Patents by Inventor Xiaolei Li

Xiaolei Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260199490
    Abstract: Disclosed are compositions, systems, and methods for treating hyperopia and presbyopia without tissue removal to increase the refractive power of the cornea. A polymer conjugate is provided, which can be used as an injectable filler material for corneal implant. In particular embodiments, the polymer conjugate comprises an aldehyde hyaluronic acid conjugated with a poly ether through a —CH?N— bond.
    Type: Application
    Filed: December 8, 2023
    Publication date: July 16, 2026
    Inventors: Xiaolei Li, Conor L. Evans, Reginald Birngruber, Richard R. Anderson, Badri Parshad, Lara Buhl, Gabriela Apiou
  • Patent number: 12674936
    Abstract: A wavelength-division multiplexing device or a communications device may include a fastener, optical fibers, a filter, and a lens. The fastener is provided with an optical fiber positioning hole and a filter mounting groove, the filter mounting groove is disposed on a side of a tail end that is of the optical fiber positioning hole and that is away from an opening of the optical fiber positioning hole, and the filter mounting groove and the tail end of the optical fiber positioning hole are spaced apart. The optical fiber may be installed in the optical fiber positioning hole, the filter may be installed in the filter mounting groove, and the filter may transmissively transmit or reflect light rays emitted from the optical fiber.
    Type: Grant
    Filed: October 5, 2023
    Date of Patent: July 7, 2026
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Qiang Wang, Wenjie Zhuang, Xiaolei Li
  • Publication number: 20260151908
    Abstract: Disclosed is a multi-motion switching control method and system for a humanoid robot based on imitation learning, where the imitation learning is performed based on a Generative Adversarial Network, and a sampling probability for each motion skill is dynamically adjusted according to performance of the humanoid robot in executing the motion skill, so that the humanoid robot uniformly masters different motion skills; this enables the humanoid robot to integrate different combinations of motion skills, effectively mitigates the severity of the mode collapse problem, and provides good flexibility and scalability.
    Type: Application
    Filed: November 28, 2025
    Publication date: June 4, 2026
    Inventors: Ran SONG, Wei ZHANG, Honghao LIAO, Zhiheng LI, Wenhao TAN, Xing FANG, Xiaolei LI
  • Publication number: 20260132122
    Abstract: The present application provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 4 (CDK4), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: November 6, 2025
    Publication date: May 14, 2026
    Inventors: Liana Hie, Joshua Hummel, Xiaolei Li, Sharada Manns, Dibyendu Mondal, Shaoqun Qian, Xiaozhao Wang, Bo Wei, Ming Xiang
  • Patent number: 12626506
    Abstract: The present invention provides a method and system for detecting changes in areas, comprising: acquiring images at different times of an area by low-altitude UAVs; extracting state features for each of backbone feature pairs; analyzing importance of each of state parts due to the state parts have different importance degrees to the whole image features under different scenes; eliminating the state features from complete features by virtue of differences in importance degrees, to obtain corresponding essential parts; determining at least one change in the area by analyzing the essential parts. The invention comprehensively considers the importance of the state parts in the input images, and the essential parts contains complete and pure information are obtained, which reflects an actual changed region.
    Type: Grant
    Filed: December 17, 2024
    Date of Patent: May 12, 2026
    Assignee: SHANDONG UNIVERSITY
    Inventors: Runmin Cong, Zifeng Qiu, Wei Zhang, Ran Song, Liangbin Zhu, Yu Chen, Taoyi Chen, Xiaolei Li
  • Publication number: 20260125391
    Abstract: The present application provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 4 (CDK4), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: November 4, 2025
    Publication date: May 7, 2026
    Inventors: Peter Niels Carlson, Liana Hie, Joshua Hummel, Jacob J. Lacharity, Xiaolei Li, Sharada Manns, Eli Ortiz, Robert Susick, Xiaozhao Wang, Bo Wei
  • Publication number: 20260067518
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for content preprocessing. One of the methods includes determining, for a first set of digital content to be provided to a user device, (i) whether to establish network connections for obtaining data of the first set and (ii) a connection time indicating when to establish the network connections; establishing each of the network connections at the respective connection time; determining, for a previously stored set of digital content, (i) pre-processing operations for an item of the previously stored set of digital content and (ii) a pre-processing time indicating when to perform the pre-processing operations on the previously stored item; and providing one or more pre-processed items of the previously stored set of digital content to the user device.
