Patents by Inventor Xiaoli LEI

Xiaoli LEI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING INTERMEDIATE OF ADRENERGIC RECEPTOR AGONIST
    Publication number: 20260085072
    Abstract: A method for preparing an intermediate of an adrenergic receptor agonist. The method comprises the following steps: cyclizing the compound of formula E1 or the compound of formula E2 and the compound of formula F0 to obtain the compound of formula C, where R1 is methyl, ethyl, isopropyl, propyl, tert-butyl, or butyl; R3 is H, Cl, F or Br; and L1 and L2 are each individually a leaving group. The method uses easily available raw materials, avoids the use of toxic and harmful reagents, is mild in terms of reaction conditions, is simple to operate, achieves a substantial improvement in yield and reduction in cost, and is more favorable for commercial production.
    Type: Application
    Filed: December 4, 2025
    Publication date: March 26, 2026
    Inventors: Wenqing LIN, Jianguo LI, Huan XU, Shikui LIU, Hongjie ZHENG, Xiaoli LEI, Jing ZHANG
  • Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
    Patent number: 11584745
    Abstract: Disclosed are an aromatic heterocyclic compound, an intermediate thereof, a preparation method therefor, and a pharmaceutical composition and use thereof. The aromatic heterocyclic compound of the present invention is a new ALK5 inhibitor, and is used for treating and/or preventing various ALK5-mediated diseases.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 21, 2023
    Assignee: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    Inventors: Zusheng Xu, Yangtong Lou, Li Chen, Kun Zeng, Qingrui Sun, Xiaoli Lei
  • Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
    Patent number: 11447490
    Abstract: Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin compound of the present invention is a novel ALK5 inhibitor and is for use in treating and/or preventing various ALK5-mediated diseases.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: September 20, 2022
    Assignee: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    Inventors: Zusheng Xu, Yangtong Lou, Li Chen, Kun Zeng, Qingrui Sun, Xiaoli Lei
  • AROMATIC HETEROCYCLIC COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20210032241
    Abstract: Disclosed are an aromatic heterocyclic compound, an intermediate thereof, a preparation method therefor, and a pharmaceutical composition and use thereof. The aromatic heterocyclic compound of the present invention is a new ALK5 inhibitor, and is used for treating and/or preventing various ALK5-mediated diseases.
    Type: Application
    Filed: December 28, 2018
    Publication date: February 4, 2021
    Applicant: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    Inventors: Zusheng XU, Yangtong LOU, Li CHEN, Kun ZENG, Qingrui SUN, Xiaoli LEI
  • AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF
    Publication number: 20210032242
    Abstract: Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin compound of the present invention is a novel ALK5 inhibitor and is for use in treating and/or preventing various ALK5-mediated diseases.
    Type: Application
    Filed: December 28, 2018
    Publication date: February 4, 2021
    Applicant: SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    Inventors: Zusheng XU, Yangtong LOU, Li CHEN, Kun ZENG, Qingrui SUN, Xiaoli LEI