Abstract: In the present disclosure, doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model, were treated with PNU-125096, a positive allosteric modulator of ?7 nicotinic acetylcholine receptor (?7 nAChR) and effects on Tat-induced behavioral impairments and neuropathologies were observed. This disclosure shows that PNU-125096 treatment significantly improved locomotor, learning and memory deficits of iTat mice while inhibited glial activation and increased PSD-95 expression in the cortex and hippocampus of iTat mice. ?7 nAChR knockout eliminated the protective effects of PNU-125096 on iTat mice. In addition, inhibition of p38 phosphorylation by SB239063, a p38 MAPK-specific inhibitor, exacerbated Tat neurotoxicity in iTat mice. These findings demonstrated for the first time that ?7 nAChR activation led to protection against HAND and suggest that ?7 nAChR and PNU-125096 hold significant promise for development of therapeutics for HAND.

Abstract: In the present disclosure, doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model, were treated with PNU-125096, a positive allosteric modulator of ?7 nicotinic acetylcholine receptor (?7 nAChR) and effects on Tat-induced behavioral impairments and neuropathologies were observed. This disclosure shows that PNU-125096 treatment significantly improved locomotor, learning and memory deficits of iTat mice while inhibited glial activation and increased PSD-95 expression in the cortex and hippocampus of iTat mice. ?7 nAChR knockout eliminated the protective effects of PNU-125096 on iTat mice. In addition, inhibition of p38 phosphorylation by SB239063, a p38 MAPK-specific inhibitor, exacerbated Tat neurotoxicity in iTat mice. These findings demonstrated for the first time that ?7 nAChR activation led to protection against HAND and suggest that ?7 nAChR and PNU-125096 hold significant promise for development of therapeutics for HAND.

Abstract: A laser 3D printing method with orthopedic function, comprising the following steps: step one, measuring a projection characteristic of each spot within a scanning plane, to obtain a deformation quantity of a focused light spot at the each spot within the scanning plane before rectifying; step two, setting compensation quantities of the each spot within the scanning plane of a light spot orthopedic device according to the measuring result of the step one, so that the size of the focused light spot at the each spot within the scanning plane is consistent; step three, turning on the laser, and dynamically matching the light spot orthopedic device and a scanning device to perform the laser 3D printing. The laser 3D printing method and system thereof with orthopedic function could ensure the size of the focused light spot is consistent within the scanning plane, thereby ensuring the quality of 3D printing.

Abstract: A fiber laser oscillator comprises an active fiber for providing a lasing light having a selected wavelength band, a saturable absorber assembly coupled to a first end of the active fiber, a pump source for providing a pump light having wavelengths except the selected wavelength band, an optical component coupled to the second end of the active fiber and the pump source. The optical component comprises a thin film filter for transmitting the lasing light for a first time and reflecting the pump light and a reflector for reflecting the lasing light transmitted for the first time through the thin film filter. The lasing light reflected by the reflector transmits through the thin film filter for a second time and overlaps with the pump light reflected by the thin film filter.

Abstract: An ultrafast laser system and application thereof, relates to the technical field of laser, and the system comprises a control module, a laser, an optical path module, a movable platform, a visual locating module, and the control module is connected to the laser and controls an operation of the laser, and the control module is connected to the movable platform and controls a movement of the movable platform, and the optical path module is connected to the laser and is used for transmitting a laser light generated by the laser to the movable platform, and the control module is connected to the visual locating module and controls the visual locating module to position a laser emitting position at a position, and the laser is an ultrafast laser. The system is applied to equipment for removing mole, freckle, or tattoo, which has the advantages of fewer traumas and no pain.

Abstract: A method for correcting wavefront distribution of an optical system by laser, mainly utilizes the action of the laser to form a desired refractive index spatial distribution inside an optical component, thereby correcting a wavefront distortion existing in an optical system, or to obtain an optical system having a desired wavefront distribution. The optical component processed by the method could effectively correct the wavefront distortion existing in the optical system, to meet specific use requirements, and the optical component could be used in various optical systems. At the same time, the method has the characteristics of fast speed, computer-aided one-step forming and no subsequent processing, and is a new method for optical system design and wavefront distortion correction.

