Patents by Inventor Xiaohui Sun

Xiaohui Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210047359
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 18, 2021
    Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Daqing Sun, Qiuping Ye, Jared Moore, Tatiana Zavorotinskaya, Brian R. Blank, Yosup Rew, Kejia Wu, Liusheng Zhu, Johnny Pham, Hiroyuki Kawai
  • Publication number: 20210023095
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 28, 2021
    Inventors: Daqing SUN, Lawrence R. MCGEE, Xiaohui DU, Liusheng ZHU, Xuelei YAN, Yosup REW, John EKSTEROWICZ, Julio C. MEDINA, Haiying ZHOU, Minna Delarae BALBAS, Valeria R. FANTIN
  • Publication number: 20210017220
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 21, 2021
    Inventors: Daqing SUN, Lawrence R. MCGEE, Xiaohui DU, Liusheng ZHU, Xuelei YAN, Yosup REW, John EKSTEROWICZ, Julio C. MEDINA, Haiying ZHOU, Minna Delarae BALBAS, Valeria R. FANTIN
  • Publication number: 20210017219
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 21, 2021
    Inventors: Daqing SUN, Lawrence R. McGEE, Xiaohui DU, Liusheng ZHU, Xuelei YAN, Yosup REW, John EKSTEROWICZ, Julio C. MEDINA, Valeria R. FANTIN, Haiying ZHOU, Minna Delarae BALBAS
  • Publication number: 20210002324
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 7, 2021
    Inventors: Daqing SUN, Lawrence R. MCGEE, Xiaohui DU, Liusheng ZHU, Xuelei YAN, Yosup REW, John EKSTEROWICZ, Julio C. MEDINA, Haiying ZHOU, Minna Delarae BALBAS, Valeria R. FANTIN
  • Publication number: 20210000853
    Abstract: Disclosed are a pharmaceutical composition and an application thereof. The pharmaceutical composition of the present invention comprises the following components in parts by weight: 2-20 parts of phenolic acids, 0.5-5 parts of flavonoids, 0.005-0.5 part of tanshinones, 5-20 parts of saponins, and 10-18 parts of volatile oils. The pharmaceutical composition has the functions of protecting against myocardial damage and treating heart failure.
    Type: Application
    Filed: April 4, 2019
    Publication date: January 7, 2021
    Inventors: Shiuiping ZHOU, He SUN, Yiqian ZHANG, Xiaohui MA, Jiawen SHI, Yi HE, Xinxin LI, Jing WANG, Xiaoqing LI, Lijun FAN, Jingjing ZHANG
  • Patent number: 10874636
    Abstract: Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R1 is —H, —OH, —F, —Cl, —Br, —I, —OCH3, —OCF3, —OCHF2, —OCH2F, —CF3, —CHF2, —CH2F, —CH3, —CH3CH2, —CF3CH2, —CN, —NO2, —NH2 or —COOR5; R2 is H, C1-C10 linear alkyl, C3-C10 branched alkyl, C3-C10 cyclic alkyl, C1-C10 hydroxyalkyl or a N-substituted piperazine-derived group; or R2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: December 29, 2020
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Min Han, Xiaohui Ma, Wangyi Zhou, Yanyong Liu, Yanchuan Li, Jing Wang, Shuiping Zhou, He Sun, Yonghong Zhu
  • Patent number: 10836789
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: November 17, 2020
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Daqing Sun, Lawrence R. McGee, Xiaohui Du, Liusheng Zhu, Xuelei Yan, Yosup Rew, John Eksterowicz, Julio C. Medina, Valeria R. Fantin, Haiying Zhou, Minna Delarae Balbas
  • Publication number: 20200358939
    Abstract: A system and method for determining a dimension of a target. The method includes: determining a camera parameter, the camera parameter including at least one of a focal length, a yaw angle, a roll angle, a pitch angle, or a height of one or more cameras; acquiring a first image and a second image of an target captured by the one or more cameras; generating a first corrected image and a second corrected image by correcting the first image and the second image; determining a parallax between a pixel in the first corrected image and a corresponding pixel in the second corrected image; determining an outline of the target; and determining a dimension of the target based at least in part on the camera parameter, the parallax, and the outline of the target.
    Type: Application
    Filed: June 8, 2020
    Publication date: November 12, 2020
    Applicant: ZHEJIANG DAHUA TECHNOLOGY CO., LTD.
