Patents by Inventor Xiaojing Zheng

Xiaojing Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220326252
    Abstract: The present disclosure provides an improved method for accurately measuring the amino acid sequence of a therapeutic protein, in particular, an antibody, to insure the homogeneity of the protein such that it is suitable for administering to a human subject for treating a disease or disorder. The methods employ analytical physical chemistry techniques, in particular, a guided electron-transfer dissociation (ETD) and mass spectrometry (MS) approach for robust sequence coverage of the molecule with high accuracy and speed of use.
    Type: Application
    Filed: February 25, 2022
    Publication date: October 13, 2022
    Inventors: Xiaojing Zheng, Milos Cejkov, Tyler Greer, Reid O'Brien Johnson
  • Publication number: 20220216484
    Abstract: A fuel cell cathode catalyst layer structure for enhancing the durability of a catalyst is provided. The cathode catalyst layer structure includes a first catalyst portion, a second catalyst portion, and a third catalyst portion that are arranged in sequence from an area close to a diffusion layer to an area close to a proton exchange membrane (PEM); a pure platinum catalyst is placed inside the first catalyst portion, the second catalyst portion, and the third catalyst portion; platinum loads of the pure platinum catalysts inside the first catalyst portion, the second catalyst portion, and the third catalyst portion decrease progressively; and average particle sizes of pure platinum catalyst particles inside the first catalyst portion, the second catalyst portion, and the third catalyst portion increase progressively. The pure platinum catalyst with a large or small particle size is more resistant to corrosion, and improves the initial performance of fuel cell.
    Type: Application
    Filed: September 24, 2020
    Publication date: July 7, 2022
    Applicant: SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Junliang ZHANG, Zhifeng ZHENG, Fengjuan ZHU, Xiaojing CHENG, Guanghua WEI, Fan YANG, Guofeng XIA
  • Publication number: 20220074950
    Abstract: The present disclosure provides an improved method for profiling the nature of undesirable host cell proteins (HCPs) in a therapeutic antibody preparation using an improved assay. The assay includes three (3) exemplary steps comprising: ultra-low trypsin digestion, long gradient liquid chromatography, and mass spectrometry (MS) using, in particular, BoxCar mass spectrometry. The disclosure allows for determining the purity of a therapeutic antibody such that it is suitable for use in patients.
    Type: Application
    Filed: September 8, 2021
    Publication date: March 10, 2022
    Inventors: Song Nie, Tyler Greer, Reid O'Brien Johnson, Xiaojing Zheng, Ning Li
  • Publication number: 20220011318
    Abstract: The present disclosure provides a method for measuring post-translational modifications in proteins such as antibodies. In particular, the method may be used to quantify C-terminal truncation in antibodies that incorporates heavy isotopic standards for both the unprocessed C-terminal K peptide and the truncated C-terminal K peptide to build a calibration curve and quantify this PTM using mass spectrometry. Quantification of post-translational modifications may occur in a single liquid chromatography tandem mass spectrometry (LC-MS2) run.
    Type: Application
    Filed: June 18, 2021
    Publication date: January 13, 2022
    Inventors: Tyler Greer, Milos Cejkov, Reid O'Brien Johnson, Xiaojing Zheng, Ning Li
  • Publication number: 20210396764
    Abstract: The present disclosure provides a method for accurately measuring post-translational modifications in proteins such as antibodies. In particular, the method pertains to the use of heavy isotopic standards to generate a calibration curve to allow for accurate quantitation of a modified peptide. The method may be used to accurately quantify C-terminal truncation in antibodies using mass spectrometry.
    Type: Application
    Filed: June 18, 2021
    Publication date: December 23, 2021
    Inventors: Tyler Greer, Milos Cejkov, Reid O'Brien Johnson, Xiaojing Zheng, Ning Li
  • Publication number: 20210109107
    Abstract: Methods for characterizing host-cell proteins in a sample matrix are provided.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Inventors: Xiaojing Zheng, Reid O'Brien Johnson, Tyler Greer
  • Patent number: 10534677
    Abstract: Migrating applications executing on a storage system, including: detecting, by the storage system, that an application executing on a first platform within the storage system should be migrated to a second platform within the storage system; rejecting, by the storage system, all pending input/output (‘I/O’) requests received by the storage system from the application executing on the first platform; and initiating, by the storage system, execution of the application on the second platform.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: January 14, 2020
    Assignee: Pure Storage, Inc.
