Abstract: The present disclosure belongs to the technical field of heat exchangers, and provides a heat exchanger based on a Gyroid/Diamond (GD-type) hybrid minimal surface-based disturbance structure. The heat exchanger includes a core, headers, and flanges. The core includes a cold fluid channel and a hot fluid channel, the cold fluid channel and the hot fluid channel are separated by a parting sheet. An inlet and an outlet of the cold fluid channel are separated from an inlet and an outlet of the hot fluid channel by sealing bars. A GD-type hybrid minimal surface-based disturbance structure is inserted into the hot fluid channel. A cold fluid and a hot fluid are distributed in a cross-flow manner.

Abstract: The present disclosure belongs to the technical field of heat exchangers, and provides a heat exchanger based on a Gyroid/Diamond (GD-type) hybrid minimal surface-based disturbance structure. The heat exchanger includes a core, headers, and flanges. The core includes a cold fluid channel and a hot fluid channel, the cold fluid channel and the hot fluid channel are separated by a parting sheet. An inlet and an outlet of the cold fluid channel are separated from an inlet and an outlet of the hot fluid channel by sealing bars. A GD-type hybrid minimal surface-based disturbance structure is inserted into the hot fluid channel. A cold fluid and a hot fluid are distributed in a cross-flow manner.

Abstract: Embodiments of the present disclosure provide an ablation catheter, comprising: a catheter, a handle and a connector which are connected in sequence, wherein a plurality of electrodes are provided in sequence at a distal end of the catheter, each of the electrodes has a corresponding electrode lead, which passes through the catheter and the handle and is connected to the connector; the catheter comprises an insulated inner catheter, the electrodes are provided on the insulated inner catheter, an insulated outer catheter is provided between the plurality of electrodes, electrode leads of the plurality of electrodes are respectively provided between the insulated inner catheter and the insulated outer catheter.

Abstract: The present disclosure relates to a construction method for a prognostic model of hepatocellular carcinoma based on DNA damage repair (DDR) and immunogenic cell death (ICD) gene expression, including the following steps of: Step 1, acquiring transcription profile expression data of multiple hepatocellular carcinoma patients; step 2, screening candidate genes based on the transcription profile expression data of multiple hepatocellular carcinoma patients; step 3, determining prognostic genes related to lifetime through single-factor Cox regression analysis based on the candidate genes; step 4, screening the genes related to the lifetime through LASSO Cox regression analysis; and step 5, assessing the prediction performance of the risk score model based on the above training dataset.

Abstract: The present disclosure relates to a newly discovered tumor marker for hepatocellular carcinoma (HCC) and related applications thereof in clinical detection. The tumor marker for HCC in the present disclosure is OIT3, which is abnormally expressed at low levels in HCC tissues and can be used in the diagnosis and treatment of HCC. The present application further relates to primer sequences of OIT3 as an HCC marker, which can be used as a reagent for the detection and diagnosis of HCC. The present disclosure can improve the accuracy, efficiency, and diagnosis of early HCC and is suitable for popularization in the clinical diagnosis of HCC.

Abstract: The present application provides a quinolyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, as well as a method for preparing the compound, a use of the compound, and a formulation containing the quinolyl-substituted carboxylic acid compound or the pharmaceutically acceptable salt thereof. This type of compounds are inhibitors for AXL and/or VEGFR2 protein kinase, and can be used to treat diseases caused by abnormality of the two protein kinases, such as, tumor, etc.

Abstract: A method and system provides a near-field transducer (NFT) for a heat assisted magnetic recording (HAMR) transducer. The method and system include forming the disk of the NFT and forming the pin of the NFT. The disk is formed from a first material. The pin is formed from a second material different from the first material. The pin contacts the disk. At least a portion of the pin is between the disk and an air-bearing surface (ABS) location.

Abstract: The present application provides a quinolyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, as well as a method for preparing the compound, a use of the compound, and a formulation containing the quinolyl-substituted carboxylic acid compound or the pharmaceutically acceptable salt thereof. This type of compounds are inhibitors for AXL and/or VEGFR2 protein kinase, and can be used to treat diseases caused by abnormality of the two protein kinases, such as, tumor, etc.

Abstract: A method and system provides a near-field transducer (NFT) for a heat assisted magnetic recording (HAMR) transducer. The method and system include forming the disk of the NFT and forming the pin of the NFT. The disk is formed from a first material. The pin is formed from a second material different from the first material. The pin contacts the disk. At least a portion of the pin is between the disk and an air-bearing surface (ABS) location.

Abstract: A method and system provides a near-field transducer (NFT) for a heat assisted magnetic recording (HAMR) transducer. The method and system include forming the disk of the NFT and forming the pin of the NFT. The disk is formed from a first material. The pin is formed from a second material different from the first material. The pin contacts the disk. At least a portion of the pin is between the disk and an air-bearing surface (ABS) location.

Abstract: A soft magnetic nanocomposites (SMNC) which contains laminated thin flakes of magnetic materials coated with an insulating material wherein the thickness of the flake is from 100 nm to 20 ?m. The invention also relates to a process to make laminated thin flakes of magnetic materials.