Patents by Inventor Xiaoling Liang

Xiaoling Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOTORESPONSIVE PEPTIDE DELIVERY SYSTEM AND METHOD OF USING THE SAME
    Publication number: 20250177423
    Abstract: Provided herein is a photoresponsive prodrug comprising an active agent conjugated to a photoresponsive group, and a nanoparticle, wherein the photoresponsive prodrug is co-assembled with a polymer to form a nanoparticle. Also provided is a method of treating a subject, comprising administering photoresponsive prodrug or the nanoparticle to the subject, and irradiating at the target site with a light source.
    Type: Application
    Filed: December 3, 2024
    Publication date: June 5, 2025
    Applicants: THE UNIVERSITY OF HONG KONG, Zhongshan Ophthalmic Center, Sun Yat-sen University
    Inventors: Weiping WANG, Xiaoling LIANG, Yang ZHOU, Jia LI
  • Methods and compositions for preventing or treating ophthalmic conditions
    Patent number: 11944662
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Grant
    Filed: August 11, 2023
    Date of Patent: April 2, 2024
    Assignee: STEALTH BIOTHERAPEUTICS INC.
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20230381264
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: August 11, 2023
    Publication date: November 30, 2023
    Applicant: Stealth BioTherapeutics Inc.
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20230346874
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: February 9, 2023
    Publication date: November 2, 2023
    Applicant: Stealth BioTherapeutics Inc.
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • Methods and compositions for preventing or treating ophthalmic conditions
    Patent number: 11612633
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: March 28, 2023
    Assignee: STEALTH BIOTHERAPEUTICS INC.
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • Methods of cancer treatment using tumor antigen-specific T cells
    Patent number: 11471519
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: October 18, 2022
    Assignees: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun Zhou, Yanyan Han, Xihe Chen, Xiaoling Liang
  • Methods of obtaining tumor-specific T cell receptors
    Patent number: 11390659
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: July 19, 2022
    Assignees: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun Zhou, Yanyan Han, Xiaoling Liang, Xihe Chen
  • METHODS OF CANCER TREATMENT USING TUMOR ANTIGEN-SPECIFIC T CELLS
    Publication number: 20220125904
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 28, 2022
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN, Xiaoling LIANG
  • Methods of cancer treatment using tumor antigen-specific T cells
    Patent number: 11219676
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 11, 2022
    Assignees: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun Zhou, Yanyan Han, Xihe Chen, Xiaoling Liang
  • METHODS OF OBTAINING TUMOR-SPECIFIC T CELL RECEPTORS
    Publication number: 20210198341
    Abstract: Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.
    Type: Application
    Filed: April 12, 2019
    Publication date: July 1, 2021
    Applicants: SYZ Cell Therapy Co., HRYZ (Shenzhen) Biotech Co.
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xiaoling LIANG, Xihe CHEN
  • METHODS OF CANCER TREATMENT USING TUMOR ANTIGEN-SPECIFIC T CELLS
    Publication number: 20210154285
    Abstract: The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 27, 2021
    Inventors: Xiangjun ZHOU, Yanyan HAN, Xihe CHEN, Xiaoling LIANG
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20210154259
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: July 2, 2020
    Publication date: May 27, 2021
    Applicant: Stealth BioTherapeutics Corp
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20200061147
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: January 25, 2019
    Publication date: February 27, 2020
    Inventors: Liping LIU, Shibo TANG, Xiaoling LIANG
  • Methods and compositions for preventing or treating ophthalmic conditions
    Patent number: 10188692
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: January 29, 2019
    Assignee: Stealth Biotherapeutics Corp
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20170326197
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: January 9, 2017
    Publication date: November 16, 2017
    Inventors: Liping LIU, Shibo TANG, Xiaoling LIANG
  • Methods and compositions for preventing or treating ophthalmic conditions
    Patent number: 9549963
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 24, 2017
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20160058825
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pi gmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: March 27, 2015
    Publication date: March 3, 2016
    Inventors: Liping LIU, Shibo TANG, Xiaoling LIANG
  • Methods and compositions for preventing or treating ophthalmic conditions
    Patent number: 9023807
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: May 5, 2015
    Assignee: Stealth Peptides International, Inc.
    Inventors: Liping Liu, Shibo Tang, Xiaoling Liang
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS
    Publication number: 20140044689
    Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: May 17, 2013
    Publication date: February 13, 2014
    Inventors: Liping LIU, Shibo TANG, Xiaoling LIANG
  • Hole puncher
    Patent number: D1046963
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: October 15, 2024
    Inventor: Xiaoling Liang