Abstract: A method for processing a cryptographic operation request includes receiving, at a hardware security module (HSM), the cryptographic operation request including a cryptographic key and at least one authorization token, determining, by the HSM, whether an access control list (ACL) associated with the cryptographic key of the cryptographic operation request is authorized to govern access to the cryptographic key, and validating, by the HSM, the at least one authorization token. When the at least one authorization token is valid and the ACL is authorized to govern access to the cryptographic key of the cryptographic operation request, the method includes processing, by the HSM, the cryptographic operation request.

Abstract: The method includes: generating an initial super-network structure in a super-network class according to a search space configuration file, and pre-training a super-network in the initial super-network structure by using a data set (S1); sampling a sub-network in the pre-trained super-network by using a controller, and setting corresponding head network and neck network in the sub-network according to a task type to form a sub-task network (S2); training the sub-task network, and updating the initial super-network structure according to a training result to obtain the super-network structure (S3); and verifying the super-network structure based on a plurality of sub-task networks, and optimizing the super-network and the controller by using verification results, and repeating the processes of the controller of sampling, verifying and optimizing until the time of repetitions reaches a threshold, and selecting the super-network structure with an optimal verification result as the search framework of the neural

Abstract: The invention provides methods for determining the activity of a plurality of nucleic acid regulatory elements. These methods may facilitate, e.g., the systematic reverse engineering, and optimization of mammalian cis-regulatory elements at high resolution and at a large scale. The method may include integration of multiplexed DNA synthesis and sequencing technologies to generate and quantify the transcriptional regulatory activity of e.g., thousands of arbitrary DNA sequences in parallel in cell-based as says (e.g., mammalian cell based assays).

Abstract: A method for processing a cryptographic operation request includes receiving, at a hardware security module (HSM), the cryptographic operation request including a cryptographic key and at least one authorization token, determining, by the HSM, whether an access control list (ACL) associated with the cryptographic key of the cryptographic operation request is authorized to govern access to the cryptographic key, and validating, by the HSM, the at least one authorization token. When the at least one authorization token is valid and the ACL is authorized to govern access to the cryptographic key of the cryptographic operation request, the method includes processing, by the HSM, the cryptographic operation request.

Abstract: A method for processing a cryptographic operation request includes receiving, at a hardware security module (HSM), the cryptographic operation request including a cryptographic key and at least one authorization token, determining, by the HSM, whether an access control list (ACL) associated with the cryptographic key of the cryptographic operation request is authorized to govern access to the cryptographic key, and validating, by the HSM, the at least one authorization token. When the at least one authorization token is valid and the ACL is authorized to govern access to the cryptographic key of the cryptographic operation request, the method includes processing, by the HSM, the cryptographic operation request.

Abstract: The present invention relates to a magnetic holder for immunoelectron microscopy grids. The holder comprises a frame, a magnet and a hydrophobic layer. The device can use a magnetic force to simultaneously attach the outer rings of nickel grids to the frame, so that a batch operation (such as rinsing, immunolabeling and dyeing) of the nickel grids can be realized. In addition, due to the hydrophobic effect of the hydrophobic layer, the holder can reduce the amount of the liquid carried by the nickel grids in the process of continuously transferring the nickel grids between different types of liquids to almost zero. Compared with the prior art, the magnetic holder effectively reduces the probability of cross-contamination between reagents.

Abstract: The present invention relates to a dual-arm clamping type holder for transmission electron microscopy grids and preparation method thereof. The preparation method comprises: firstly manufacturing a frame with two adjacent arms located on a same plane and have a clamping structure by a hard material; then putting the frame in a molten adhering liquid so that the frame is dipped with the adhering liquid; and finally, taking out the frame dipped with the adhering liquid, and waiting for the adhering liquid to solidify into adhering layers along the arms. The dual-arm clamping type holder manufactured by the method of the present invention comprises a frame and adhering layers; and the adhering layers adhere to the inner sides of the clamping structure between the two adjacent arms of the frame.

Abstract: The present invention relates to a magnetic holder for immunoelectron microscopy grids. The holder comprises a frame, a magnet and a hydrophobic layer. The device can use a magnetic force to simultaneously attach the outer rings of nickel grids to the frame, so that a batch operation (such as rinsing, immunolabeling and dyeing) of the nickel grids can be realized. In addition, due to the hydrophobic effect of the hydrophobic layer, the holder can reduce the amount of the liquid carried by the nickel grids in the process of continuously transferring the nickel grids between different types of liquids to almost zero. Compared with the prior art, the magnetic holder effectively reduces the probability of cross-contamination between reagents.

