Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: A high-strength stainless steel rotor and a method for preparing the same, are provided. The high-strength stainless steel rotor, including the following element components by mass percentage: C: 0.03-0.050%, Cr: 14.90-15.80%, Ni: 5.00-5.70%, Cu: 2.20-2.80%, (Nb+Ta): 0.35-0.44%, Mo: 0.45-0.54%, V: 0.06-0.10%, Si: 0.20-0.60%, Mn: 0.40-0.80%, P?0.010%, S?0.010%, O?0.003%, and the balance of iron and inevitable impurities.

Abstract: An apparatus for preventing and controlling secondary generation of hydrates in a wellbore during depressurization exploitation of offshore natural gas hydrates includes a gas recovery pipe column, a water recovery pipe column, a gas-liquid mixed transportation pipe section, a data collecting and processing unit, and a reaction control apparatus; according to characteristics of different exploitation pipe columns, three injection pipelines and three monitoring points are arranged to predict dynamic changes in a secondary generation risk of the hydrates throughout the wellbore; measures for preventing and controlling the secondary generation of the hydrates are taken at different pipe column positions by the integrated utilization of inhibitor injection, heating for pipe columns, the additional arrangement of electric submersible pumps, and other methods.

Abstract: A hot extrusion die for a special-shaped square pipe includes a die cavity sleeve with a special-shaped cavity. A hot extrusion mandrel is arranged in the die cavity sleeve. An area between the die cavity sleeve and the hot extrusion mandrel forms a die cavity hole. A first extrusion diversion hole and a second extrusion diversion hole are arranged below the die cavity hole. An integral centroid of the die cavity hole is located at a circle center of a radial cross section of the die cavity sleeve. Further disclosed is a hot extrusion integral forming method for a special-shaped square pipe, including: heating and expanding a blank material; heating the blank material again after expanding; performing hot extrusion on the blank material; and cooling the formed special-shaped square pipe in air to a room temperature, and inspecting surface quality and mechanical properties of the special-shaped square pipe.

Abstract: A drilling well underground kick processing method and device are described.

Abstract: A drilling well underground kick processing method and device are described.

Abstract: A system and method for determining a dimension of a target. The method includes: determining a camera parameter, the camera parameter including at least one of a focal length, a yaw angle, a roll angle, a pitch angle, or a height of one or more cameras; acquiring a first image and a second image of an target captured by the one or more cameras; generating a first corrected image and a second corrected image by correcting the first image and the second image; determining a parallax between a pixel in the first corrected image and a corresponding pixel in the second corrected image; determining an outline of the target; and determining a dimension of the target based at least in part on the camera parameter, the parallax, and the outline of the target.

Abstract: The present invention provides a method and equipment for optimizing hydraulic parameters of deepwater managed pressure drilling in real time. The method comprises: acquiring overflow parameters in the current drilling process, performing preprocessing and feature extraction on the overflow parameters, and inputting the overflow parameters into trained support vector machine identification models for overflow judgment. If overflow occurs at the current drilling depth, reducing an opening of a throttle valve and increasing a displacement of a submarine pump, measuring a wellhead back pressure and calculating a bottom hole pressure, and judging whether overflow continues is performed.

Abstract: An active control method and system for wellbore pressure in open-cycle drilling in marine natural gas hydrates. The system comprises a drilling system, a drilling fluid injection system, and a data processing system for conducting the drilling operation.

Abstract: An active control method and control device for wellbore pressure in the open-cycle drilling of marine natural gas hydrates comprises following steps: (1) optimized design of drilling parameter; (2) carry out open-cycle drilling according to the designed drilling parameters; (3) utilize the APWD to monitor the bottom-hole temperature and the bottom-hole pressure in real time for real-time correction of the wellbore annulus temperature and pressure calculation models; determine whether a hydrate decomposition has occurred in the annulus and then infer whether a shallow gas intrusion has occurred in the bottom hole; (4) Intelligent active control: control and adjust the mixed density of drilling fluid, the injection displacement of drilling fluid as well as the injection temperature of drilling fluid and the pump pressure in wellhead automatically during the well killing based on the real-time treatment results of the computer terminal for the signal fluctuations detected by the APWD.

Abstract: A system and method for determining a dimension of a target. The method includes: determining a camera parameter, the camera parameter including at least one of a focal length, a yaw angle, a roll angle, a pitch angle, or a height of one or more cameras; acquiring a first image and a second image of an target captured by the one or more cameras; generating a first corrected image and a second corrected image by correcting the first image and the second image; determining a parallax between a pixel in the first corrected image and a corresponding pixel in the second corrected image; determining an outline of the target; and determining a dimension of the target based at least in part on the camera parameter, the parallax, and the outline of the target.