    Inventors: Wei LU, Qiankun LI, Shizhu PAN, Jichao GENG, Xiaohui SUN, Haijiang PAN, Jinting WANG
  • Publication number: 20200347090
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: November 2, 2018
    Publication date: November 5, 2020
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Erica L. JACKSON, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA
  • Patent number: 10825444
    Abstract: The present disclosure provides a speech synthesis method and apparatus, a computer device and a readable medium. The method comprises: when problematic speech appears in speech splicing and synthesis, predicting a time length of a state of each phoneme corresponding to a target text corresponding to the problematic speech and a base frequency of each frame, according to pre-trained time length predicting model and base frequency predicting model; according to the time length of the state of each phoneme corresponding to the target text and the base frequency of each frame, using a pre-trained speech synthesis model to synthesize speech corresponding to the target text; wherein the time length predicting model, the base frequency predicting model and the speech synthesis model are all obtained by training based on a speech library resulting from speech splicing and synthesis.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: November 3, 2020
    Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Yu Gu, Xiaohui Sun
  • Patent number: 10803851
    Abstract: The present disclosure provides a method for processing speech splicing and synthesis and apparatus, a computer device and a readable medium. The method comprises: expanding a speech library according to a pre-trained speech synthesis model and an obtained synthesized text; the speech library before the expansion comprises manually-collected original language materials; using the expanded speech library to perform speech splicing and synthesis processing. According to the technical solution of the present embodiment, the speech library is expanded so that the speech library includes sufficient language materials. As such, when speech splicing processing is performed according to the expanded speech library, it is possible to select more speech segments, and thereby improve coherence and naturalness of the effect of speech synthesis so that the speech synthesis effect is very coherent with very good naturalness and can sufficiently satisfy the user's normal use.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: October 13, 2020
    Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Xiaohui Sun, Yu Gu
  • Publication number: 20200291058
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Inventors: Daqing SUN, Lawrence R. McGEE, Xiaohui DU, Liusheng ZHU, Xuelei YAN, Yosup REW, John EKSTEROWICZ, Julio C. MEDINA, Valeria R. FANTIN, Haiying ZHOU, Minna Delarae BALBAS
  • Publication number: 20200281433
    Abstract: The present invention provides a drainage control device and a cleaning robot, the drainage control device includes a water tank body and a middle cover sealingly disposed on an upper portion of the water tank body; wherein the middle cover is provided with a water inlet, an air inlet, and a steering engine assembly engaged with the air inlet and configured to adjust an opening size of the air inlet to control an air intake amount, the water inlet is mounted with a sealing cover, and a lower portion of the water tank body is provided with at least one water outlet. The present invention precisely controls the air intake amount through the steering gear assembly and the air inlet, and can accurately control the water output under the action of the atmospheric pressure, which is very suitable for the occasion where the displacement needs precise control.
    Type: Application
    Filed: July 6, 2019
    Publication date: September 10, 2020
    Inventor: XIAOHUI SUN
  • Patent number: 10723759
    Abstract: The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: July 28, 2020
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Daqing Sun, Lawrence R. McGee, Xiaohui Du, Liusheng Zhu, Xuelei Yan, Yosup Rew, John Eksterowicz, Julio C. Medina, Valeria R. Fantin, Haiying Zhou, Minna Delarae Balbas
  • Patent number: 10712782
    Abstract: A front cover assembly includes a frame, a cover glass, and a waterproof glue. The frame has a receiving cavity. The cover glass is partially received in the frame. The cover glass has a lateral face facing the frame. The cover glass has a step portion located at the lateral face. A first gap is defined between a first face of the step portion of the cover glass and a first wall of the frame, and a second gap is defined between a second face of the step portion of the cover glass and a second wall of the frame. A waterproof glue fills the first and second gaps. The first and second faces of the step portion from an obtuse angle therebetween, which faces the first and second walls of the frame. The present disclosure also relates to a terminal.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: July 14, 2020
    Assignee: GUANGDONG OPPO MOBILE TELECOMMUNICATIONS CORP., LTD.
    Inventors: Yimei Tang, Yong Li, Hong Zou, Yi Sun, Wei Zhang, Xinfeng Liao, Zhiqin Hu, Xiaohui Wang, Bing Liu, Yuchu Xu, Wei Chen
  • Patent number: 10681257
    Abstract: A system and method for determining a dimension of a target. The method includes: determining a camera parameter, the camera parameter including at least one of a focal length, a yaw angle, a roll angle, a pitch angle, or a height of one or more cameras; acquiring a first image and a second image of an target captured by the one or more cameras; generating a first corrected image and a second corrected image by correcting the first image and the second image; determining a parallax between a pixel in the first corrected image and a corresponding pixel in the second corrected image; determining an outline of the target; and determining a dimension of the target based at least in part on the camera parameter, the parallax, and the outline of the target.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: June 9, 2020
    Assignee: ZHEJIANG DAHUA TECHNOLOGY CO., LTD.
    Inventors: Wei Lu, Qiankun Li, Shizhu Pan, Jichao Geng, Xiaohui Sun, Haijiang Pan, Jinting Wang
  • Patent number: 10654204
    Abstract: A method for forming an encapsulation assembly, and a vehicle window are provided. The method includes: providing a reinforcement component; forming a primer layer covering a surface of the reinforcement component; performing a heating treatment on the reinforcement component after the primer layer is formed, to elevate a temperature of the reinforcement component; and injecting a gasket material in a mold onto the surface of the reinforcement component with elevated temperature to form a gasket. The vehicle window includes a glass; and the encapsulation assembly formed by the above method. The gasket may bind with the primer layer more closely. That is to say, binding force between the reinforcement component and the gasket may be increased. In this way, the gasket may not easily detach from the reinforcement component.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: May 19, 2020
    Assignee: SAINT-GOBAIN GLASS FRANCE
    Inventors: Yang Sun, Ce Shi, Xiaohui Guo
  • Publication number: 20200104340
    Abstract: The disclosed embodiments provide a system for performing A/B testing using quantile metrics. During operation, the system obtains metrics collected during an A/B test. Next, the system calculates an asymptotic estimate of a variance of a quantile for the metrics based on a lack of statistical independence of the metrics from one another. The system then determines a statistical significance of a result of the A/B test based on the asymptotic estimate of the variance. Finally, the system outputs the statistical significance with the result for use in assessing an effect of a treatment variant of the A/B test on the quantile.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 2, 2020
    Applicant: Microsoft Technology Licensing, LLC
    Inventors: Min Liu, Xiaohui Sun, Maneesh Varshney, Ya Xu
  • Publication number: 20200093844
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Application
    Filed: May 9, 2018
    Publication date: March 26, 2020
    Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Erica L. JACKSON, Daqing SUN, Qiuping YE, Jared MOORE