    Inventors: Jonathan Curley, Yuchen Jin, Christopher Lumb, Alexei Potashnik, Dilip Kumar Uppugandla, Christian Zankel, Xiaojing Zheng
  • Patent number: 10184152
    Abstract: Methods are provided herein for determining the likelihood that a subject, such as an asymptomatic subject, has chlamydial pelvic inflammatory disease. In some embodiments, the method can determine the likelihood that a pharmaceutical agent is effective for treating a subject that has chlamydial pelvic inflammatory disease. In other specific non-limiting examples, the method predicts endometritis and elevated pathogen burden. The subject is a female, such as a human female.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: January 22, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Catherine O'Connell, Toni Darville, Xiaojing Zheng
  • Publication number: 20180293017
    Abstract: Migrating applications executing on a storage system, including: detecting, by the storage system, that an application executing on a first platform within the storage system should be migrated to a second platform within the storage system; rejecting, by the storage system, all pending input/output (‘I/O’) requests received by the storage system from the application executing on the first platform; and initiating, by the storage system, execution of the application on the second platform.
    Type: Application
    Filed: March 1, 2018
    Publication date: October 11, 2018
    Inventors: JONATHAN CURLEY, YUCHEN JIN, CHRISTOPHER LUMB, ALEXEI POTASHNIK, DILIP KUMAR UPPUGANDLA, CHRISTIAN ZANKEL, XIAOJING ZHENG
  • Patent number: 9910618
    Abstract: Migrating applications executing on a storage system, including: detecting, by the storage system, that an application executing on a first platform within the storage system should be migrated to a second platform within the storage system; rejecting, by the storage system, all pending input/output (‘I/O’) requests received by the storage system from the application executing on the first platform; and initiating, by the storage system, execution of the application on the second platform.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: March 6, 2018
    Assignee: Pure Storage, Inc.
    Inventors: Jonathan Curley, Yuchen Jin, Christopher Lumb, Alexei Potashnik, Dilip Kumar Uppugandla, Christian Zankel, Xiaojing Zheng
  • Publication number: 20170183732
    Abstract: Methods are provided herein for determining the likelihood that a subject, such as an asymptomatic subject, has chlamydial pelvic inflammatory disease. In some embodiments, the method can determine the likelihood that a pharmaceutical agent is effective for treating a subject that has chlamydial pelvic inflammatory disease. In other specific non-limiting examples, the method predicts endometritis and elevated pathogen burden. The subject is a female, such as a human female.
    Type: Application
    Filed: April 16, 2015
    Publication date: June 29, 2017
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Catherine O'Connell, Toni Darville, Xiaojing Zheng
  • Patent number: 9500769
    Abstract: A monitoring system for turbulence of the atmospheric boundary layer under a wind drift sand flow environment includes: a meteorological tower, a hot-wire bracket and a plurality of observation frames, which are vertically and cooperatively arranged in parallel. The hot-wire bracket is arranged close to the meteorological tower, and the plurality of observation frames are symmetrically distributed on the two sides of a region formed by the meteorological tower and the hot-wire bracket. The meteorological tower is cooperatively provided thereon with a first group of experimental instruments for measurements; the hot-wire bracket is cooperatively provided thereon with a hot-wire probe assembly; and each observation frame is cooperatively provided thereon with a second group of experimental instruments for measurements.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: November 22, 2016
    Assignees: LANZHOU UNIVERSITY
    Inventors: Xiaojing Zheng, Tianli Bo, Yirui Liang, Jinghong Zhang, Guohua Wang
  • Patent number: 9244191
    Abstract: A real-time synchronous measurement system for multiple factors such as a wind-blown sand electric field, sand particle electrification and wind speed, comprising: a first support, a second support, a third support, and an electric field instrument disposed vertically in parallel. A 3D ultrasonic anemometer (4), a wind speed meter (3), a temperature and humidity detector (1), and a weather vane (2) are installed on and connected via data cables to the first support. A probe (7) of the electric field instrument is installed on the second support. A piezoelectric kinetic energy sensor (5) is installed on the third support. A data collector (6) is installed between and connected via data cables to the first support and the third support. A real-time sand particle mass-to-charge ratio instrument is further comprised. A computer (12) is installed between and connected via data cables to the second support and the real-time sand particle mass-to-charge ratio instrument.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: January 26, 2016
    Assignee: LANZHOU UNIVERSITY
    Inventors: Xiaojing Zheng, Tianli Bo, Yirui Liang
  • Publication number: 20150168600
    Abstract: A monitoring system for turbulence of the atmospheric boundary layer under a wind drift sand flow or sand dust storm environment comprises: a meteorological tower (6), a hot-wire bracket (9) and a plurality of observation frames (10), which are vertically and cooperatively arranged in parallel. The hot-wire bracket (9) is arranged close to the meteorological tower (6), and the plurality of observation frames (10) are symmetrically distributed on the two sides of a region formed by the meteorological tower (6) and the hot-wire bracket (9). The meteorological tower (6) is cooperatively provided thereon with a first group of experimental instruments for measurements; the hot-wire bracket (9) is cooperatively provided thereon with a hot-wire probe assembly (8); and each observation frame (10) is cooperatively provided thereon with a second group of experimental instruments for measurements.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 18, 2015
    Applicant: LANZHOU UNIVERSITY
    Inventors: Xiaojing Zheng, Tianli Bo, Yirui Liang, Jinghong Zhang, Guohua Wang
  • Publication number: 20140144227
    Abstract: A real-time synchronous measurement system for multiple factors such as a wind-blown sand electric field, sand particle electrification and wind speed, comprising: a first support, a second support, a third support, and an electric field instrument disposed vertically in parallel. A 3D ultrasonic anemometer (4), a wind speed meter (3), a temperature and humidity detector (1), and a weather vane (2) are installed on and connected via data cables to the first support. A probe (7) of the electric field instrument is installed on the second support. A piezoelectric kinetic energy sensor (5) is installed on the third support. A data collector (6) is installed between and connected via data cables to the first support and the third support. A real-time sand particle mass-to-charge ratio instrument is further comprised. A computer (12) is installed between and connected via data cables to the second support and the real-time sand particle mass-to-charge ratio instrument.
