Abstract: Given developing resistance of tumor cells to current chemotherapeutic and targeted therapeutic agents, novel cancer therapies with enhanced potency and specificity are substantially required. Applicant has provided herein extracellular nanoparticle vesicles that redirect immune effector cells towards cancer cells for killing. Relative to conventional immunotherapeutic antibodies with defined orientation and geometry for their distinct antigen-binding arms, antibodies displayed on spherical exosomes can promote formation of immunological synapses as well as enhanced efficacy to activate immune cells.

Abstract: Given developing resistance of tumor cells to current chemotherapeutic and targeted therapeutic agents, novel cancer therapies with enhanced potency and specificity are substantially required. Applicant has provided herein extracellular nanoparticle vesicles that redirect immune effector cells towards cancer cells for killing. Relative to conventional immunotherapeutic antibodies with defined orientation and geometry for their distinct antigen-binding arms, antibodies displayed on spherical exosomes can promote formation of immunological synapses as well as enhanced efficacy to activate immune cells.

Abstract: The present disclosure provides a DC concentrated illumination system, including a DC distribution box configured for converting a command specification that controls the state of lamps into a voltage signal with a varying amplitude, and outputting the voltage signal via a power line; and a plurality of lamp units, each includes a lamp, a power conversion unit and a simulated load unit, wherein the power conversion unit is coupled to the lamp and the simulated load unit, and is coupled to the DC distribution box via the power line. The power conversion unit receives the voltage signal and collects the state information of the lamps when the voltage signal matches a preset convention rule successfully; and the power conversion unit controls the action of the simulated load unit to get a current signal, the DC distribution box parses the current signal to obtain the state information of the lamps.

Abstract: A method and an apparatus for aggregating similar terms are provided by the embodiments of the present disclosure. The method includes extracting a plurality of candidate terms having a same term property from historical labeled data of network items; separately extracting associated terms that are adjacent to the candidate terms and have term properties associated therewith from the historical labeled data; and aggregating the plurality of candidate terms based on similarity degrees of the associated terms, and labeling thereof as synonyms. Based on the embodiments of the present disclosure, similar relationships among candidate terms can be mined, and classification of synonyms can be effectively performed for unstructured and non-standardized review terms related to electronic commerce.