Abstract: The present invention relates to a compound of formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for treating diseases related to WEE1 activity.

Abstract: The present disclosure relates to a nonwoven substrate having a top surface and an opposite bottom surface, and comprising a plurality of apertures, wherein the top surface has a first contact angle of no lower than about 90 degrees as measured according to Contact Angle Test, wherein the bottom surface has a second contact angle of lower than about 90 degrees as measured according to Contact Angle Test, and wherein the plurality of apertures comprise at least one aperture having at least three adjacent apertures that are spaced apart from by an edge-to-edge space no greater than about 2.5 mm. Also disclosed herein is an absorbent article having a topsheet comprising the nonwoven substrate.

Abstract: The present disclosure relates to a nonwoven substrate having a top surface and an opposite bottom surface comprising: an upper layer forming the top surface of the nonwoven substrate, the upper layer comprising hydrophobic fibers, and a lower layer forming the bottom surface of the nonwoven substrate, the lower layer comprising hydrophilic fibers, wherein the top surface of the nonwoven substrate has a first contact angle of no lower than about 90 degrees as measured according to Contact Angle Test, wherein the bottom surface of the nonwoven substrate has a second contact angle of lower than about 90 degrees as measured according to Contact Angle Test, wherein the nonwoven has a unitary structure, and wherein the upper layer has a thickness no greater than about 1400 ?m as measured according to the Thickness Test.

Abstract: A length adjuster on a wearable device includes an arc-shaped shell and a length fine-adjustment mechanism. A first connection rack, a second connection rack, a gear, a button and a return spring of a gear shaft are provided in the arc-shaped shell. The first connection rack, the second connection rack and the gear are meshed with one another. The gear shaft is connected to a clockwork spring mechanism. The gear shaft and the length fine-adjustment mechanism are in a clutch connection. A unidirectional rotation-prevention structure is provided in the length fine-adjustment mechanism, and the unidirectional rotation-prevention structure allows the length fine-adjustment mechanism to drive the gear shaft to rotate in a rotation direction for enabling a clockwork spring to be stretched, and prevents the gear shaft from rotating in the direction opposite to the rotation direction. The length adjuster is provided with a release mechanism.

Abstract: The present invention relates to a three-dimensional nonwoven comprising a first side, a second side, a protruded first area comprising an upper portion formed in the first side and a lower portion formed in the second side, and a second area comprising a plurality of deformations, wherein the upper portion has a shape memory index higher than a shape memory index of the lower portion, an absorbent article comprising the three-dimensional nonwoven, and a process for producing the three-dimensional nonwoven.

Abstract: The present invention relates to an apparatus for deforming a web to created deformed nonwoven which comprises a pair of counter-rotating rolls that form a nip therebetween, the pair of rolls comprising: a first roll comprising a surface, a plurality of protrusions extending radially outwardly from the surface of the first roll, and a plurality of concaves formed inwardly from the surface of the first roll; and a second roll comprising a surface; and a process for producing a deformed web comprising the steps of (a) forming a fibrous web; (b) subjecting the fibrous web to bonding treatment to bond at least part of fibers constituting the fibrous web to obtain a precursor nonwoven; and (c) subjecting the precursor nonwoven to a deformation forming unit comprising an apparatus according to the present invention.

Abstract: A cutting apparatus for resecting a distal face of a femur prior to implanting a femoral component of a total knee prosthesis, comprises an elongate rod adapted for inserting into an intramedullary canal of the femur, a distal femoral cutting block, and a distal femoral jig assembly. The jig assembly can position the distal femoral cutting block on either left leg or right leg. It includes a distal femoral jig having at least one passage for slidingly receiving the rod with a preset valgus angle and a distal end face being adapted for abutting against on the distal face of the femur of either left leg or right leg dependent on its two flip orientations.

Abstract: Provided is a length adjuster on a wearable device, comprising an arc-shaped shell and a length fine-adjustment mechanism, wherein a first connection rack, a second connection rack, a gear, and a button and a return spring of a gear shaft are provided in the arc-shaped shell; the first connection rack, the second connection rack and the gear are meshed with one another, the gear shaft is connected to a clockwork spring mechanism, the gear shaft and the length fine-adjustment mechanism are in a clutch connection, and the gear shaft and the length fine-adjustment mechanism may be in a clutch connection; and a unidirectional rotation-prevention structure is provided in the length fine-adjustment mechanism, and the unidirectional rotation-prevention structure allows the length fine-adjustment mechanism to drive the gear shaft to rotate in a rotation direction for enabling a clockwork spring to be stretched, and prevents the gear shaft from rotating in the direction opposite to the rotation direction.

Abstract: A cutting apparatus for resecting a distal face of a femur prior to implanting a femoral component of a total knee prosthesis, comprises an elongate rod adapted for inserting into an intramedullary canal of the femur, a distal femoral cutting block, and a distal femoral jig assembly. The jig assembly can position the distal femoral cutting block on either left leg or right leg. It includes a distal femoral jig having at least one passage for slidingly receiving the rod with a preset valgus angle and a distal end face being adapted for abutting against on the distal face of the femur of either left leg or right leg dependent on its two flip orientations.

Abstract: A cutting apparatus for resecting a distal face of a femur prior to implanting a femoral component of a total knee prosthesis, comprises an elongate rod adapted for inserting into an intramedullary canal of the femur, a distal femoral cutting block, and a distal femoral jig assembly. The jig assembly can position the distal femoral cutting block on either left leg or right leg. It includes a distal femoral jig having at least one passage for slidingly receiving the rod with a preset valgus angle and a distal end face being adapted for abutting against on the distal face of the femur of either left leg or right leg dependent on its two flip orientations.

Abstract: A cutting apparatus for resecting a distal face of a femur prior to implanting a femoral component of a total knee prosthesis, comprises an elongate rod adapted for inserting into an intramedullary canal of the femur, a distal femoral cutting block, and a distal femoral jig assembly. The jig assembly can position the distal femoral cutting block on either left leg or right leg. It includes a distal femoral jig having at least one passage for slidingly receiving the rod with a preset valgus angle and a distal end face being adapted for abutting against on the distal face of the femur of either left leg or right leg dependent on its two flip orientations.

Abstract: A protein-phospholipid dispersion preparation in a drug delivery system is provided, in which the weight ratio of protein to phospholipid is 1:300-300:1 and the particle size is between 5 nm and 1000 nm. The preparation process of the said preparation contains the mixture of protein phase and phospholipid phase and the homogenization process. The said drug delivery system can be used in many different pharmaceutical agents.

Abstract: A composite emulsifier, contains two or more emulsifiers selected from phospholipid, PEG emulsifier and poloxamer-like substance, and may contain cryoprotectant. An emulsion prepared from the composite emulsifier and a preparation method of the emulsion.