Abstract: A laser 3D printing method for metal workpiece and system thereof, and the method comprises the following steps: step one, performing 3D sintering to metal powder by using a continuous laser or a pulse laser; step two, performing laser-induced shock wave impact to a 3D sintered component by using a short pulse width laser; step three, polishing the 3D sintered component obtained after the step two by using a continuous laser or a pulse laser. When the workpiece to be printed comprises powders of various materials, select a laser wavelength, pulse energy and pulse width according to an optical characteristic of the powder of each material, use the three steps to realize a printing of functionally graded materials. Compared with the prior art, the laser 3D printing system for metal workpiece could improve the occurrence of holes, over-burning and spheroidization phenomenon, thereby increasing the density of the metal workpiece.

Abstract: A laser 3D printing method with orthopedic function, comprising the following steps: step one, measuring a projection characteristic of each spot within a scanning plane, to obtain a deformation quantity of a focused light spot at the each spot within the scanning plane before rectifying; step two, setting compensation quantities of the each spot within the scanning plane of a light spot orthopedic device according to the measuring result of the step one, so that the size of the focused light spot at the each spot within the scanning plane is consistent; step three, turning on the laser, and dynamically matching the light spot orthopedic device and a scanning device to perform the laser 3D printing. The laser 3D printing method and system thereof with orthopedic function could ensure the size of the focused light spot is consistent within the scanning plane, thereby ensuring the quality of 3D printing.

Abstract: A multiple channel fiber pigtailed acousto-optic (AO) device comprises: a first multiple fiber collimator pigtail comprising a plurality of input fibers, a second multiple fiber collimator pigtail comprising a plurality of output fibers, wherein each of the plurality of output fibers is a conjugate of each of the plurality of input fibers, respectively, and an acousto-optic modulator (AOM) disposed between the first multiple fiber collimator pigtail and the second multiple fiber collimator pigtail, wherein the input fibers form input ports providing input beams to the AOM and the output fibers form output ports receiving output beams from the AOM, wherein at least one output fiber of the plurality of output fibers is coupled to an input fiber of the plurality of input fibers.

Abstract: A multiple channel fiber pigtailed acousto-optic (AO) device comprises: a first multiple fiber collimator pigtail comprising a plurality of input fibers, a second multiple fiber collimator pigtail comprising a plurality of output fibers, wherein each of the plurality of output fibers is a conjugate of each of the plurality of input fibers, respectively, and an acousto-optic modulator (AOM) disposed between the first multiple fiber collimator pigtail and the second multiple fiber collimator pigtail, wherein the input fibers form input ports providing input beams to the AOM and the output fibers form output ports receiving output beams from the AOM, wherein at least one output fiber of the plurality of output fibers is coupled to an input fiber of the plurality of input fibers.

Abstract: A multipass fiber amplifier comprises a micro-optic-module polarization separating device including a first ASE blocking device, a micro-optic-module 90° polarization rotating reflector including a second ASE blocking device, a pump source for providing pump light; a micro-optic-module wavelength-division multiplexer (WDM) for combining the pump light and the laser beam; and a gain fiber having a first end and a second end for amplifying the laser beam using the pump light, where the first ASE blocking device is coupled to the first end of the gain fiber and the second ASE blocking device is coupled to the second end of the gain fiber.

Abstract: A fiber coupled modular laser system comprises a laser oscillator, at least one fiber pre-amplifier, and at least one free space solid state power amplifier. The output of the laser oscillator is fiber coupled with the input of the at least one fiber pre-amplifier or the at least one free space solid state power amplifier. The output or the input of the at least one fiber pre-amplifier is fiber coupled with the input or the output of the at least one free space solid state power amplifier.

Abstract: A fiber laser oscillator comprises an active fiber for providing a lasing light having a selected wavelength band, a saturable absorber assembly coupled to a first end of the active fiber, a pump source for providing a pump light having wavelengths except the selected wavelength band, an optical component coupled to the second end of the active fiber and the pump source. The optical component comprises a thin film filter for transmitting the lasing light for a first time and reflecting the pump light and a reflector for reflecting the lasing light transmitted for the first time through the thin film filter. The lasing light reflected by the reflector transmits through the thin film filter for a second time and overlaps with the pump light reflected by the thin film filter.

