Patents by Inventor Xiaohui He

Xiaohui He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
    Patent number: 8158634
    Abstract: The invention provides compounds having Formula Ia, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and Y are as defined in the specification; as well as pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: April 17, 2012
    Assignee: IRM LLC
    Inventors: Hong Liu, Xiaohui He, Ha-Soon Choi, Kunyong Yang, David Woodmansee, Zhicheng Wang, David Archer Ellis, Baogen Wu, Yun He, Truc Ngoc Nguyen
  • COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS
    Publication number: 20110172278
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120.
    Type: Application
    Filed: June 23, 2009
    Publication date: July 14, 2011
    Applicant: IRM LLC
    Inventors: Xiaohui He, Xuefeng Zhu, Kunyong Yang, Robert Epple, Hong Liu
  • Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors
    Patent number: 7968557
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: June 28, 2011
    Assignee: Novartis AG
    Inventors: Ha-Soon Choi, Zhicheng Wang, Nathanael Schiander Gray, Xiang-ju Gu, Xiaohui He, Yun He, Tao Jiang, Yi Liu, Wendy Richmond, Taebo Sim, Kunyong Yang
  • PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20110112096
    Abstract: The invention provides novel pyrimidine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK).
    Type: Application
    Filed: June 24, 2009
    Publication date: May 12, 2011
    Applicant: ITM LLC
    Inventors: Thomas H. Marsilje, Wenshuo Lu, Bei Chen, Xiaohui He, Songchun Jiang, Kunyong Yang
  • PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20110112063
    Abstract: The invention provides novel pyrimidine derivatives of formula I and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK).
    Type: Application
    Filed: June 24, 2009
    Publication date: May 12, 2011
    Inventors: Thomas H. Marsilje, Wenshuo Lu, Bei Chen, Xiaohui He, Christian Cho-Hua Lee, Songchun Jiang, Kunyong Yang
  • COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS
    Publication number: 20110053897
    Abstract: Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
    Type: Application
    Filed: July 26, 2010
    Publication date: March 3, 2011
    Applicant: IRM LLC
    Inventors: Jianwei CHE, Bei Chen, Qiang Ding, Xueshi Hao, Xiaohui He, Songchun Jiang, Qihui Jin, Yunho Jin, Hong Liu, Yahua Liu, Barun Okram, Tetsuo Uno, Xu Wu, Kunyong Yang, Xuefeng Zhu
  • 2-BIPHENYLAMINO-4-AMINOPYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20100298295
    Abstract: The invention provides novel pyrimidine derivatives of formula (1) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK).
    Type: Application
    Filed: August 27, 2008
    Publication date: November 25, 2010
    Applicant: IRM LLC
    Inventors: Thomas H. Marsilje, Wenshuo Lu, Bei Chen, Xiaohui He, Badry Bursulaya, Christian Cho-Hua Lee, Nathanael S. Gray
  • COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY
    Publication number: 20100234365
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
    Type: Application
    Filed: December 12, 2007
    Publication date: September 16, 2010
    Applicant: IRM LLC
    Inventors: Hong Liu, Xiaohui He, Dean Phillips, Xuefeng Zhu, Kunyong Yang, Thomas Lau, Baogen Wu, Yongping Xie, Truc Ngoc Nguyen, Xing Wang
  • ANTICONVULSANT AND ANXIOLYTIC METHODS OF USING RECEPTOR SUBTYPE SELECTIVE AGENTS
    Publication number: 20100130481
    Abstract: Methods of using orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anticonvulsant and anxiolytic activity with reduced sedative, hypnotic, muscle relaxant, or ataxic effects.