    Type: Application
    Filed: September 2, 2011
    Publication date: May 29, 2014
    Applicants: LANZHOU UNIVERSITY
    Inventors: Xiaojing Zheng, Tianli Bo, Yirui Liang
  • Patent number: 8573064
    Abstract: A magnetic suspension supporter for a direct tension test apparatus, includes an upper end cap and a lower end cap for fixing a sample, an upper chain and a lower chain connected to the upper and lower end caps respectively, an upper joint and a lower joint connected to the other ends of the upper and lower chains respectively, the lower joint being fixed to the test machine foundation. In addition, the upper and lower end caps, the upper and lower chains, the upper and lower joints as well as the supporter having a common vertical axis and being arranged in a cascade form, characterized in that a sample supporter is arranged between the lower end cap and the test machine foundation. The sample supporter is composed of a pair of upper magnet provided at the underside of the lower end cap and lower magnet on the upside of the test machine foundation, which constitute two magnets structure. The polarity directions of the two magnets are reversed and the same polarity is arranged oppositely on the axis.
    Type: Grant
    Filed: January 16, 2010
    Date of Patent: November 5, 2013
    Assignee: Lanzhou University
    Inventors: Zhonghu Zhao, Xiaojing Zheng, Youhe Zhou
  • Publication number: 20110259113
    Abstract: A magnetic suspension supporter for a direct tension test apparatus, includes an upper end cap and a lower end cap for fixing a sample, an upper chain and a lower chain connected to the upper and lower end caps respectively, an upper joint and a lower joint connected to the other ends of the upper and lower chains respectively, the lower joint being fixed to the test machine foundation. In addition, the upper and lower end caps, the upper and lower chains, the upper and lower joints as well as the supporter having a common vertical axis and being arranged in a cascade form, characterized in that a sample supporter is arranged between the lower end cap and the test machine foundation. The sample supporter is composed of a pair of upper magnet provided at the underside of the lower end cap and lower magnet on the upside of the test machine foundation, which constitute two magnets structure. The polarity directions of the two magnets are reversed and the same polarity is arranged oppositely on the axis.
    Type: Application
    Filed: January 16, 2010
    Publication date: October 27, 2011
    Applicant: LANZHOU UNIVERSITY
    Inventors: Zhonghu Zhao, Xiaojing Zheng, Youhe Zhou
  • Patent number: 7854011
    Abstract: A method of managing digital rights in a network without a central license server where each instance of the program broadcasts its identification into the network, and any instance of the program detecting its own license code from another node closes down. A closing program may also generate a close down message to the conflicting program.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: December 14, 2010
    Assignee: Green Packet, Inc.
    Inventors: Liangshen Chen, Xiaojing Zheng, Fan Du, Chen Hu
  • Patent number: 7620723
    Abstract: A system for discovering, identifying and managing ad hoc networks and facilitating the communications within that network is disclosed. An addition to the network interface mediates discovery of adjacent computers with the same addition running and the exchange of profiles between these computers to allow device sharing and routing.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: November 17, 2009
    Assignee: Green Packet, Inc.
    Inventors: Liangshen Chen, Xiaojing Zheng
  • Patent number: D912753
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: March 9, 2021
    Assignee: Jinhua Taisen Sports Goods Co., Ltd.
    Inventor: Xiaojing Zheng