Abstract: The present invention relates to a dual-arm clamping type holder for transmission electron microscopy grids and preparation method thereof. The preparation method comprises: firstly manufacturing a frame with two adjacent arms located on a same plane and have a clamping structure by a hard material; then putting the frame in a molten adhering liquid so that the frame is dipped with the adhering liquid; and finally, taking out the frame dipped with the adhering liquid, and waiting for the adhering liquid to solidify into adhering layers along the arms. The dual-arm clamping type holder manufactured by the method of the present invention comprises a frame and adhering layers; and the adhering layers adhere to the inner sides of the clamping structure between the two adjacent arms of the frame.

Abstract: A method for processing a cryptographic operation request includes receiving, at a hardware security module (HSM), the cryptographic operation request including a cryptographic key and at least one authorization token, determining, by the HSM, whether an access control list (ACL) associated with the cryptographic key of the cryptographic operation request is authorized to govern access to the cryptographic key, and validating, by the HSM, the at least one authorization token. When the at least one authorization token is valid and the ACL is authorized to govern access to the cryptographic key of the cryptographic operation request, the method includes processing, by the HSM, the cryptographic operation request.

Abstract: Devices, systems, and methods for HFCWO oscillation therapy can enhance expectoration by preferred impact to the user to encourage mucus dislodging, including by successive pressure imposition to a chest engagement device to provide HFCWO.

Abstract: A method of checking file system compliance including receiving a plurality of compliance rules corresponding to a file system of a production system, collecting, by a collector, file system meta data from the file system, analyzing, by an analyzer, the file system meta data using the plurality of compliance rules to determine at least one compliance deviation of the file system, and throttling the collector and the analyzer independently of one-another, wherein the collector and the analyzer are configured according to a model of performance for the production system and a schedule for the collection and analyzing.

Abstract: A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.

Abstract: During a process of migrating a source system into a standardized virtual environment, virtual machine instances of the source system executing in a hypervisor are snapshotted as virtual machine images in an operational repository of the hypervisor. The virtual machine images in the operational repository are short-term snapshots. From time to time during the migration process, long-term snapshots of the source system are created by checking given ones of the virtual machine images from the hypervisor operational repository into an image library as image objects.

Abstract: An arbitrary customer instance is transferred from a customer environment to a target managed-infrastructure-as-a-service cloud environment as a transferred image. An image adjustment plan, capturing at least one adjustment required to render the transferred image compliant with standards of the target managed-infrastructure-as-a-service cloud environment, is formulated. The image adjustment plan is executed to adjust the transferred image to obtain an adjusted image compliant with standards of the target managed-infrastructure-as-a-service cloud environment. The adjusted image is on-boarded into the managed-infrastructure-as-a-service cloud environment as a standard image thereof.

Abstract: A method for processing a cryptographic operation request includes receiving, at a hardware security module (HSM), the cryptographic operation request including a cryptographic key and at least one authorization token, determining, by the HSM, whether an access control list (ACL) associated with the cryptographic key of the cryptographic operation request is authorized to govern access to the cryptographic key, and validating, by the HSM, the at least one authorization token. When the at least one authorization token is valid and the ACL is authorized to govern access to the cryptographic key of the cryptographic operation request, the method includes processing, by the HSM, the cryptographic operation request.

Abstract: A method and system for automating work pattern quantification and providing worker feedback based on quantified metrics is provided. The system may first identify a work pattern to be quantified for a user. Using one more predefined rules associated with the identified work pattern, the system determines at least one task associated with the work pattern. One or more services accessed to perform the associated task(s) are identified and event data from these services is collected, each event including an associated timestamp. The event data is analyzed to generate a focus metric(s). The generated focus metrics may then be used to quantify a work pattern by providing individual or group feedback.

Abstract: In an approach for detecting one or more applications in a VM, one or more processors establish a time duration. One or more processors detect two or more files, each file in the two or more files having a time stamp time that differs from a last modified time stamp time of at least one other file in the two or more files by no more than the time duration. One or more processors record an identifier for each file of the two or more files, a location, a name, and a last modified time stamp time of each file of the two or more files. One or more processors map the two or more files to an application installed on the VM.

Abstract: A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.

Abstract: A method of forming or creating a formulation for a compound to be delivered includes creating a carrier agent by conjugating at least one hydrophobic domain or hydrophobic compound with at least one hydrophilic domain or hydrophilic compound and associating the compound to be delivered with the carrier agent to create the formulation. The at least one hydrophobic compound has the formula: wherein R1 is a farnesyl group, a geranyl group or geranyl-geranyl group, X is O, S, SO, SO2, NH or Se, Z is C—R2 or N, R2 is H, CN, CO2R7, SO3R7, CONR7R8 or SO2NR7R8, wherein R7 and R8 are each independently H, an alkyl group, an alkenyl group, CO2M or SO3M, wherein M is a cation and R3, R4, and R5 are independently H, a carboxyl group, an alkyl group, an alkenyl group, an aminoalkyl group, a nitroalkyl group, a nitro group, a halo atom, an amino group, a mono-alkylamino group, a di-alkylamino group, mercapto group, a mercaptoalkyl group, an azido group or a thiocyanato group.