Patents by Inventor Xiaohui S. Lin

Xiaohui S. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compare-MS: method rapid, sensitive and accurate detection of DNA methylation
    Patent number: 7906288
    Abstract: The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: March 15, 2011
    Assignee: The Johns Hopkins University
    Inventors: William G. Nelson, Xiaohui S. Lin, Angelo M. Demarzo, Srinivasan Nasubramanian
  • Compare-MS: Method Rapid, Sensitive and Accurate Detection of DNA Methylation
    Publication number: 20090197263
    Abstract: The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.
    Type: Application
    Filed: January 4, 2007
    Publication date: August 6, 2009
    Inventors: William G. Nelson, Xiaohui S. Lin, Angelo M. Demarzo, Srinivasan Nasubramanian