Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: Provided is an aldehyde binder, specifically, disclosed is a compound as represented by formula (II) or a pharmaceutically acceptable salt.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a manual of joint and bone disorders such as arthritis and osteoporosis.

Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.

Abstract: The present disclosure provides a control method of a compressor and a refrigerant circulation system. The control method includes deciding whether a current working volume state of the compressor is matched with a control instruction after the compressor completes a change to a working volume according to the control instruction; determining that the compressor operates normally in a case where the current working volume state of the compressor is matched with the control instruction; and determining that the compressor operates in fault in a case where the current working volume state of the compressor is not matched with the control instruction.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Abstract: A switched mode power supply (SMPS) includes a filter (202), a power factor correction (PFC) circuit (204), and a control circuit (206, 406) configured to determine various electrical parameters of the SMPS. In some embodiments, the control circuit (206, 406) is configured to determine a power line frequency and an AC input voltage based on an AC line voltage and an AC neural voltage. In other embodiments, the control circuit (206, 406) is configured to determine an AC input current based on a reactive current flowing through the filter (202) and a PFC AC current. In further embodiments, the control circuit (206, 406) is configured to report a value of an electrical parameter if value is determined to be accurate. Other example switch mode power supplies, control circuits and methods are also disclosed.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Abstract: Disclosed are a compressor control method, control apparatus and control system. The method includes: receiving a cylinder switching instruction, and detecting operating parameters of a compressor; determining whether a cylinder switching operation is completed according to the operating parameters of the compressor; and after it is determined that the cylinder switching operation is completed, performing torque compensation.

Abstract: A switched mode power supply (SMPS) includes a filter (202), a power factor correction (PFC) circuit (204), and a control circuit (206, 406) configured to determine various electrical parameters of the SMPS. In some embodiments, the control circuit (206, 406) is configured to determine a power line frequency and an AC input voltage based on an AC line voltage and an AC neural voltage. In other embodiments, the control circuit (206, 406) is configured to determine an AC input current based on a reactive current flowing through the filter (202) and a PFC AC current. In further embodiments, the control circuit (206, 406) is configured to report a value of an electrical parameter if value is determined to be accurate. Other example switch mode power supplies, control circuits and methods are also disclosed.

Abstract: Embodiments of the present disclosure provide a method for controlling a fan, a system, and an air conditioner. The method includes: turning off a first bridge arm group in an inverter of the fan; applying a preset driving signal to a second bridge arm group in the inverter; detecting an electrical signal of a stator of the fan after the preset driving signal is applied; determining an initial state of the fan according to the electrical signal of the stator of the fan, wherein the initial state of the fan includes a downwind forward state, a static start state, or an unwind reverse state; and providing the fan with a control signal matching the initial state of the fan according to the initial state of the fan.

Abstract: A switched mode power supply (SMPS) includes a filter, a power factor correction (PFC) circuit, and a control circuit configured to determine various electrical parameters of the SMPS. In some embodiments, the control circuit is configured to determine a power line frequency and an AC input voltage based on an AC line voltage and an AC neural voltage. In other embodiments, the control circuit is configured to determine an AC input current based on a reactive current flowing through the filter and a PFC AC current. In further embodiments, the control circuit is configured to report a value of an electrical parameter if value is determined to be accurate. Other example switch mode power supplies, control circuits and methods are also disclosed.

Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.

Abstract: A switched mode power supply (SMPS) includes a filter, a power factor correction (PFC) circuit, and a control circuit configured to determine various electrical parameters of the SMPS. In some embodiments, the control circuit is configured to determine a power line frequency and an AC input voltage based on an AC line voltage and an AC neural voltage. In other embodiments, the control circuit is configured to determine an AC input current based on a reactive current flowing through the filter and a PFC AC current. In further embodiments, the control circuit is configured to report a value of an electrical parameter if value is determined to be accurate. Other example switch mode power supplies, control circuits and methods are also disclosed.

Abstract: The present disclosure provides a control method of a compressor and a refrigerant circulation system. The control method includes deciding whether a current working volume state of the compressor is matched with a control instruction after the compressor completes a change to a working volume according to the control instruction, determining that the compressor operates normally in a case where the current working volume state of the compressor is matched with the control instruction, and determining that the compressor operates in fault in a case where the current working volume state of the compressor is not matched with the control instruction.

Abstract: Disclosed are a compressor control method, control apparatus and control system. The method include: receiving a cylinder switching instruction, and detecting operating parameters of a compressor; determining whether a cylinder switching operation is completed according to the operating parameters of the compressor; and after it is determined that the cylinder switching operation is completed, performing torque compensation.

Abstract: The present invention provides a system and method for quickly determining a reasonable alarm threshold of a network, including: a presentation component for setting the template type and template parameter of an alarm simulation template, a generator for generating an alarm simulation task according to the alarm simulation template, a task component for executing the alarm simulation task to generate a data result set, and a storage component for storing and providing the data result set for the presentation component. The present invention adopts the asynchronous calculation, and adopts fragment manner during data statistics; the time period is divided into time slices and processed in parallel, and then aggregated, to improve the data processing rate; the similar alarm points are merged, thereby accurately obtaining the actual number of alarms and presenting in an incremental mode.