Patents by Inventor Xiaoke WANG

Xiaoke WANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220337429
    Abstract: Disclosed are an interactive aggregate signature method, and a device and a storage medium, which relate to the technical field of data encryption. The method comprises: S101, generating a challenge number according to random numbers of all participating terminals, and respectively sending the random numbers corresponding to the participating terminals, the challenge number and a proposal message to corresponding participating terminals; S102, receiving a message from the participating terminals, and if partial signatures are included in the message, recording the partial signatures; S103, determining whether the number of recorded partial signatures reaches a number required for passing of the proposal message; if so, proceeding to S104, involving generating an aggregate signature by means of the partial signatures; and if not, outputting that the proposal message fails to be passed and an aggregate signature cannot be generated, or repeating steps S101 to S103.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Applicant: HANGZHOU QULIAN TECHNOLOGY CO., LTD.
    Inventors: Weiwei QIU, Wei LI, Kejie ZHANG, Fanglei HUANG, Xiaoke WANG
  • Patent number: 10894976
    Abstract: Disclosed here is a composition for isolating nucleic acids from a biological sample, comprising a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof. Also disclosed is a method for binding nucleic acids to a matrix, comprising: contacting the nucleic acids from a biological sample with the matrix in the presence of a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof, thereby binding the nucleic acids to the matrix. Further disclosed is a kit for isolating nucleic acids from a biological sample comprising a binding buffer, wherein the binding buffer comprises a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: January 19, 2021
    Assignee: Natera, Inc.
    Inventors: James Stray, Jason Tong, Xiaoke Wang
  • Patent number: 10845446
    Abstract: A system and method are provided for controlling a magnetic resonance imaging system to perform a gradient echo pulse sequence that includes varying a phase of an RF pulse of the gradient echo pulse sequence between repetitions and acquire complex MR data. The method includes processing the complex MR data to determine signal contributions from transverse relaxation (T2) in the subject, generating a quantitative T2 map of the subject using the signal contributions from T2 in the subject, and displaying the quantitative T2 map.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: November 24, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Scott B. Reeder, Xiaoke Wang
  • Publication number: 20200341090
    Abstract: A system and method are provided for controlling a magnetic resonance imaging system to perform a gradient echo pulse sequence that includes varying a phase of an RF pulse of the gradient echo pulse sequence between repetitions and acquire complex MR data. The method includes processing the complex MR data to determine signal contributions from transverse relaxation (T2) in the subject, generating a quantitative T2 map of the subject using the signal contributions from T2 in the subject, and displaying the quantitative T2 map.
    Type: Application
    Filed: April 24, 2019
    Publication date: October 29, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Scott B. Reeder, Xiaoke Wang
  • Patent number: 10261161
    Abstract: A phantom for use with magnetic resonance imaging (“MRI”) and, in particular, for calibrating quantitative diffusion MRI is provided. In general, the phantom includes a solution composed of a solvent that has diffusivity value higher than that of water, and a solute that when added to the solvent reduces the diffusivity of the solution. By varying the combined concentration of the solvent and solute, the diffusivity of the solution can be controlled to fall within a range of diffusivity values found in biological tissues in a variety of different physiological conditions or tissue environments.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xiaoke Wang, Scott Brian Reeder, Diego Hernando
  • Patent number: 10261152
    Abstract: A system and method are provided for determining B1 inhomogeneities or creating a T1 map of a subject using a magnetic resonance imaging (MRI) system that is corrected for an influence of a presence of fat and a presence of iron in the subject on T1 weighting. The method includes controlling the MRI system using a single pulse sequence to acquire, from the subject, a plurality of datasets with varied T1 weighting created by varying at least one of a repetition time (TR) and a flip angle (FA) for repetitions of the single pulse sequence. The method also includes using an MR signal model and the plurality of datasets, estimating B1 inhomogeneities or generating a T1 map of the subject that is corrected for an influence of a presence of fat and a presence of iron in the subject on T1 weighting in the plurality of datasets.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Scott B. Reeder, Xiaoke Wang, Diego Hernando
  • Publication number: 20180275235
    Abstract: A system and method are provided for determining B1 inhomogeneities or creating a T1 map of a subject using a magnetic resonance imaging (MRI) system that is corrected for an influence of a presence of fat and a presence of iron in the subject on T1 weighting. The method includes controlling the MRI system using a single pulse sequence to acquire, from the subject, a plurality of datasets with varied T1 weighting created by varying at least one of a repetition time (TR) and a flip angle (FA) for repetitions of the single pulse sequence. The method also includes using an MR signal model and the plurality of datasets, estimating B1 inhomogeneities or generating a T1 map of the subject that is corrected for an influence of a presence of fat and a presence of iron in the subject on T1 weighting in the plurality of datasets.
    Type: Application
    Filed: March 22, 2017
    Publication date: September 27, 2018
    Inventors: Scott B. Reeder, Xiaoke Wang, Diego Hernando
  • Publication number: 20180237841
    Abstract: Disclosed here is a composition for isolating nucleic acids from a biological sample, comprising a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof. Also disclosed is a method for binding nucleic acids to a matrix, comprising: contacting the nucleic acids from a biological sample with the matrix in the presence of a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof, thereby binding the nucleic acids to the matrix. Further disclosed is a kit for isolating nucleic acids from a biological sample comprising a binding buffer, wherein the binding buffer comprises a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof.
    Type: Application
    Filed: February 15, 2018
    Publication date: August 23, 2018
    Applicant: Natera, Inc.
    Inventors: James STRAY, Jason TONG, Xiaoke WANG
  • Publication number: 20160363644
    Abstract: A phantom for use with magnetic resonance imaging (“MRI”) and, in particular, for calibrating quantitative diffusion MRI is provided. In general, the phantom includes a solution composed of a solvent that has diffusivity value higher than that of water, and a solute that when added to the solvent reduces the diffusivity of the solution. By varying the combined concentration of the solvent and solute, the diffusivity of the solution can be controlled to fall within a range of diffusivity values found in biological tissues in a variety of different physiological conditions or tissue environments.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 15, 2016
    Inventors: Xiaoke WANG, Scott Brian REEDER, Diego HERNANDO