Patents by Inventor Xiaoling Li

Xiaoling Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210205226
    Abstract: The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
    Type: Application
    Filed: March 10, 2021
    Publication date: July 8, 2021
    Inventor: Xiaoling LI
  • Publication number: 20210196638
    Abstract: The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.
    Type: Application
    Filed: March 5, 2021
    Publication date: July 1, 2021
    Inventors: Feihuang DENG, Xin LIU, Yu ZHENG, Jie CHENG, Senping CHENG, Xiaoling LI
  • Publication number: 20210178677
    Abstract: The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology.
    Type: Application
    Filed: February 19, 2021
    Publication date: June 17, 2021
    Inventors: Haili LIU, Feihuang DENG, Wei WU, Renjie LI, Senping CHENG, Xiaoling LI
  • Publication number: 20210154910
    Abstract: A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the nozzle (131).
    Type: Application
    Filed: May 11, 2018
    Publication date: May 27, 2021
    Inventors: Senping CHENG, Xiaoling LI, Feihuang DENG, Haohui LU, Haili LIU, Juan YAO, Xiaofei WANG, Wei WU
  • Publication number: 20210128479
    Abstract: A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active pharmaceutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.
    Type: Application
    Filed: January 25, 2018
    Publication date: May 6, 2021
    Inventors: Senping CHENG, Xiaoling LI, Feihuang DENG, Juan YAO
  • Publication number: 20210127712
    Abstract: Disclosed are Lactobacillus rhamnosus strain 753 and uses thereof, a silage additive and silage. Lactobacillus rhamnosus strain 753 is deposited in China General Microbiological Culture Collection Center with an accession number of CGMCC 18233. Lactobacillus rhamnosus strain 753 can improve the quality of silage in a high-temperature and high-humidity region, and the silage processed by Lactobacillus rhamnosus strain 753 has good stability and low pH, low aflatoxin B1 content and less dry matter loss. In addition, secondary fermentation can be avoided in the silage processed by Lactobacillus rhamnosus strain 753 when a silo or bale for silage is opened.
    Type: Application
    Filed: October 31, 2020
    Publication date: May 6, 2021
    Applicant: SICHUAN AGRICULTURAL UNIVERSITY
    Inventors: Xinquan ZHANG, Hao GUAN, Yanhong YAN, Yang SHUAI, Xiaoling LI, Qifan RAN, Gang NIE, Xia WANG, Ting HUANG, Dandan LI, Zhongfu YANG, Xiao MA, Linkai HUANG
  • Patent number: 10973767
    Abstract: The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: April 13, 2021
    Assignee: Triastek, Inc.
    Inventor: Xiaoling Li
  • Publication number: 20210078244
    Abstract: In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or areagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.
    Type: Application
    Filed: December 25, 2018
    Publication date: March 18, 2021
    Inventors: Feihuang DENG, Xiaoling LI, Senping CHENG
  • Publication number: 20210077410
    Abstract: The present disclosure provides oral drug dosage forms comprising: (a) an erodible non-stimulant material admixed with an ADHD non-stimulant; and (b) an erodible stimulant material admixed with an ADHD stimulant, wherein the erodible non-stimulant material admixed with the ADHD non-stimulant is embedded in a substrate material, and wherein upon exposure to gastrointestinal fluid the ADHD non-stimulant is released according to a desired non-stimulant release profile and the ADHD stimulant is released according to a desired stimulant release profile. In some embodiment, the ADHD non-stimulant is released according to a sustained release profile. In some embodiments, the ADHD stimulant is released according to an immediate release profile. The oral drug dosage forms of the present disclosure are useful for the treatment of attention deficit hyperactivity disorder (ADHD). Also provided herein are methods of designing and manufacturing the oral drug dosage forms described herein.
    Type: Application
    Filed: December 25, 2018
    Publication date: March 18, 2021
    Inventors: Feihuang DENG, Xiaoling LI, Senping CHENG, Ying WANG, Qing LUO
  • Patent number: 10890388
    Abstract: A method of manufacturing a tube is provided. The method includes: selecting a core pipe having a thickness that is initially less than a desired thickness of the tube; and building-up an outer layer over an exterior surface of the core pipe via additive manufacturing so as to increase the thickness of the core pipe such that the thickness of the core pipe is equal to the desired thickness of the tube.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: January 12, 2021
    Assignee: GENERAL ELECTRIC TECHNOLOGY GMBH
    Inventors: Ronald Francis Konopacki, Philip Frederick Gilston, Xiaoling Li
  • Publication number: 20200338009
    Abstract: Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 29, 2020
    Inventors: Xiaoling LI, Haohui LU, Wei WU, Haili LIU, Senping CHENG, Renjie LI, Yang LIU, Feihuang DENG
  • Publication number: 20200315971
    Abstract: The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Inventor: Xiaoling LI
  • Patent number: 10684410
    Abstract: A liquid crystal display and a backlight module thereof are provided. The backlight module includes a backlight source and a light guide plate. The backlight source is disposed at a side surface of the light guide plate. The light guide plate has an accommodation section for accommodating a functional module. The backlight module includes a compensation light source that is disposed on the light guide plate. The accommodation section is located between the backlight source and the compensation light source. The backlight module includes a compensation light source, and the backlight source and the compensation light source are located at two opposite sides of the accommodation section. The compensation light source may compensate for the illumination light in the light guide plate blocked by the functional module, so as to solve the non-uniform display problem of blocking the illumination light from the backlight source by the functional module.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 16, 2020
    Assignee: WUHAN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventor: Xiaoling Li
  • Patent number: 10624857
    Abstract: Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 21, 2020
    Assignee: Triastek, Inc.
