Patents by Inventor Xiaoling Ding
Xiaoling Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115713Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.Type: ApplicationFiled: July 21, 2021Publication date: April 11, 2024Inventors: Gaoquan LI, Nian LIU, Yongchen PENG, Xiafan ZENG, Gang MEI, Sheng GUAN, Yang GAO, Shuai YANG, Yifeng YIN, Jie LOU, Huiyu CHEN, Kun QIAN, Yusong WEI, Qian ZHANG, Dajun LI, Xiaoling DING, Xiangwei YANG, Liqun HUANG, Xi LIU, Liwei LIU, Zhenwei LI, Kaixiong HU, Hua LIU, Tao TU
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Patent number: 11813334Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.Type: GrantFiled: March 11, 2020Date of Patent: November 14, 2023Assignee: CHONGQING UPGRA BIOTECHNOLOGY CO., LTD.Inventors: Gaoquan Li, Dajun Li, Qian Zhang, Diedie Li, Chengzhi Gao, Yue Liu, Xiaoling Ding, Yusong Wei, Xiangwei Yang, Yongchen Peng, Jia Gao, Qiang Luo, Yanxia Heng, Mei Liu, Yuyang Yi, Xiafan Zeng, Tao Tu, Xiao Tang, Xi Liu, Jianhuan Li, Zhaojie Wang, Bin Wang, Jinping Wan, Mingyang Hou, Jiao Liu, Huiyu Chen, Jie Lou, Yue Yang, Yuanqiang Wang
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Publication number: 20230348671Abstract: A polyethylene glycol conjugate drug synergist, a preparation method therefor, and use thereof, specifically relating to a polyethylene glycol conjugate drug synergist as shown in formula I or a pharmaceutically acceptable salt thereof, a preparation method for the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylent glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, a composition containing the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof in preparation of a drug.Type: ApplicationFiled: July 21, 2021Publication date: November 2, 2023Inventors: Gaoquan LI, Nian LIU, Xiafan ZENG, Yongchen PENG, Gang MEI, Shuai YANG, Yang GAO, Sheng GUAN, Yifeng YIN, Huiyu CHEN, Jie LOU, Kun QIAN, Xiangwei YANG, Liwei LIU, Zhenwei LI, Kaixiong HU, Hua LIU, Qian ZHANG, Dajun LI, Yusong WEI, Xiaoling DING, Xi LIU, Liqun HUANG, Tao TU
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Patent number: 11793881Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.Type: GrantFiled: November 18, 2020Date of Patent: October 24, 2023Assignee: CHONGQING UPGRA BIOTECHNOLOGY CO., LTD.Inventors: Gaoquan Li, Dajun Li, Qian Zhang, Yusong Wei, Yongchen Peng, Xiangwei Yang, Xiafan Zeng, Gang Mei, Diedie Li, Chengzhi Gao, Xiaoling Ding, Yue Liu, Jia Gao, Yuyang Yi, Yanxia Heng, Xi Liu, Tao Tu, Kai Wang, Liwei Liu, Mei Liu, Qiang Luo, Xiao Tang, Jie Lou, Huiyu Chen, Yue Yang, Yuanqiang Wang
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Publication number: 20230101564Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.Type: ApplicationFiled: March 11, 2020Publication date: March 30, 2023Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Diedie LI, Chengzhi GAO, Yue LIU, Xiaoling DING, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jia GAO, Qiang LUO, Yanxia HENG, Mei LIU, Yuyang YI, Xiafan ZENG, Tao TU, Xiao TANG, Xi LIU, Jianhuan LI, Zhaojie WANG, Bin WANG, Jinping WAN, Mingyang HOU, Jiao LIU, Huiyu CHEN, Jie LOU, Yue YANG, Yuanqiang WANG
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Publication number: 20230088403Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.Type: ApplicationFiled: November 18, 2020Publication date: March 23, 2023Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Yusong WEI, Yongchen PENG, Xiangwei YANG, Xiafan ZENG, Gang MEI, Diedie LI, Chengzhi GAO, Xiaoling DING, Yue LIU, Jia GAO, Yuyang Yi, Yanxia HENG, Xi LIU, Tao TU, Kai WANG, Liwei LIU, Mei LIU, Qiang LUO, Xiao TANG, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
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Publication number: 20230073036Abstract: The disclosure relates to the technical field of medicine, specifically to a polyethylene glycol conjugated drug, a preparation method therefor and use thereof, and relates in particular to a polyethylene glycol conjugated drug represented by formula (I) or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.Type: ApplicationFiled: March 11, 2020Publication date: March 9, 2023Inventors: Gaoquan LI, Qian ZHANG, Dajun LI, Diedie LI, Chengzhi GAO, Xiaoling DING, Yue LIU, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jia GAO, Qiang LUO, Yanxia HENG, Mei LIU, Yuyang YI, Xiafan ZENG, Tao TU, Xiao TANG, Xi LIU, Jianhuan LI, Zhaojie WANG, Jinping WAN, Mingyang HOU, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
