Patents by Inventor Xiaoling Song

Xiaoling Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250091641
    Abstract: Provided herein is a system and method for monitoring the health of a steering system of a vehicle. Methods can include: receiving location information and motion information associated with a vehicle; determining, from the location information, a map-matched road segment associated with the location information; establishing a geometry of the map-matched road segment based on map data of a map database; filtering the motion information associated with the vehicle to establish a baseline movement of the vehicle; determining, during the baseline movement of the vehicle, steering angle input received at a steering system of the vehicle; determining, from the steering angle input received at the steering system of the vehicle, a steering angle offset; and causing the steering angle offset to be applied to the steering system of the vehicle.
    Type: Application
    Filed: September 13, 2024
    Publication date: March 20, 2025
    Inventors: Zongzheng LI, Jinghui SONG, Haimo BI, Xiaoling HAN, Michael Scott DONALDSON
  • Patent number: 12247085
    Abstract: A hybridoma cell line of secreting cyproheptadine monoclonal antibodies with a preservation number of CGMCC No. 14699 belongs to the field of food safety immunological detection. BALB/c mice are immunized through one time immunization with complete freund's adjuvant, three times of booster immunization with incomplete freund's adjuvant and one time of rush immunization with cyproheptadine complete antigen without adjuvant; the spleen cells from BALB/C mice immunized with high potency and low value of IC50 are fused with murine myeloma cells; and then the hybridoma cell line is obtained through indirect competitive ELISA screening and three sub-clones. The monoclonal antibody secreted by this cell line has good specificity and detection sensitivity to cyproheptadine (value of IC50 is 0.37 ng/ml), being suitable for detection of cyproheptadine in food.
    Type: Grant
    Filed: December 27, 2022
    Date of Patent: March 11, 2025
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Chuanlai Xu, Hua Kuang, Wei Jiang, Liguang Xu, Wei Ma, Liqiang Liu, Xiaoling Wu, Shanshan Song, Yongming Hu
  • Publication number: 20250064837
    Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.
    Type: Application
    Filed: October 22, 2024
    Publication date: February 27, 2025
    Applicant: ShanghaiTech University
    Inventors: Xiaobao Yang, Biao Jiang, Renhong Sun, Chaowei Ren, Ning Sun, Ying Kong, Yan Li, Jinju Chen, Qianqian Yin, Xiaoling Song, Quanju Zhao, Xing Qiu
  • Patent number: 12226424
    Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 18, 2025
    Assignee: ShanghaiTech University
    Inventors: Xiaobao Yang, Biao Jiang, Renhong Sun, Chaowei Ren, Ning Sun, Ying Kong, Yan Li, Jinju Chen, Qianqian Yin, Xiaoling Song, Quanju Zhao, Xing Qiu
  • Patent number: 11771709
    Abstract: A compound of formula (I) and its antitumor application are disclosed. The compounds of formula (I) have degradation and inhibitory effects on ALK target proteins. They are mainly composed of four parts: the first part, ALK-TKI, being compounds with ALK tyrosine kinase inhibitory activity; the second part, LIN, being different kinds of linker (Linker); the third part, the ULM, being a small molecule ligand (ULM, ubiquitin ligase binding moiety) with ubiquitination of VHL, CRBN or other proteases; and the fourth part, the group A, being a carbonyl group or absent, which covalently bond ALK-TKI to LIN, wherein LIN and ULM are covalently bonded. A series of compounds designed and synthesized by the present disclosure have wide pharmacological activities, have functions of degrading ALK protein and inhibiting ALK activity, and can be used for related tumor treatment.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: October 3, 2023
    Assignee: ShanghaiTech University
    Inventors: Xiaobao Yang, Biao Jiang, Xiaoling Song, Haifan Lin, Ning Sun, Jinju Chen, Xing Qiu, Chaowei Ren, Ying Kong
  • Publication number: 20220313829
    Abstract: A bifunctional compound, or a pharmaceutically acceptable salt, an isomer, a prodrug, a polymorphic substance or a solvate thereof. The chemical structural formula of the bifunctional compound is represented as formula I, and the bifunctional compound can be used for preventing or treating cancers.
    Type: Application
    Filed: August 5, 2020
    Publication date: October 6, 2022
    Inventors: Xiaobao YANG, Biao JIANG, Xiaoling SONG, Ning SUN, Chaowei REN, Renhong SUN, Xiaojuan QU, Haixia LIU, Xing QIU
  • Publication number: 20220257776
    Abstract: A compound of general formula (I), a compound of general formula (III) and anti-tumor applications thereof. A series of compounds designed and synthesized have a wide range of pharmacological activities, have the function of degrading specific proteins and/or inhibiting activity, and can be used in related tumor and cancer treatments.
    Type: Application
    Filed: June 11, 2020
    Publication date: August 18, 2022
    Inventors: Xiaobao YANG, Biao JIANG, Xiaoling SONG, Ning SUN, Chaowei REN, Ying KONG, Jianshui ZHANG, Jinju CHEN, Yan LI, Yuedong ZHOU
  • Publication number: 20220154287
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 19, 2022
    Inventors: Catherine E. LOFTON-DAY, Andrew Z. SLEDZIEWSKI, Ralf LESCHE, Matthias SCHUSTER, Juergen DISTLER, Reimo TETZNER, Thomas HILDMANN, Fabian MODEL, Xiaoling SONG
  • Publication number: 20220117982
    Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.