    Type: Application
    Filed: January 8, 2010
    Publication date: May 27, 2010
    Inventors: James M. Cook, Qi Huang, Xiaohui He, Xioeyan Li, Jianming Yu, Dongmel Han
  • Pyrrolidones with anti-HIV activity
    Patent number: 7601742
    Abstract: The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: October 13, 2009
    Assignee: IRM LLC
    Inventors: Baogen Wu, Yun He, Truc Ngoc Nguyen, Kelli L. Kuhen, David Archer Ellis, Tao Jiang, Xiaohui He, Kunyong Yang, Badry Bursulaya
  • COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY
    Publication number: 20090247517
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
    Type: Application
    Filed: October 26, 2005
    Publication date: October 1, 2009
    Inventors: Hong Liu, Xiaohui He, Ha-Soon Choi, Kunyong Yang, David H. Woodmansee, Zhicheng Wang, David Archer Ellis, Baogen Wu, Yun He, Truc Ngoc Nguyen
  • Azolopyrimidines as Inhibitors of Cannabinoid 1 Activity
    Publication number: 20090247556
    Abstract: The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
    Type: Application
    Filed: March 30, 2007
    Publication date: October 1, 2009
    Applicant: IRM LLC
    Inventors: Xiaohui He, Kunyong Yang, Hong Liu, David Archer Ellis
  • Bicyclic compounds and compositions as PDF inhibitors
    Patent number: 7579363
    Abstract: This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: August 25, 2009
    Assignee: IRM LLC
    Inventors: Valentina Molteni, Xiaohui He, Yun He, Andreas Kreusch, Juliet Nabakka, Kunyong Yang
  • Pyrrolidones with anti-HIV activity
    Patent number: 7495016
    Abstract: The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
    Type: Grant
    Filed: October 21, 2003
    Date of Patent: February 24, 2009
    Assignee: IRM LLC
    Inventors: Baogen Wu, Yun He, Truc Ngoc Nguyen, Kelli L. Kuhen, David Archer Ellis, Tao Jiang, Xiaohui He, Kunyong Yang, Badry Bursulaya
  • Phenyl-Substituted Pyrrolidones
    Publication number: 20080287516
    Abstract: The present invention relates to phenyl-substituted pyrrolidones and compounds related to phenyl-substituted pyrrolidones. One use of these compounds is for the inhibition of viruses, e.g., HIV. The invention further relates to methods of malting these compounds, methods of identifying the efficacy of these compounds, and methods of using these compounds to inhibit or prevent HIV infection and related disease states such as AIDS.
    Type: Application
    Filed: January 30, 2006
    Publication date: November 20, 2008
    Applicant: IRM LLC
    Inventors: Baogen Wu, Truc Ngoc Nguyen, David Archer Ellis, Xiaohui He, Beth Marie Anaclerio, Kunyong Yang, Ha-soon Choi, Zhicheng Wang, Thomas H. Marsilje, Yun He
  • PYRROLIDONES WITH ANTI-HIV ACTIVITY
    Publication number: 20080255136
    Abstract: The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
    Type: Application
    Filed: April 22, 2008
    Publication date: October 16, 2008
    Applicant: IRM LLC
    Inventors: Baogen Wu, Yun He, Truc Nguyen, Kelli L. Kuhen, David Archer Ellis, Tao Jiang, Xiaohui He, Kunyong Yang, Badry Bursulaya
  • ANXIOLYTIC AGENTS WITH REDUCED SEDATIVE AND ATAXIC EFFECTS
    Publication number: 20080108605
    Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Applicant: WISYS TECHNOLOGY FOUNDATION, INC.
    Inventors: James Cook, Qi Huang, Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han
  • Anxiolytic Agents With Reduced Sedative And Ataxic Effects
    Publication number: 20070299058
    Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.
    Type: Application
    Filed: June 24, 2007
    Publication date: December 27, 2007
    Applicant: WiSys Technology Foundation, Inc.
    Inventors: Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han, James Cook, Qi Huang
  • BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS
    Publication number: 20070259852
    Abstract: This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: June 27, 2007
    Publication date: November 8, 2007
    Inventors: Valentina Molteni, Xiaohui He, Yun He, Andreas Kreusch, Juliet Nabakka, Kunyong Yang
  • Compounds and Compositions as Protein Kinase Inhibitors
    Publication number: 20070225306
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.
    Type: Application
    Filed: February 14, 2005
    Publication date: September 27, 2007
    Applicant: IRM LLC
    Inventors: Ha-Soon Choi, Zhicheng Wang, Nathanael Gay, Xiang-Ju Gu, Xiaohui He, Yun He, Toa Jiang, Yi Liu, Windy Richmond, Taebo Sim, Kunyong Yang