Abstract: A multipass fiber amplifier comprises a micro-optic-module polarization separating device including a first ASE blocking device, a micro-optic-module 90° polarization rotating reflector including a second ASE blocking device, a pump source for providing pump light; a micro-optic-module wavelength-division multiplexer (WDM) for combining the pump light and the laser beam; and a gain fiber having a first end and a second end for amplifying the laser beam using the pump light, where the first ASE blocking device is coupled to the first end of the gain fiber and the second ASE blocking device is coupled to the second end of the gain fiber.

Abstract: An apparatus and method for multipass fiber amplifier comprises: (a) first passing a laser beam having a first linear polarization in the fiber amplifier in a first direction, (b) rotating the first linear polarization of the laser beam to a second linear polarization, the second linear polarization is perpendicular to the first linear polarization, (c) second passing the laser beam having the second linear polarization in the fiber amplifier in a second direction, the second direction is opposite to the first direction, (d) third passing the laser beam having the second linear polarization in the fiber amplifier in the first direction, the laser beam having the second linear polarization is reflected by a polarization separating device and a mirror, (e) rotating the second linear polarization of the laser beam to the first linear polarization, and (f) fourth passing the laser beam having the first linear polarization in the fiber amplifier in the second direction.

Abstract: A fiber coupled modular laser system comprises a laser oscillator, at least one fiber pre-amplifier, and at least one free space solid state power amplifier. The output of the laser oscillator is fiber coupled with the input of the at least one fiber pre-amplifier or the at least one free space solid state power amplifier. The output or the input of the at least one fiber pre-amplifier is fiber coupled with the input or the output of the at least one free space solid state power amplifier.

Abstract: An apparatus and method for multipass fiber amplifier comprises: (a) first passing a laser beam having a first linear polarization in the fiber amplifier in a first direction, (b) rotating the first linear polarization of the laser beam to a second linear polarization, the second linear polarization is perpendicular to the first linear polarization, (c) second passing the laser beam having the second linear polarization in the fiber amplifier in a second direction, the second direction is opposite to the first direction, (d) third passing the laser beam having the second linear polarization in the fiber amplifier in the first direction, the laser beam having the second linear polarization is reflected by a polarization separating device and a mirror, (e) rotating the second linear polarization of the laser beam to the first linear polarization, and (f) fourth passing the laser beam having the first linear polarization in the fiber amplifier in the second direction.

Abstract: Lasers are provided to deliver a wide variety of wavelengths at variable pulse energy. A laser cavity is formed between a first and second reflective surface. A lasing medium is located within cavity which lases at a preselected fundamental frequency. One or more nonlinear crystals are provided in optical communication with the lasing crystal to produce a secondary beam having a different frequency than the fundamental beam. A modulator is provided to control the pulse energy of the secondary beam. Desirably the secondary beam is a harmonic beam for example a second, third, fourth or fifth harmonic beam or a beam provided by an optical parametric oscillator.

Abstract: A laser beam includes a concave or convex mirror which is reflective for wavelength of the high intensity beam. The reflective mirror is located along a preselected path of a high intensity laser beam so that the high intensity laser beam intersects the mirror at a first position. A beam collimator is located in the path of the high intensity beam reflected by the concave or convex mirror. The concave or convex mirror is movably mounted desirably rotatably mounted in the path of the high intensity beam. Desirably the mirror is rotated about a preselected axis. Desirably, the axis is selected so that when the mirror is rotated to a new position, the high intensity beam will be reflected along the same path to the collimator as it was prior to any rotation.

Abstract: A matrix assisted laser desorption and ionization system is provided. The system includes a mass spectrometer for analyzing at least one sample. The mass spectrometer includes a sample receiving chamber for receiving a sample under a vacuum. A UV laser is provided for producing a UV beam along a first beam path that does not intersect with the sample. A beam expander is provided in optical communication with the UV laser beam to expand the diameter of the beam. A focusing system is provided in optical communication with the beam expander to focus the laser beam propagating from the beam expander to a predetermined minimum spot size. The focusing system is located along the path of the beam propagating from the beam expander so that the beam strikes the approximate optical center of the focusing system. A high reflecting mirror is provided in optical communication with the focused beam propagating from the focusing system to direct the focused beam to strike the sample at a preselected strike point.