrusion is correspondingly arranged on a rotation path of the second gear around the driving shaft. The second gear has second tooth grooves. The second protrusion selectably extends into the second tooth grooves to drive the second gear to rotate relative to the second support so as to drive the hour blocks to rotate relative to the second support.

Abstract: Corneal stromal scars are the leading cause of corneal blindness. The present invention relates to methods and compositions useful in therapies for this pathological condition. The invention provides corneal stromal stem cells and certain other stem cells and as well as exosome polynucleotides produced by such cells, and methods for making and using these cells and compositions. The invention is based upon the discovery that exosomes and their associate active components obtained from these cells comprise agents having the same capacity as corneal stromal stem cells to reduce scarring and prevent scar formation in patients having corneal damage.

Abstract: The disclosure provides a comprehensive limbal stem cell deficiency diagnostic and staging system that combines observations of physiological parameters such as clinical presentation, central cornea basal cell density, central corneal epithelial thickness, and total corneal nerve fiber length. It has been discovered that the methodology disclosed herein can both accurately and objectively diagnose limbal stem cell deficiency as well as stage its severity.

Abstract: Corneal stromal scars are the leading cause of corneal blindness. The present invention relates to methods and compositions useful in therapies for this pathological condition. The invention provides corneal stromal stem cells and certain other stem cells and as well as exosome polynucleotides produced by such cells, and methods for making and using these cells and compositions. The invention is based upon the discovery that exosomes and their associate active components obtained from these cells comprise agents having the same capacity as corneal stromal stem cells to reduce scarring and prevent scar formation in patients having corneal damage.

Abstract: A human limbal epithelial stem xenobiotic free cell culture system is provided. The cell culture system typically includes a cell culture media comprising isoproterenol, Human Epidermal Growth Factor (EGF), N2 supplement, hydrocortisone, and an antibiotic. This cell culture media can efficiently propagate undifferentiated LSCs in the absence xenobiotic cells. These systems provide an optimized way to culture LSCs for use in human transplantation (e.g. in patients suffering from limbal stem cell deficiency) by minimizing the risk of cross-contamination and/or reagent toxicity to transplant recipients.

Abstract: The present application refers to a process for preparing of nanostructured metal oxides such as cobalt oxide and transition metal incorporated cobalt oxides and nickel aluminium oxides and nickel metal supported on aluminium oxide using plant material such as spent tea leaves as a hard template and the use of such catalysts for water oxidation.

Abstract: The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional (3D) sandwich method/system in which human limbal stem/progenitor cells and feeder cells are separately cultured on opposite sides of a porous membrane.

Abstract: The invention disclosed herein provides systems and methods designed to facilitate human limbal stem/progenitor cell culture including a novel 3-dimensional (3D) sandwich method/system in which human limbal stem/progenitor cells and feeder cells are separately cultured on opposite sides of a porous membrane.