    Inventors: Xiaoling Li, Haohui Lu, Wei Wu, Haili Liu, Senping Cheng
  • Patent number: 10604466
    Abstract: The present invention provides a method for preparing a resveratrol compound, and belongs to the technical field of organic synthesis. In the present invention, first alkoxy-substituted benzyl halide, alkoxy-substituted benzaldehyde and a metal catalyst are subjected to oxidative addition and reduction elimination reactions to obtain alkoxy-substituted diphenylethanone; and then the alkoxy-substituted diphenylethanone and a metal catalyst are subjected to reduction, trans elimination and selective debenzylation reactions under a hydrogen atmosphere to obtain the resveratrol compound. In the preparation method of the present invention, the hydrogenation reduction, trans elimination and selective debenzylation reactions can be achieved just by a one-pot process, where the reaction directly obtains a trans olefin, thereby avoiding the formation of a isomer; and also the reaction selectively catalyzes debenzylation to eliminate Lewis acids from the source, and has the advantage of a high yield.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: March 31, 2020
    Assignees: HANGZHOU NORMAL UNIVERSITY, GREAT FOREST BIOMEDICAL LTD.
    Inventors: Weiming Xu, Wanmei Li, Xiaoling Li, Pengfei Zhang, Jinsong Wang, Kejie Chai
  • Publication number: 20190383996
    Abstract: A liquid crystal display and a backlight module thereof are provided. The backlight module includes a backlight source and a light guide plate. The backlight source is disposed at a side surface of the light guide plate. The light guide plate has an accommodation section for accommodating a functional module. The backlight module includes a compensation light source that is disposed on the light guide plate. The accommodation section is located between the backlight source and the compensation light source. The backlight module includes a compensation light source, and the backlight source and the compensation light source are located at two opposite sides of the accommodation section. The compensation light source may compensate for the illumination light in the light guide plate blocked by the functional module, so as to solve the non-uniform display problem of blocking the illumination light from the backlight source by the functional module.
    Type: Application
    Filed: January 19, 2018
    Publication date: December 19, 2019
    Inventor: Xiaoling LI
  • Patent number: 10500568
    Abstract: The present invention discloses a core-shell structure supported tungsten composite catalyst and a preparation method and use thereof. Most of the existing synthesis methods of the main ring of quinolone drugs have the defects of many synthesis steps, cumbersome operation, large amount of three wastes, higher costs and the like. The present invention prepares a magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, by preparing Fe3O4 colloid and SiO2/Fe3O4 composite nano-particles. This magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, is used to catalyze and synthesize quinolone compounds. The present invention provides an efficient preparation method of quinolone compounds using a catalyst which can be recovered by magnetic separation and recycled.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 10, 2019
    Assignees: Hangzhou Normal University, Zhejiang Benli Technology Co., Ltd.
    Inventors: Pengfei Zhang, Chao Shen, Xiaoling Li, Jun Xu, Haining Gu
  • Publication number: 20190372054
    Abstract: The present application relates to a display screen, a display device and a method for manufacturing a display screen. The display screen comprises a contour line and an active display region. The active display region includes an edge display region close to the contour line and a main display region away from the contour line. The edge display region and the contour line are intersected. The display screen includes a light-emitting layer and a light-outputting layer having a first region, the first region of the light-outputting layer has a scattering structure provided thereon. Light emitted from the light-emitting layer is deviated from an original propagation direction after passing through the scattering structure. The first region is formed into at least a partial region on the light-outputting layer corresponding to the edge display region.
    Type: Application
    Filed: August 15, 2019
    Publication date: December 5, 2019
    Inventors: Xiaoling LI, Xiaoxu HU, Panpan WANG
  • Publication number: 20190321299
    Abstract: The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
    Type: Application
    Filed: May 2, 2019
    Publication date: October 24, 2019
    Inventor: Xiaoling LI
  • Patent number: 10389710
    Abstract: Extracting characteristic information includes receiving a collection command from a client, obtaining, via a collection device, biometric information based on the collection command, selecting a stored extraction algorithm corresponding to the client, the stored extraction algorithm being selected from among a plurality of stored extraction algorithms, extracting characteristic values from the obtained biometric information, the characteristic values being extracted based on the selected extraction algorithm, and sending the extracted characteristic values to the client.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: August 20, 2019
    Assignee: Alibaba Group Holding Limited
    Inventors: Xiaoling Li, Junkui Li, Jupeng Xia, Yan Hu