    Type: Application
    Filed: September 4, 2025
    Publication date: March 5, 2026
    Inventors: Wei HE, Zhendong ZHONG, Aoyang ZHANG, Pengcheng CHEN, Shenglan HUANG, Qianpen WANG, Xiaolei LI, Chao MA, Mingkui LIU, Qian MA, Haiqing TAO, Baowang CHI
  • Patent number: 12536455
    Abstract: The present application discloses a method for early warning brandish of a transmission wire based on an improved Bayes-Adaboost algorithm, including: forming a classifier by training a historical brandish fault training set, and by using an Adaboost ensemble learning method, and obtaining an early warning result of the brandish of the transmission wire via the classifier according to real-time forecast meteorological information and information of different parameters of the transmission wire. The present invention can realize calculation and processing of forecast information of meteorological characteristic factors of the brandish of the transmission wire, structural parameters of the transmission wire and other related data, and obtain an early warning analysis result of a brandish disaster of the transmission wire in a region.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: January 27, 2026
    Assignees: State Grid Henan Electric Power Company Electric Power Science Research Institute, State Grid Henan Electric Power Company, State Grid Corporation of China
    Inventors: Degui Yao, Ning Zhou, Zhimin Guo, Lei Wang, Ming Lu, Zhe Li, Wei Zheng, Shanfeng Liu, Xiaolei Li, Jinyu Wang, Yun Liang, Chao Wang, Bo Zhang, Yupeng Zhang, Shaoguang Yuan, Yangyang Tian, Wandeng Mao, Xiaofei Zhang
  • Publication number: 20260001880
    Abstract: The present application provides bicyclic compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: June 25, 2025
    Publication date: January 1, 2026
    Inventors: Joshua Hummel, Liana Hie, Jacob J. Lacharity, Xiaolei Li, Xiaozhao Wang, Bo Wei, Sarah Winterton
  • Publication number: 20260003533
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for optimizing storage on a user device where an application for streaming video content is executed. Lifespans of videos stored on a disk of a device or in a memory of the device can be determined based on computed repeat probability rates for the videos. Weighted ratios for each of the videos can be computed as a ratio between a lifespan of the respective video and a duration of time for storage of the video on a) the disk or b) in memory. One or more video can be determined to be removed from the videos based on applying a deletion ratio over a sorted list of the videos. The sorted list is generated based on the computed weighted ratios.
    Type: Application
    Filed: June 27, 2025
    Publication date: January 1, 2026
    Inventors: Wei HE, Chong CHONG, Shenglan HUANG, Xiaolei LI, Haiqing TAO, Mingkui LIU, Qian MA
  • Patent number: 12510072
    Abstract: A compressor and a refrigeration device are provided. The compressor has a casing and a main frame disposed in the casing. The main frame has a guide structure configured to position the main frame. By coordination between the guide structure and a tooling, the process for positioning the main frame can be effectively simplified, the efficiency of positioning the main frame can be improved, and the assembly operation by workers can be facilitated.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: December 30, 2025
    Assignee: GUANGDONG MIDEA ENVIRONMENTAL TECHNOLOGIES CORPORATION LIMITED
    Inventors: Yuantie Zhao, Xiaolei Li, Bo Jiang, Xijin Huang, Junbo Liu, Canyu Qian, Baiying Huang
  • Patent number: 12491277
    Abstract: Disclosed is a multifunctional mobile digital radiography (DR) device. The multifunctional mobile DR device includes a rack, an X-ray detector, an image processor, a display, a handrail provided on the rack and a cleaning mechanism. The cleaning mechanism includes a guide assembly, a moving collar assembly and a first ultraviolet sterilization assembly. The guide assembly is adjacent to the handrail and extends from one end of the handrail to the other end of the handrail. The moving collar assembly is provided on the guide assembly and sleeved outside the handrail. The first ultraviolet sterilization assembly is provided on the moving collar assembly and configured to emit ultraviolet light and irradiate a peripheral of the handrail. The guide assembly is configured to guide the moving collar assembly and the moving collar assembly is configured to reciprocate between two ends of the handrail.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: December 9, 2025
    Assignee: Shenzhen Browiner Tech Co., Ltd
    Inventors: Xiaolei Li, Anshan Wang, Shufeng Li
  • Publication number: 20250255484
    Abstract: A device for carbon dioxide monitoring is disclosed. The device comprises: a photoluminescent carbon dioxide-sensitive probe comprising a polymer matrix and a sensing dye; a photon source configured to direct photons at the probe; a photodetector configured to detect light emitted from the probe when the photon source directs photons at the probe; a carbon dioxide permeable light redirection layer, wherein the carbon dioxide-sensitive probe is positioned between the light redirection layer and the photodetector; and a controller in electrical communication with the photon source and the photodetector, the controller being configured to execute a program stored in the controller to calculate a level of carbon dioxide adjacent the probe from an electrical signal received from the photodetector. In one form, the polymer matrix comprises a polymer selected from the group consisting of acrylate polymers, methacrylate polymers, polyurethane polymers, and blends and copolymers thereof.