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Publication number: 20230042006Abstract: The present disclosure belongs to the field of livestock molecular biotechnology, and provides kits and methods for pedigree division and paternity testing of domestic pigs. The kits and methods specifically select 14 SSR loci of domestic pigs, especially Anqing six-end-white pigs, and synthesize primers for corresponding loci. Through capillary electrophoresis detection of the ear tissue DNA of 98 Anqing six-end-white pigs, the count of effective alleles, heterozygosity, polymorphism information content, and genetic distance, and exclusion probability at each locus are calculated, the pedigree division of domestic pigs, especially Anqing six-end-white pigs, and paternity testing are conducted. The cumulative exclusion probability of 14 microsatellite loci is 99%.Type: ApplicationFiled: July 11, 2022Publication date: February 9, 2023Applicant: ANHUI AGRICULTURAL UNIVERSITYInventors: Yueyun DING, Xiaoling DING, Zongjun YIN, Xudong WU, Xiaodong ZHANG, Xianrui ZHENG, Zijing LING, Qiong CHEN, Yinhui HOU, Chengcheng KONG
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Publication number: 20220105189Abstract: The disclosure relates to the technical field of medicine and in particular to a polyethylene glycol conjugated drug of formula I or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation and an intermediate of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.Type: ApplicationFiled: June 3, 2019Publication date: April 7, 2022Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Xiaoling DING, Diedie LI, Lei HUANG, Jinping WAN, Yue LIU, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jiao LIU, Jianhuan LI, Qiang LUO, Xi LIU, Bin WANG, Hui GONG, Yu CHEN, Yunjie JIANG, Zhongquan LIU, Kun XU, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
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Publication number: 20180270430Abstract: A pixel circuit, a semiconductor camera detection circuit and a display device. The pixel circuit includes: a photodiode, a driving circuit, an initialization circuit, a transmission circuit, a voltage write-in circuit (2 and a compensation circuit. One end of the photodiode is electrically connected to a grounding end, and another end is electrically connected to the transmission circuit; the initialization circuit is configured to pull a voltage of a first node to an initialization voltage under control of the initialization signal end; the transmission circuit is configured to pull down the voltage of the first node from the initialization voltage to a data voltage under control of the first scanning signal end; the voltage write-in circuit is configured to write the data voltage into the driving circuit and output a grounding voltage to the compensation circuit; the compensation circuit is configured to perform threshold voltage compensation on the driving circuit.Type: ApplicationFiled: April 28, 2017Publication date: September 20, 2018Inventors: Shengji Yang, Xue Dong, Hailin XUE, Xiaochuan Chen, Haisheng WANG, Lei WANG, Yingming LIU, Xiaoling DING, Ming YANG
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Patent number: 8501338Abstract: A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.Type: GrantFiled: April 20, 2011Date of Patent: August 6, 2013Assignee: University of South FloridaInventors: Andres M. Cardenas-Valencia, Norma A. Alcantar, Xiaoling Ding, Ryan G. Toomey, Lawrence C. Langebrake
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Patent number: 8163418Abstract: A system and method for improving electrochemical power sources through the dispensing, encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.Type: GrantFiled: November 11, 2008Date of Patent: April 24, 2012Assignee: University of South FloridaInventors: Andres M. Cardenas-Valencia, Norma A. Alcantar, Xiaoling Ding, Ryan G. Toomey, Lawrence C. Langebrake
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Patent number: 7943259Abstract: A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.Type: GrantFiled: December 18, 2007Date of Patent: May 17, 2011Assignee: University of South FloridaInventors: Andres M. Cardenas-Valencia, Norma Alcantar, Xiaoling Ding, Ryan G. Toomey, Larry Langebrake
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Patent number: 7923072Abstract: A method for the formation of regular-shaped silver crystals through a wet chemical reaction (Tollen's reaction) is presented. The growth of the Ag crystals (size, morphology and aggregation) can be controlled via adjusting reaction conditions such as temperature and reducing agent concentrations before and during the reactions. The smaller Ag crystals (50-200 nm) were generated under the condition of limited reductive reagent (glucose), and the larger sliver crystals (˜5 ?m) were the aggregated silver nano-particles (100-200 nm) produced at higher reducing agent concentrations. Most of the larger crystals were in the shape of cube or rectangular cube, and rarely, they were in clusters. The smaller crystals (aggregation of Ag atoms) were shaped in cube or/and cone, and both single crystals and clusters were formed. The presence of impurity (TiO2 nano-particles, 25-50 nm) as crystal seeds enables the 3-D growth of large, irregular-shaped Ag clusters (˜5 ?m).Type: GrantFiled: January 14, 2005Date of Patent: April 12, 2011Assignee: University of South FloridaInventors: Xiaoling Ding, David Fries