    Type: Application
    Filed: April 9, 2019
    Publication date: April 21, 2022
    Applicant: ShanghaiTech University
    Inventors: Xiaobao Yang, Biao Jiang, Renhong Sun, Chaowei Ren, Ning Sun, Ying Kong, Yan Li, Jinju Chen, Qianqian Yin, Xiaoling Song, Quanju Zhao, Xing Qiu
  • Patent number: 11186879
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: November 30, 2021
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 11061028
    Abstract: This disclosure provides antigen compositions useful for diagnosing Lyme disease and for detecting antibodies that bind to Borrelia antigens. The antigenic compositions comprise a mixture of hybrid peptides and Borrelia proteins. This disclosure also provides devices, methods, and kits that are useful for diagnosing Lyme disease and for detecting anti-Borrelia antibodies in a sample to aid in the diagnosis of Lyme disease.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: July 13, 2021
    Assignee: Defined Diagnostics, LLC
    Inventors: Nina Lukinova, Xiaoling Song, Paul Francis Macomber, Jill Ann White
  • Publication number: 20200306273
    Abstract: A compound of formula (I) and its antitumor application are disclosed. The compounds of formula (I) have degradation and inhibitory effects on ALK target proteins. They are mainly composed of four parts: the first part, ALK-TKI, being compounds with ALK tyrosine kinase inhibitory activity; the second part, LIN, being different kinds of linker (Linker); the third part, the ULM, being a small molecule ligand (ULM, ubiquitin ligase binding moiety) with ubiquitination of VHL, CRBN or other proteases; and the fourth part, the group A, being a carbonyl group or absent, which covalently bond ALK-TKI to LIN, wherein LIN and ULM are covalently bonded. A series of compounds designed and synthesized by the present disclosure have wide pharmacological activities, have functions of degrading ALK protein and inhibiting ALK activity, and can be used for related tumor treatment.
    Type: Application
    Filed: June 15, 2020
    Publication date: October 1, 2020
    Applicant: ShanghaiTech University
    Inventors: Xiaobao Yang, Biao Jiang, Xiaoling Song, Haifan Lin, Ning Sun, Jinju Chen, Xing Qiu, Chaowei Ren, Ying Kong
  • Publication number: 20190316210
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 10385402
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 20, 2019
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Publication number: 20180149648
    Abstract: This disclosure provides antigen compositions useful for diagnosing Lyme disease and for detecting antibodies that bind to Borrelia antigens. The antigenic compositions comprise a mixture of hybrid peptides and Borrelia proteins. This disclosure also provides devices, methods, and kits that are useful for diagnosing Lyme disease and for detecting anti-Borrelia antibodies in a sample to aid in the diagnosis of Lyme disease.
    Type: Application
    Filed: September 23, 2015
    Publication date: May 31, 2018
    Inventors: Nina LUKINOVA, Xiaoling SONG, Paul Francis MACOMBER, Jill Ann WHITE
  • Patent number: 9926573
    Abstract: Disclosed is a glyphosate-tolerant gene. The nucleotide sequence of the gene is SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5, and a mutant form of the gene that maintains the glyphosate-tolerant activity. The amino acid sequence of a protein encoded by the gene is respectively SEQ ID NO: 2, SEQ ID NO: 4, or SEQ ID NO: 6, and a mutant form of amino acids in a conserved region 1 of positions 280 to 294 and in a conserved region 2 of positions 416 to 433. Also disclosed is the use of the gene and the mutant form thereof in the production of a glyphosate-resistant/tolerant plant.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: March 27, 2018
    Assignee: NANJING AGRICULTURAL UNIVERSITY
    Inventors: Sheng Qiang, Chanjuan Mao, Shiguo Chen, Weimin Dai, Xiaoling Song
  • Patent number: 9695478
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: July 4, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Publication number: 20160340689
    Abstract: Disclosed is a glyphosate-tolerant gene. The nucleotide sequence of the gene is SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5, and a mutant form of the gene that maintains the glyphosate-tolerant activity. The amino acid sequence of a protein encoded by the gene is respectively SEQ ID NO: 2, SEQ ID NO: 4, or SEQ ID NO: 6, and a mutant form of amino acids in a conserved region 1 of positions 280 to 294 and in a conserved region 2 of positions 416 to 433. Also disclosed is the use of the gene and the mutant form thereof in the production of a glyphosate-resistant/tolerant plant.
    Type: Application
    Filed: September 5, 2013
    Publication date: November 24, 2016
    Applicant: NANJING AGRICULTURAL UNIVERSITY
    Inventors: Sheng QIANG, Chanjuan MAO, Shiguo CHEN, Weimin DAI, Xiaoling SONG
  • Publication number: 20160312287
    Abstract: Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
    Type: Application
    Filed: December 23, 2015
    Publication date: October 27, 2016
    Inventors: Susan Cottrell, Fabian Model, Carolina Haefliger, Gunter Weiss, Juergen Distler, Andrew Z. Sledziewski, Xiaoling Song, Thomas L. Skillman, Jeffrey G. Thomas
  • Publication number: 20160304964
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: March 23, 2016
    Publication date: October 20, 2016
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song