    Type: Application
    Filed: April 17, 2023
    Publication date: August 14, 2025
    Inventors: Xiaolei Li, Juan Pedro Cascales Sandoval, Emmanouil Rousakis, Conor L. Evans
  • Patent number: 12372981
    Abstract: A method and a system for rhythmic motion control of a robot based on a neural oscillator, including: acquiring a current state of the robot, and a phase and a frequency generated by the neural oscillator; and obtaining a control instruction according to the acquired current state, phase and frequency and a preset reinforcement learning network so as to control the robot. The preset reinforcement learning network includes an action space, a pattern formation network and the neural oscillator. A control structure designed by the present disclosure, which is composed of the neural oscillator and the pattern formation network, can ensure formation of an expected rhythmic motion behavior; and meanwhile, a designed action space for joint position increment can effectively accelerate the training process of rhythmic motion reinforcement learning, and solve a problem that design of the reward function is time-consuming and difficult in learning with existing model-free reinforcement learning.
    Type: Grant
    Filed: October 18, 2022
    Date of Patent: July 29, 2025
    Assignee: SHANDONG UNIVERSITY
    Inventors: Wei Zhang, Yanyun Chen, Jiapeng Sheng, Xing Fang, Wenhao Tan, Ran Song, Xiaolei Li, Jiyu Cheng
  • Publication number: 20250186450
    Abstract: The present application provides methods of treating cancer using a combination of a DGK inhibitor and an inhibitor of PD-1 and/or PD-L1.
    Type: Application
    Filed: December 5, 2024
    Publication date: June 12, 2025
    Inventors: Xiaodi Ren, Rodrigo Hess, Joshua Hummel, Jacob J. Lacharity, Xiaolei Li, Sharada Manns, Ding-Quan Qian, Xiaozhao Wang, Bo Wei
  • Publication number: 20250179083
    Abstract: The present application provides tricyclic triazolo compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: December 4, 2024
    Publication date: June 5, 2025
    Inventors: Joshua Hummel, Liana Hie, Jacob J. Lacharity, Xiaolei Li, Ding-Quan Qian, Xiaozhao Wang, Bo Wei
  • Publication number: 20250135070
    Abstract: The present invention relates to a hyaluronic acid-based hydrogel precursor solution, a hyaluronic acid-based hydrogel, a preparation method and a repair material thereof. The hyaluronic acid-based hydrogel precursor solution includes a component A and a component B; the component A is prepared by the following steps: step S1, mixing methacrylate group-modified hyaluronic acid with furfuryl amine for reaction, to obtain furan-methacrylate modified hyaluronic acid; step S2, mixing the furan-methacrylate modified hyaluronic acid with maleimide for reaction, to obtain hyaluronic acid modified with dual groups; and step S3, mixing the hyaluronic acid modified with dual groups with a photoinitiator and a solvent, to obtain the component A; and the component B is a mercapto polyethylene glycol solution.
    Type: Application
    Filed: February 26, 2024
    Publication date: May 1, 2025
    Applicant: SUN YAT-SEN UNIVERSITY
    Inventors: Lin ZHUANG, Xiaolei LI, Wuming LIU
  • Publication number: 20250119480
    Abstract: In one embodiment, a method includes receiving a user request from a first user to create a reminder at a client system, wherein the user request does not specify an activation-condition for the reminder, determining proactive activation-conditions for the reminder, determining whether the proactive activation-conditions for the reminder are satisfied based on user context associated with the first user, and presenting the reminder to the first user at the client system responsive to determining the proactive activation-conditions are satisfied.
    Type: Application
    Filed: October 23, 2024
    Publication date: April 10, 2025
    Inventors: Piyush Khemka, Jivko Dobrev, Honglei Liu, Xiaolei Li
  • Publication number: 20250118068
    Abstract: The present invention provides a method and system for detecting changes in areas, comprising: acquiring images at different times of an area by low-altitude UAVs; extracting state features for each of backbone feature pairs; analyzing importance of each of state parts due to the state parts have different importance degrees to the whole image features under different scenes; eliminating the state features from complete features by virtue of differences in importance degrees, to obtain corresponding essential parts; determining at least one change in the area by analyzing the essential parts. The invention comprehensively considers the importance of the state parts in the input images, and the essential parts contains complete and pure information are obtained, which reflects an actual changed region.
    Type: Application
    Filed: December 17, 2024
    Publication date: April 10, 2025
    Applicant: SHANDONG UNIVERSITY
    Inventors: Runmin CONG, Zifeng QIU, Wei ZHANG, Ran SONG, Liangbin ZHU, Yu CHEN, Taoyi CHEN, Xiaolei LI
  • Publication number: 20250066363
    Abstract: The present application provides bicyclic compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.
    Type: Application
    Filed: August 23, 2024
    Publication date: February 27, 2025
    Inventors: Joshua Hummel, Liana Hie, Jacob J. Lacharity, Xiaolei Li, Ding-Quan Qian, Xiaozhao Wang, Bo Wei