Patents by Inventor Xiaolan SUN

Xiaolan SUN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Humanized anti-TPBG antibody, preparation method therefor, conjugate thereof, and applications
    Patent number: 11608384
    Abstract: The present invention provides a humanized anti-TPBG antibody, a preparation method therefor, a conjugate thereof, and applications. The humanized anti-TPBG antibody comprises: (a), a framework region comprising a residue of a human antibody framework region; and (b) one or more CDRs of a light-chain variable region as shown in the SEQ ID NO:4 or 8 or one or more CDRs of a heavy-chain variable region as shown in the SEQ ID NO:2 or 6.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: March 21, 2023
    Assignee: XDCEXPLORER (SHANGHAI) CO., LTD.
    Inventors: Ying Zhang, Shiyong Gong, Xiaolan Sun, Tengjiao Xu, Fei Peng, Yuzhu Chen, Lile Liu
  • TPBG ANTIBODY AND PREPARATION METHOD THEREFOR, CONJUGATE AND USE THEREOF
    Publication number: 20210198377
    Abstract: The present invention provides a TPBG antibody, a preparation method thereof, conjugates and use thereof. The TPBG antibody comprises one or more of the heavy chain CDR1, the heavy chain CDR2 and the heavy chain CDR3 of the heavy chain variable region of TPBG antibody, and/or one or more of the light chain CDR1, the light chain CDR2 and the light chain CDR3 of the light chain variable region of TPBG antibody, and the amino acid sequences of which are described in the present invention. The TPBG antibody is humanized antibody with high affinity, and the conjugates prepared by coupling the TPBG antibody with the small-molecule drug toxin MMAF can have a cytotoxicity effects on TPBG-positive cells, therefore the TPBG antibody can be used in the preparation of drugs for treating tumors and the like.
    Type: Application
    Filed: December 23, 2016
    Publication date: July 1, 2021
    Applicant: XDCEXPLORER (SHANGHAI) CO., LTD.
    Inventors: Xiaolan SUN, Ying ZHANG, Yu ZHANG, Feifei HU, Shiyong GONG, Lile LIU
  • Anti-PD-L1 antibodies and uses thereof
    Patent number: 10889648
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 12, 2021
    Assignee: JIANGSU HYAMAB PHARMACEUTICAL CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Zhengrong Shuai, Hu Liu, Shaoping Hu, Xiaolan Sun, Hongzhuan Gu, Qing Duan, Tatchi Teddy Yang
  • Humanized Anti-TPBG Antibody, Preparation Method Therefor, Conjugate Thereof, and Applications
    Publication number: 20200062856
    Abstract: The present invention provides a humanized anti-TPBG antibody, a preparation method therefor, a conjugate thereof, and applications. The humanized anti-TPBG antibody comprises: (a), a framework region comprising a residue of a human antibody framework region; and (b) one or more CDRs of a light-chain variable region as shown in the SEQ ID NO:4 or 8 or one or more CDRs of a heavy-chain variable region as shown in the SEQ ID NO:2 or 6.
    Type: Application
    Filed: April 4, 2018
    Publication date: February 27, 2020
    Applicant: XDCEXPLORER (SHANGHAI) CO., LTD.
    Inventors: Ying Zhang, Shiyong Gong, Xiaolan Sun, Tengjiao Xu, Fei Peng, Yuzhu Chen, Lile Liu
  • ANTI-PD-L1 ANTIBODIES AND USES THEREOF
    Publication number: 20190010233
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Application
    Filed: December 27, 2016
    Publication date: January 10, 2019
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Zhengrong SHUAI, Hu LIU, Shaoping HU, Xiaolan SUN, Hongzhuan GU, Qing DUAN, Tatchi Teddy YANG