Patents by Inventor Xiao-Li Tian

Xiao-Li Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Gene And Protein Associated With Angiogenesis And Endothelial Cell Specific Apoptosis
    Publication number: 20130058940
    Abstract: This invention provides isolated nucleic acid and amino acid sequences encoding VG5Q, a novel angiogenic growth factor protein with pro-angiogenic activity, a forkhead-associated domain, a G-patch domain; characteristic subcellular localization in an in vitro Matrigel model of angiogenesis: towards the cell periphery in early stages of tubulogenesis, between cells in newly formed endothelial tubes, and no nuclear staining after 24 hours; is expressed in endothelial cells; is secreted during angiogenesis; and interacts with TWEAK. The invention also provides for expression vectors containing nucleic acid sequences encoding VG5Q protein, and host cells containing one or more expression vectors for the recombinant expression of VG5Q. The invention also provides for methods of using VG5Q for the diagnosis and treatment of angiogenesis-mediated diseases or disorders.
    Type: Application
    Filed: May 21, 2012
    Publication date: March 7, 2013
    Applicant: The Cleveland Clinic Foundation
    Inventors: Qing K. Wang, Xiao-Li Tian, Rajkumar Kadaba
  • Gene and protein associated with angiogenesis and endothelial cell-specific apoptosis
    Patent number: 8207315
    Abstract: This invention provides isolated nucleic acid and amino acid sequences encoding VG5Q, a novel angiogenic growth factor protein with pro-angiogenic activity, a forkhead-associated domain, a G-patch domain; characteristic subcellular localization in an in vitro Matrigel model of angiogenesis: towards the cell periphery in early stages of tubulogenesis, between cells in newly formed endothelial tubes, and no nuclear staining after 24 hours; is expressed in endothelial cells; is secreted during angiogenesis; and interacts with TWEAK. The invention also provides for expression vectors containing nucleic acid sequences encoding VG5Q protein, and host cells containing one or more expression vectors for the recombinant expression of VG5Q. The invention also provides for methods of using VG5Q for the diagnosis and treatment of angiogenesis-mediated diseases or disorders.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: June 26, 2012
    Assignee: The Cleveland Clinic Foundation
    Inventors: Qing K. Wang, Xiao-Li Tian, Rajkumar Kadaba
  • Novel Gene and Protein Associated With Angiogenesis and Endothelial Cell-Specific Apoptosis
    Publication number: 20080199473
    Abstract: This invention provides isolated nucleic acid and amino acid sequences encoding VG5Q, a novel angiogenic growth factor protein with pro-angiogenic activity, a forkhead-associated domain, a G-patch domain; characteristic subcellular localization in an in vitro Matrigel model of angiogenesis: towards the cell periphery in early stages of tubulogenesis, between cells in newly formed endothelial tubes, and no nuclear staining after 24 hours; is expressed in endothelial cells; is secreted during angiogenesis; and interacts with TWEAK. The invention also provides for expression vectors containing nucleic acid sequences encoding VG5Q protein, and host cells containing one or more expression vectors for the recombinant expression of VG5Q. The invention also provides for methods of using VG5Q for the diagnosis and treatment of angiogenesis-mediated diseases or disorders.
    Type: Application
    Filed: August 20, 2004
    Publication date: August 21, 2008
    Applicant: Cleveland Clinic Foundation Innovations
    Inventors: Qing K. Wang, Xiao-Li Tian, Rajkumar Kadaba