Abstract: The present disclosure provides a speech synthesis method and apparatus, a computer device and a readable medium. The method comprises: when problematic speech appears in speech splicing and synthesis, predicting a time length of a state of each phoneme corresponding to a target text corresponding to the problematic speech and a base frequency of each frame, according to pre-trained time length predicting model and base frequency predicting model; according to the time length of the state of each phoneme corresponding to the target text and the base frequency of each frame, using a pre-trained speech synthesis model to synthesize speech corresponding to the target text; wherein the time length predicting model, the base frequency predicting model and the speech synthesis model are all obtained by training based on a speech library resulting from speech splicing and synthesis.

Abstract: The present disclosure provides a method for processing speech splicing and synthesis and apparatus, a computer device and a readable medium. The method comprises: expanding a speech library according to a pre-trained speech synthesis model and an obtained synthesized text; the speech library before the expansion comprises manually-collected original language materials; using the expanded speech library to perform speech splicing and synthesis processing. According to the technical solution of the present embodiment, the speech library is expanded so that the speech library includes sufficient language materials. As such, when speech splicing processing is performed according to the expanded speech library, it is possible to select more speech segments, and thereby improve coherence and naturalness of the effect of speech synthesis so that the speech synthesis effect is very coherent with very good naturalness and can sufficiently satisfy the user's normal use.

Abstract: The present invention provides a drainage control device and a cleaning robot, the drainage control device includes a water tank body and a middle cover sealingly disposed on an upper portion of the water tank body; wherein the middle cover is provided with a water inlet, an air inlet, and a steering engine assembly engaged with the air inlet and configured to adjust an opening size of the air inlet to control an air intake amount, the water inlet is mounted with a sealing cover, and a lower portion of the water tank body is provided with at least one water outlet. The present invention precisely controls the air intake amount through the steering gear assembly and the air inlet, and can accurately control the water output under the action of the atmospheric pressure, which is very suitable for the occasion where the displacement needs precise control.

Abstract: A system and method for determining a dimension of a target. The method includes: determining a camera parameter, the camera parameter including at least one of a focal length, a yaw angle, a roll angle, a pitch angle, or a height of one or more cameras; acquiring a first image and a second image of an target captured by the one or more cameras; generating a first corrected image and a second corrected image by correcting the first image and the second image; determining a parallax between a pixel in the first corrected image and a corresponding pixel in the second corrected image; determining an outline of the target; and determining a dimension of the target based at least in part on the camera parameter, the parallax, and the outline of the target.

Abstract: The disclosed embodiments provide a system for performing A/B testing using quantile metrics. During operation, the system obtains metrics collected during an A/B test. Next, the system calculates an asymptotic estimate of a variance of a quantile for the metrics based on a lack of statistical independence of the metrics from one another. The system then determines a statistical significance of a result of the A/B test based on the asymptotic estimate of the variance. Finally, the system outputs the statistical significance with the result for use in assessing an effect of a treatment variant of the A/B test on the quantile.

Abstract: The present disclosure provides a method for processing speech splicing and synthesis and apparatus, a computer device and a readable medium. The method comprises: expanding a speech library according to a pre-trained speech synthesis model and an obtained synthesized text; the speech library before the expansion comprises manually-collected original language materials; using the expanded speech library to perform speech splicing and synthesis processing. According to the technical solution of the present embodiment, the speech library is expanded so that the speech library includes sufficient language materials. As such, when speech splicing processing is performed according to the expanded speech library, it is possible to select more speech segments, and thereby improve coherence and naturalness of the effect of speech synthesis so that the speech synthesis effect is very coherent with very good naturalness and can sufficiently satisfy the user's normal use.

Abstract: The present disclosure provides a speech synthesis method and apparatus, a computer device and a readable medium. The method comprises: when problematic speech appears in speech splicing and synthesis, predicting a time length of a state of each phoneme corresponding to a target text corresponding to the problematic speech and a base frequency of each frame, according to pre-trained time length predicting model and base frequency predicting model; according to the time length of the state of each phoneme corresponding to the target text and the base frequency of each frame, using a pre-trained speech synthesis model to synthesize speech corresponding to the target text; wherein the time length predicting model, the base frequency predicting model and the speech synthesis model are all obtained by training based on a speech library resulting from speech splicing and synthesis.

Abstract: A system and method for determining a dimension of a target. The method includes: determining a camera parameter, the camera parameter including at least one of a focal length, a yaw angle, a roll angle, a pitch angle, or a height of one or more cameras; acquiring a first image and a second image of an target captured by the one or more cameras; generating a first corrected image and a second corrected image by correcting the first image and the second image; determining a parallax between a pixel in the first corrected image and a corresponding pixel in the second corrected image; determining an outline of the target; and determining a dimension of the target based at least in part on the camera parameter, the parallax, and the outline of the target.

Abstract: The invention provides compositions for the inhibition of bacterial adhesion. The composition can include nanocrystalline cellulose (NCC) and a water-soluble polymer, which form an NCC hydrogel in water. The NCC hydrogel can be used to treat or coat devices such as a catheter, whereby the NCC hydrogel inhibits bacterial adhesion to the catheter surface to thereby inhibit biofilm formation and growth of bacteria on the catheter surface. The compositions and devices can thus be useful for inhibiting or preventing conditions such as urinary tract infections.