Abstract: A method for denoising click data includes: acquiring a set of click data including pieces of first click data and a real label corresponding to each piece of first click data; extracting feature vectors of each piece of first click data with a graph model; dividing the feature vectors into sets of feature vectors; obtaining trained binary classification models by training binary classification models with the sets of feature vectors; for each of the feature vectors, obtaining prediction values corresponding to the feature vector by predicting the feature vector with the trained binary classification models, and calculating a prediction label of the feature vector based on the prediction values of the feature vector; and removing noise data in the pieces of first click data, based on the pieces of first click data, the real label and the prediction label of each piece of first click data.

Abstract: Disclosed are an aroyl substituted tricyclic compound, a preparation method therefor and use thereof. Specifically, the aroyl substituted tricyclic compound of the present invention has a structure of formula (C), and has, as a BTK inhibitor, the advantages of high activity, good selectivity and low toxic and side effects.

Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.

Abstract: The invention discloses a solid dispersion, a pharmaceutical preparation, a preparation method and an application thereof. The solid dispersion of the invention comprises carriers and active constituents, which is a compound as shown in formula (I) and/or a pharmaceutically acceptable salt thereof; The carrier is “homopolymer and copolymer of N-vinyl lactam” and/or pH-dependent cellulose derivatives. The preparation of the invention comprises the solid dispersion, fillers and disintegrating agents. The solid dispersion of the invention has good dissolution and significantly improves the solubility of effective constituents. The preparation can effectively improve the bioavailability of Bcl-2 inhibitor, has good dissolution and stability, and can improve the safety of a medication.

Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.

Abstract: The present invention belongs to the field of forest ecological culture and discloses a method for improving the survival rate of a directly-planted seedling and a transplanting seedling of a haloxylon plant in desert or semi-desert environment. In desert and semi-desert areas meeting a certain condition, the base part of the stem of the directly-planted seedling or the transplanting seedling of the haloxylon plant is protected by using a cylindrical pipe or hollow bullet-shaped pipe of a certain specification from damage or even death caused by stress factors such as a ground surface layer at high temperature. Through the present invention, the survival rate of a directly-planted seedling and a transplanting seedling of the haloxylon plant under extremely stress conditions in the desert and semi-desert areas can be obviously improved, and the average improvement rate is over 50%, the quick growth and development of individuals are promoted and the annual mass growth is increased.

Abstract: The present invention belongs to the field of forest ecological culture and discloses a method for improving the survival rate of a directly-planted seedling and a transplanting seedling of a haloxylon plant in desert or semi-desert environment. In desert and semi-desert areas meeting a certain condition, the base part of the stem of the directly-planted seedling or the transplanting seedling of the haloxylon plant is protected by using a cylindrical pipe or hollow bullet-shaped pipe of a certain specification from damage or even death caused by stress factors such as a ground surface layer at high temperature. Through the present invention, the survival rate of a directly-planted seedling and a transplanting seedling of the haloxylon plant under extremely stress conditions in the desert and semi-desert areas can be obviously improved, and the average improvement rate is over 50%, the quick growth and development of individuals are promoted and the annual mass growth is increased.