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Patent number: 7829034Abstract: The instant invention provides for a gas purification system in which a reaction chamber combines with catalysts and heating to oxidize and reduce the compounds contained in a gas stream to oxygen and other non-deleterious components. By use of this system closed loop air systems can be effectively supplied with oxygen by chemically converting the volatile organic components to desired gasses and thereby remove unwanted contaminants.Type: GrantFiled: July 7, 2005Date of Patent: November 9, 2010Assignee: University of South FloridaInventor: Xiaoling Ding
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Patent number: 7622239Abstract: A method for making a patterned SiO2 films over TiO2 (Si02/Ti02) under ambient atmospheric conditions, including room temperature, through photo and chemical reactions. The method is simple, convenient and can be performed in a short period of time, typically less than two hours. The patterned TiO2 film is fabricated through photo-irradiation of a photosensitive organic-titanium film using a mask. Silica particles are generated from silicate solution by adjusting pH values to 10 to 8 with hydrochloric acid. The pre-deposited TiO2 film has a strong attraction for the SiO2 particles, leading to the instant formation of SiO2 film over the TiO2 film. The silica films are also amino-silylated with 3-aminopropyltriethoxysilane toward applications such as patternable, location-specific silica-based separation and purification.Type: GrantFiled: October 10, 2006Date of Patent: November 24, 2009Assignee: University of South FloridaInventors: Xiaoling Ding, David P. Fries
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Publication number: 20070184358Abstract: A method for making a patterned SiO2 films over TiO2 (SiO2/TiO2) under ambient atmospheric conditions, including room temperature, through photo and chemical reactions. The method is simple, convenient and can be performed in a short period of time, typically less than two hours. The patterned TiO2 film is fabricated through photo-irradiation of a photosensitive organic-titanium film using a mask. Silica particles are generated from silicate solution by adjusting pH values to 10 to 8 with hydrochloric acid. The pre-deposited TiO2 film has a strong attraction for the SiO2 particles, leading to the instant formation of SiO2 film over the TiO2 film. The silica films are also amino-silylated with 3-aminopropyltriethoxysilane toward applications such as patternable, location-specific silica-based separation and purification.Type: ApplicationFiled: October 10, 2006Publication date: August 9, 2007Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: Xiaoling Ding, David Fries
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Publication number: 20070009414Abstract: The instant invention provides for a gas purification system in which a reaction chamber combines with catalysts and heating to oxidize and reduce the compounds contained in a gas stream to oxygen and other non-deleterious components. By use of this system closed loop air systems can be effectively supplied with oxygen by chemically converting the volatile organic components to desired gasses and thereby remove unwanted contaminants.Type: ApplicationFiled: July 7, 2005Publication date: January 11, 2007Applicant: UNIVERSITY OF SOUTH FLORIDAInventor: Xiaoling Ding
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Publication number: 20050229747Abstract: A method for the formation of regular-shaped silver crystals through a wet chemical reaction (Tollen's reaction) is presented. The growth of the Ag crystals (size, morphology and aggregation) can be controlled via adjusting reaction conditions such as temperature and reducing agent concentrations before and during the reactions. The smaller Ag crystals (50-200 nm) were generated under the condition of limited reductive reagent (glucose), and the larger sliver crystals (˜5 ?m) were the aggregated silver nano-particles (100-200 nm) produced at higher reducing agent concentrations. Most of the larger crystals were in the shape of cube or rectangular cube, and rarely, they were in clusters. The smaller crystals (aggregation of Ag atoms) were shaped in cube or/and cone, and both single crystals and clusters were formed. The presence of impurity (TiO2 nano-particles, 25-50 nm) as crystal seeds enables the 3-D growth of large, irregular-shaped Ag clusters (˜5 ?m).Type: ApplicationFiled: January 14, 2005Publication date: October 20, 2005Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: Xiaoling Ding, David Fries