Abstract: The present invention provides an anti-TrkA antibody or an antigen-binding fragment thereof, a preparation method, and an application thereof. The present invention also provides an isolated polynucleotide encoding the anti-TrkA antibody or the antigen-binding fragments thereof, and a vector comprising the isolated polynucleotide. The present invention also provides a use of the antibody or the antigen-binding fragment thereof in the preparation of a drug for treating pain.

Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.

Abstract: Provided are an anti-NGF antibody or an antigen-binding fragment thereof, a preparation method and an application thereof. Also provided is an isolated polynucleotide encoding the anti-NGF antibody or the antigen-binding fragment thereof, as well as a vector containing the isolated polynucleotide. Also provided is use of the antibody or the antigen-binding fragment thereof of the present invention in preparing the medicament for the treatment of NGF-mediated diseases or disorders.

Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.

Abstract: A subset of humanized anti-PD-1 antibodies that inhibit binding of PD-L1 and PD-L2 to human PD-1. These binding proteins modulate the immune system through the manipulation of the PD-1 signaling pathway to treat immune dysfunctional disorders, including for example cancers.

Abstract: A subset of humanized anti-PD-1 antibodies that inhibit binding of PD-L1 and PD-L2 to human PD-1. These binding proteins modulate the immune system through the manipulation of the PD-1 signaling pathway to treat immune dysfunctional disorders, including for example cancers.

Abstract: A method for detecting malicious code on web pages includes: obtaining a function list by executing a specified code and a predefined object code; parsing the specified code and obtaining variable values according to a parsing result and the function list; and determining whether a malicious code exists on web pages according to variable values. A device for detecting malicious code on web pages is also provided.

Abstract: Methods of and screens for detection of exogenous ligands in a biological sample without prior knowledge of the chemical structure of the ligand are disclosed. The novel screens and methods may be used to detect Illicit use of performance-enhancing steroids, which use has proliferated among a wide range of professional and amateur athletes. While these athletes were previously able to evade detection because the steroids were unknown to authorities, the present strategies can successfully detect such “designer steroids” without prior knowledge of their existence.